Cysteine complexes of palladium(II) and platinum(II)

Within the framework of our research activities related to the partitioning of spent nuclear-fuel solutions, the direct selective extraction of trivalent actinides from a simulated PUREX raffinate was studied using a mixture of CyMe 4 BTBP and TODGA (1-cycle SANEX). The solvent showed a high selectivity for trivalent actinides with a high lanthanide separation factor. However, the coextraction of some fission product elements (Cu, Ni, Zr, Mo, Pd, Ag, and Cd) from a simulated PUREX raffinate was observed, with distribution ratios up to 30 (Cu). The extraction of Zr and Mo could be suppressed using oxalic acid but the use of the well-known Pd complexant N-(2-Hydroxyethyl)-ethylendiamin-N,N ,N -triacetic acid (HEDTA) was unsuccessful. During screening experiments with different amino acids and derivatives, the sulfur-bearing amino acid L-Cysteine showed good complexation of Pd and prevented its extraction into the organic phase without influencing the extraction of the trivalent actinides Am (III) and Cm (III). The optimization studies included the influence of the L-Cysteine and HNO 3 concentration and the kinetics of the extraction. The development of a process-like extraction series showed very promising results in view of further optimizing the process. A strategy for a single-cycle process is proposed within this article.

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“…[32] The compounds showed a square planar complexation of palladium through the sulfur atoms and carboxy groups of two L-Cysteine molecules.…”

Section: Experiments With Simulated Har Solutionmentioning

confidence: 99%

Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe₄BTBP and TODGA as 1-cycle SANEX Solvent

Wilden

Schreinemachers

Sypuła

et al. 2011

Solvent Extraction and Ion Exchange

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“…respectively [17], [18]. The bands are due to coordinate chloride ion in complexes formed with metal chloride were fall bellow the limits of our infrared spectrophotometer and could not be observed.…”

Section: Infrared Spectramentioning

confidence: 57%

Synthesis and characterization of novel metal complexes of (pentulose-?-lactone-2,3-enedibenzoate barbituric acid) with some metal ions

Journal¹

2013

Baghdad Sci.J

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New (pentulose-?-lactone-2,3-enedibenzoate barbituric acid) (L) have been synthesized by reaction of (5-C-dimethyl malonyl-pentulose-?-lactone-2,3-enedibenzoate) with urea in alkaline media (sodium methoxide). (Ca+2, Co+2, Ni+2, Cu+2, Zn+2, Cd+2 and Hg+2) complexes of (pentulose-?-lactone-2,3-enedibenzoate barbituric acid) (L) have been prepared and characterized by (1H and 13CNMR), FTIR, (U.V-Vis) spectroscopy, Atomic absorption spectrophotometer (A.A.S), Molar conductivity measurements and Magnetic moment measurements, and the following general formula has been given for the prepared complexes [MLCl2(H2O)].XH2O, where M = (Ca+2, Co+2, Ni+2, Cu+2, Zn+2, Cd+2, Hg+2), X = five molecules with (Cd+2) complex, L = (pentulose-?-lactone-2,3-enedibenzoate barbituric acid).

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“…The ν as (COO − ) and ν s (COO − ) bands in the spectrum of C3 appear at 1731 and 1544 cm −1 respectively (see supporting information, Figure S3). The terminal coordination by the carboxylate group of L‐cys has been confirmed by a positive shift of ν as (COO − ) and a negative shift of ν s (COO − ) as compared to the free ligand. A strong absorption band at 1715 cm −1 in the IR spectrum of N‐ac‐L‐cys, assigned to its carboxylic group is found to be shifted to 1654 cm −1 in C4 and provides a strong evidence for carboxylate coordination to Pd(II) in this complex (see supporting information, Figure S4).…”

Section: Resultsmentioning

confidence: 83%

In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study

et al. 2018

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In the aspect of an effective palladium based anticancer drug design, Pd(II) complexes [Pd(MAMP)Cl2], C1; [Pd(MAMP)(H2O)2]x2, C2; [Pd(MAMP)(L‐cys)]x, C3; [Pd(MAMP)(N‐ac‐L‐cys)], C4; [Pd(MAMP)(DL‐meth)]x2, C5; and [Pd(MAMP)(DL‐pen)]x, C6 (where x=ClO4−/NO3−) have been synthesised and characterised where 2‐[(methylamino)methyl]pyridine (MAMP) has been considered as carrier ligand and chloride, aqua, L‐cysteine (L‐cys), N‐acetyl‐L‐cysteine (N‐ac‐L‐cys), DL‐methionine (DL‐meth) and DL‐penicillamine (DL‐pen) are selected as leaving group. DNA as well as protein binding ability of the complexes has been investigated with CT‐DNA and BSA and the related binding parameters have been evaluated. Kinetic investigation for the reactions of Pd(II)‐diaqua complex C2 with four selected sulfur containing bio‐molecules have been carried out under pseudo first order condition. In addition, theoretical investigation has also been considered for structural optimisation, frontier molecular orbital mapping, TD‐DFT and NBO analysis. To get an insight into the cytotoxicity, the complexes have been treated on three different cancer cell lines (A549, HeLa, Hep G2) which reveal comparable anticancer activity of the reported complexes with the clinically acquainted anticancer drug Cisplatin. Very less complex initiated reactive oxygen species (ROS) with low degree of cell death in two different non‐tumour cell lines (L6 myotubes and HEK 293) indicate minimum normal cell toxicity of the complexes.

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Cysteine complexes of palladium(II) and platinum(II)

Cited by 58 publications

References 10 publications

Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe₄BTBP and TODGA as 1-cycle SANEX Solvent

Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe₄BTBP and TODGA as 1-cycle SANEX Solvent

Synthesis and characterization of novel metal complexes of (pentulose-?-lactone-2,3-enedibenzoate barbituric acid) with some metal ions

In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study

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Cysteine complexes of palladium(II) and platinum(II)

Cited by 58 publications

References 10 publications

Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe4BTBP and TODGA as 1-cycle SANEX Solvent

Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe4BTBP and TODGA as 1-cycle SANEX Solvent

Synthesis and characterization of novel metal complexes of (pentulose-?-lactone-2,3-enedibenzoate barbituric acid) with some metal ions

In Vitro DNA/BSA Binding, Anticancer and Normal Cell Activity of Pd(II) Complexes: Substitution Behaviour and Computational Study

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Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe₄BTBP and TODGA as 1-cycle SANEX Solvent

Direct Selective Extraction of Actinides (III) from PUREX Raffinate using a Mixture of CyMe₄BTBP and TODGA as 1-cycle SANEX Solvent