2005
DOI: 10.1111/j.1440-1681.2005.04300.x
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Cysteinyl leukotrienes and leukotriene B4 mediate vasoconstriction to arginine vasopressin in rat basilar artery

Abstract: Arginine vasopressin (AVP) has been reported to be involved in the development of cerebral vasospasm after haemorrhage and cerebral oedema following ischaemia. Endogenously produced 5-lipoxygenase metabolites are able to contract isolated endothelium-preserved arterial strips and modulate vascular permeability. The present study addresses the role of 5-lipoxygenase and its products, namely cysteinyl leukotrienes (CysLTs) and leukotriene (LT) B4, in the contraction induced by AVP in rat basilar artery. Contract… Show more

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Cited by 7 publications
(5 citation statements)
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“…Priming of PMNs by LTB 4 and it metabolites occurred through activation of the dominant, chemotactic, high affinity BLT1 receptor as shown by the use of the BLT1 receptor antagonist CP-105,696 (21,10) (22,23), which significantly inhibited their PMN priming activity. These data confirmed that the BLT1 receptor is not specific for LTB 4 alone but demonstrated that receptor activation induced priming of the PMN oxidase (14).…”
Section: Discussionmentioning
confidence: 99%
“…Priming of PMNs by LTB 4 and it metabolites occurred through activation of the dominant, chemotactic, high affinity BLT1 receptor as shown by the use of the BLT1 receptor antagonist CP-105,696 (21,10) (22,23), which significantly inhibited their PMN priming activity. These data confirmed that the BLT1 receptor is not specific for LTB 4 alone but demonstrated that receptor activation induced priming of the PMN oxidase (14).…”
Section: Discussionmentioning
confidence: 99%
“…The LTB 4 -induced contractions of the latter preparation reveal LTB 4 as being rather vasoactive than a bronchoconstrictor [59]. In fact, with a noncumulative approach, LTB 4induced vasoconstriction has been detected in the human pulmonary artery [59], guinea-pig pulmonary artery and aorta [36,59], as well as in rat basilar artery [69]. This LTB 4 -induced vasoconstriction is an indirect response mediated by the release of histamine and thromboxane (TX) A 2 [36,59].…”
Section: Vasoconstrictionmentioning
confidence: 95%
“…The LTB 4 -induced vasoconstriction, demonstrated in human pulmonary artery , in guinea pig pulmonary artery and aorta Sakata et al, 2004), and in rat basilar artery (Trandafir et al, 2005), has led to the hypothesis that nonmyeloid cells, such as SMCs, also express BLT receptors. Immunohistochemical analysis of human arteries has revealed BLT 1 R expression in the muscular layers of carotid atherosclerotic endarterectomies, as well as in human nonatheroclerotic mammary arteries (Bä ck et al, 2005).…”
Section: Vascular Smooth Muscle Cellsmentioning
confidence: 99%