Cystic and pseudocystic pulmonary malformations in children: Clinico-pathological correlation

Congenital cystic diseases of the lung

“…These are complex structures that can undergo changes during embryonic development and lead to pulmonary malformations. 3 These diseases often share common etiological mechanisms and histopathological features, thought to arise from disrupted interaction between embryological mesodermal and ectodermal lung components during development. 1,2 The terminology and classification of cystic lung malformations have long been debated.…”

“…8 Furthermore, these lesions have been reported to be responsible for fetal demise, severe respiratory distress in the neonatal period, and recurrent lung infections, and may even serve as precursors to malignant lesions. 3 However, the risk of malignancy in this population has not been fully defined. 8 There is consensus on the necessity of surgical resection in symptomatic lesions; however, opinions are divided between surgical and more conservative approaches in clinically silent cases.…”

Quantitative CT imaging analysis to predict pathology features in patients with a congenital pulmonary airway malformation

“…The use of CT to predict histopathological outcome is increasingly being reported in other diseases and utilizing objective, quantitative scoring methods increase the reliability [ 27 , 28 ]. Previous research on the CT-pathology correlation in CPAM, has primarily focused on the diagnosis of the CPAM subtype [29][30][31][32][33][34][35] . In our current study we aimed to investigate if CT-imaging characteristics can be used to predict histopathological features, by using an objective quantitative CT scoring method.…”