Cystic Fibrosis

Stephan, U; Götz, M.; Stephan, KM; Bender, S. W.

doi:10.1007/978-3-642-67557-7_3

Cited by 3 publications

(2 citation statements)

References 521 publications

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“…This disorder, whose fundamental cause is unknown, is characterized by the presence of elevated sodium concentrations in secretions such as sweat (1,13). Chronic bronchopulmonary infections, frequently caused by mucoid strains of P. aeruginosa, occur commonly (10,12). We have outlined the elements of a pulmonary defense system, highly effective against mucoid P. aeruginosa and sensitive to small gradations of NaCl concentration, in rabbit lung components.…”

Section: Discussionmentioning

confidence: 99%

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

Lehrer¹,

Selsted²,

Szklarek³

et al. 1983

Infect Immun

117

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Microbicidal cationic proteins 1 and 2, peptides derived from rabbit lung macrophages, were tested for bactericidal activity against various bacterial species. Both were highly active against diverse gram-positive and gram-negative organisms under conditions of near-neutral pH (between 7 and 8) and relatively low ionic strength. Susceptible species included Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Listeria monocytogenes, Pseudomonas aeruginosa, Klebsiella pneumoniae, Haemophilus influenzae, Escherichia coli, and Serratia marcescens. Streptococcus agalactiae, type 1A, was less susceptible than the aforementioned organisms or S. agalactiae, type 3. Bordetella bronchiseptica, a common commensal and pathogen of the rabbit respiratory tract, was completely resistant to both peptides.

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Section: Discussionmentioning

confidence: 99%

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

Lehrer¹,

Selsted²,

Szklarek³

et al. 1983

Infect Immun

117

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“…Im Sekret ekkriner Schweißdrüsen gesunder Kinder schwanken die pH-Werte zwischen 4 und 6. Bei Kindern mit einer Mukoviszidose wurden jedoch im Schweiß einzelner Drüsen pH-Werte um den Neutrdlpunkt herum gemessen(8,12).…”

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Potentiometrische Messungen der Hautoberflächenazidität hautgesunder Kinder und von Kindern mit Mukoviszidose

1983

Klin Padiatr

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Actual acidity of the skin surface as well as the capacity to neutralize topically applied 0,01 n NaOH were measured by means of a potentiometric procedure. 50 children without diseases of their skin showed pH values between 4,5 and 6,1 (mean pH = 5,24) when tested at the volar forearms. A significant shift towards higher acidity became apparent by pH readings (4,1--5,7; mean 4,73) in 25 patients suffering from mucoviscidosis. In both groups no difference could be found in regeneration of the skin acidity after exposure to NaOH. Our results favour the assumption that elevated skin surface acidity in patients with mucoviscidosis is due to qualitative or quantitative differences in the biochemical composition of the epidermis.

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Mukoviszidose (zystische Fibrose)

Stephan¹,

Wiesemann²

1985

Pädiatrische Pneumologie

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Cystic Fibrosis

Cited by 3 publications

References 521 publications

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

Potentiometrische Messungen der Hautoberflächenazidität hautgesunder Kinder und von Kindern mit Mukoviszidose

Mukoviszidose (zystische Fibrose)

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