Cysteine-cysteine chemokine receptor 5 (CCR5) profile of HIV-infected subjects attending University of Calabar Teaching Hospital, Calabar, Southern Nigeria

Ekere, Ekerette Friday; Useh, MF; Okoroiwu, Henshaw Uchechi; Mirabeau, Tatfeng Youtchou

doi:10.1186/s12879-019-4737-1

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…This result also is in agreement with the results of Ekere et al, in which they got (100%) homozygous CCR5 - WT from all their participant in a research conducted at the University of Calabar, Teaching Hospital in Nigeria and there was also no CCR5-Δ32 allele detected in the population. 17 This shows that there is low/ absence of CCR5-Δ32 mutation in the Nigerian and Zimbabwean populations. Higher frequency of CCR5-Δ32 mutation has been reported in Northern Europe and a gradual decline south and eastward is observed, with no or rare occurrence in Africa, Asia, Americas and Oceania.…”

Section: Discussionmentioning

confidence: 91%

CCR5-Δ32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

Ndikom¹,

Ergören²,

Sayan³

et al. 2022

Afr H. Sci.

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Background: The cystine-cystine chemokine receptor 5 (CCR5) is the primary HIV co-receptor involved in the viral entry process into human cells. The 32 bp deletion variant within the CCR5 gene (CCR5-Δ32) plays a very important role in viral recognition and progression of AIDS. Objective: The current study was aimed at evaluating the CCR5-Δ32 gene variation frequency in Nigerian and Zimbabwean populations residing in Northern Cyprus. Methods: A total number of 211 subjects (103 Nigerians and 108 Zimbabweans) were analyzed. Nigerian population was further analyzed with respect to the three major ethnicities: Igbo, Hausa, and Yoruba. Polymerase Chain Reaction was used to determine the CCR5-Δ32 gene variant status. Results: All studied subjects from both sampling groups were homozygous for the CCR5 wild type gene (CCR5–wt), meaning neither heterozygous nor homozygous genotypes of CCR5-Δ32 gene variant were observed.Conclusion: This study observed the absence of CCR5-Δ32 deletion gene in the Nigeria and Zimbabwean populations living in Northern Cyprus. These populations lack the genetic advantage over HIV infection and may also show a rapid progression towards AIDS. Additionally, these populations could impact the local gene frequency as these two populations interact more and more. Keywords: CCR5-Δ32; HIV; Nigerian; Zimbabwean; CCR5; North Cyprus.

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Section: Discussionmentioning

confidence: 91%

CCR5-Δ32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

Ndikom¹,

Ergören²,

Sayan³

et al. 2022

Afr H. Sci.

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“…The hospital has 410 bed space capacity with 15 wards and 11 clinics. 16 , 17 Though there is no published data on annual deliveries in the center, there is more than 2000 deliveries annually in the center. 18 …”

Section: Methodsmentioning

confidence: 99%

Causes of infant and under-five (under-5) morbidity and mortality among hospitalized patients in Southern Nigeria: A hospital based study

Okoroiwu,

Edet,

Uchendu

et al. 2024

Journal of Public Health Research

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Background: Rate and pattern of under-five mortality is a reflection of a society’s healthcare system and quality of life. This study is aimed at reviewing the causes of infants and under-five morbidity and mortality in Calabar, Southern Nigeria. Methods: This study used retrospective descriptive cross-sectional design. We did a retrospective collation of data on under-five morbidity and mortality from 2012 to 2017 of under-five patients admitted or died while in admission in University of Calabar Teaching Hospital. The causes of morbidity and mortality were reported based on International Classification of Diseases 10 (ICD-10). The morbidity, mortality and fatality rates were computed. Results: A total of 11,416 under-five admissions and 391 deaths were recorded within the study period giving a fatality rate of 3.4%. Age 1–4 years category represented 50.5% of the admissions while infants (<1 year) constitute majority of the deaths (64.7%). There were 5652 infant admissions and 253 infant deaths giving fatality rate of 4.5% within the study period. Males constituted majority (55.8%) of under-five morbidity whereas females constituted majority (51.2%) of the deaths. Conditions originating from perinatal period; and infectious and parasitic diseases were the leading broad cause of under-five mortality. Specific disease analysis showed sepsis/septicemia; congenital infectious and parasitic diseases; slow fetal growth, malnutrition and short gestation as the chief causes of both infant and under-five mortality. Conclusion: The leading causes of under-five deaths in the studied population are amenable. Improved healthcare and antenatal will be of immense benefit.

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“…It is located in the Calabar metropolis (which is fusion of Calabar South Local Government and Calabar Municipal local Government) ( Fig. 1 ) [9] . The hospital has a 410-bed space capacity with 15 wards and 11 clinics [10] .…”

Section: Methodsmentioning

confidence: 99%

Assessment of blood supply and usage pre- and during COVID-19 pandemic: A lesson from non-voluntary donation

Ogar

Okoroiwu

Obeagu

et al. 2021

Transfusion Clinique et Biologique

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Background Ensuring steady stream of safe blood is the ultimate goal of blood transfusion practice. The current COVID-19 pandemic has affected almost every part of life and economy. Consequently, this study sets off to assess the effect of the pandemic on blood supply and blood transfusion in the University of Calabar Teaching Hospital. Methods Data from the Donor Clinic and Blood Group Serology Unit of the University of Calabar Teaching Hospital were retrospectively extracted to evaluate supply and use of blood before and during COVID-19 pandemic. Result A total of 1638 donors were recorded within the study period. Age range 15–29 and 30–44 years constituted majority of the subjects (58.9% and 33.4%, respectively). The donor pool were male-dominated. Commercial donors (61.7%) and family replacement donors (30.6%) constituted majority of the donor pool. Most of the donor pool were students (37.1%), public servants (22.8%) and artisans (18.6%). A concomitant decrease of 26.1% and 18.9% were recorded in blood donation and request during the COVID-19 pandemic. Conclusion Blood supply was not significantly affected in our study center as both requests and donations decreased. Consideration for improving family replacement donation was advised.

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Cysteine-cysteine chemokine receptor 5 (CCR5) profile of HIV-infected subjects attending University of Calabar Teaching Hospital, Calabar, Southern Nigeria

Cited by 13 publications

References 28 publications

CCR5-Δ32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

CCR5-Δ32 gene variant frequency in the Nigerian and Zimbabwean populations living in North Cyprus

Causes of infant and under-five (under-5) morbidity and mortality among hospitalized patients in Southern Nigeria: A hospital based study

Assessment of blood supply and usage pre- and during COVID-19 pandemic: A lesson from non-voluntary donation

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