Cystic disease of the lung with emphasis on emphysematous blebs and bullae

Head, Jerome R.

doi:10.1016/0002-9610(55)90575-4

Cited by 12 publications

(3 citation statements)

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“…Of al! those who have written on pulmonary air cysts only Head (1951Head ( , 1955 has expressed similar views and reached similar conclusions. He described two cases in which one lobe was grossly emphysematous, compressing the adjacent lung.…”

Section: Discussionmentioning

confidence: 55%

“…He compared these cases with acute obstructive emphysema in infants, in which a definite bronchial .. ballvalve" can be conclusively demonstrated to be the cause of the condition; in these patients the lobe inflates only to the volum~ it occupies in maximal inspiration (and therefore can only be visualized radiologically in expiration). In the more recent article (Head, 1955) the author extends the concept of trapped col!aterally supplied air, admittedly with little further evidence, to account for ail forms of emphysema.…”

Section: Discussionmentioning

confidence: 99%

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The Histology of Localized Emphysema

1957

Australasian Annals of Medicine

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SUMMARY The histological features of several types of lesions showing localized emphysema are presented. Most such lesions were associated macroscopically with either bronchiectasis (or bronchiolectasis) or “ scarring ” in the affected area ; examples of each type are described. In several of these localized lesions it was possible to demonstrate unequivocally that the emphysematous region was wholly aerated by collateral ventilation and that the original bronchiole that supplied the area was obliterated. These observations provide conclusive morphological evidence to support the hypothesis of pathogenesis of emphysema which was presented to account for the histological changes observed in the generalized condition, in which the evidence for the hypothesis was, to a large extent, deductive. The close relation between the localized and the generalized disease is emphasized by the observation that bronchiolar inflammatory damage and obliteration is similar in pattern and the initial lesion is centrolobular (or “ focal ”) in both. The features of any emphysematous lesion, either localized or generalized, are shown to be determined largely by the nature of the causative inflammatory process, the emphysema itself being due to a single process—“ trapping ” of collaterally ventilated air. This study of localized lesions also emphasizes the intimate association of the three manifestations of permanent inflammatory damage to the lung—emphysema, bronchiectasis and “ scarring ” ; it also indicates that these three are properly regarded as sequelæ of inflammatory obstruction and obliteration of bronchioles. Man is in truth ever the same ; even when the direct succession of cause and effect does not come in, we see that in times and places most remote from one another like events follow upon like causes. E. A. FREEMAN : “ Comparative Politics ”.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

The Histology of Localized Emphysema

1957

Australasian Annals of Medicine

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“…Infected giant air cysts also have a similar radiographie and gross macroscopic appearance with congenital bronchial cysts . However, the bu llous cysts are assoeiated with several o ther small ones (blebs) of a similar nature in the lobe concerned, and evidences of emphysematous chan ges and of the underlying et iology abo und in those pa rts of the lung most prone to such cnanges, particularly at th e apex where they are assoeiated with the so-called apical scars, aud in the unsupported margins of the lung (I , 13,15). When cut open , air cysts are seen to be tr aversed by several interlobular septa and vessels, being the remains of destroyed alveoli, and thelr walls comprise mainly compressed alveolar tissue with no lining bronc hial epithelium.…”

Section: Differential Diagnosismentioning

confidence: 99%

Intraparenchymal Bronchogenic Cysts in Adults

Ro¹

1982

Thorac cardiovasc Surg

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Bronchogenic cysts are uncommonly diagnosed in adults. Herein presented are 4 such cysts of the intaparenchymal variety which occurred in 3 adult Nigerians. The salient features illustrating the nuances and variations of their presentation in accordance with their location within the lungs are discussed in the context of the congenital origin of the cysts. The etiology is reviewed and the difficulties in diagnosis are discussed as well as the acceptability of the bronchogenic cyst as a differential diagnosis of common cystic pulmonary pathologies, especially if solitary, in adults.

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Macrobullous Medullary Polycystic Kidney and Cystic Lung Disease

1971

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A 20-month-old girl died in renal failure with macrobullous medullary polycystic disease of the kidney and bilateral congenital cystic disease of the lungs. Respiratory difficulty and a shifted mediastinum necessitated two pulmonary resections in infancy. The surgically resected cysts were clearly malformations consistent with cystic adenomatoid malformation and were entirely different from the cysts present at necropsy which resembled dilated normal bronchioles. The macrobullous renal cysts were confined to the medulla; however, the clinical course and the morphologic appearance of the cystic kidney were typical of neither medullary sponge kidney or medullary cystic disease. Recent evidence suggests that the differences between medullary sponge kidney, medullary cystic disease, and polycystic kidney, in some instances, may be a result of clinical selection. We concluded that the association of macrobullous medullary polycystic kidney disease and pulmonary cysts in this patient was fortuitous.

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Cystic disease of the lung with emphasis on emphysematous blebs and bullae

Cited by 12 publications

References 0 publications

The Histology of Localized Emphysema

The Histology of Localized Emphysema

Intraparenchymal Bronchogenic Cysts in Adults

Macrobullous Medullary Polycystic Kidney and Cystic Lung Disease

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