“…Not easier is the task of categorizing the even more heterogeneous oligo-and mono-symptomatic CFTR-RD. In this regard CFTR mutations have been linked to a wide series of pathologies: obstructive azoospermia for CBAVD (Claustres, 2005;Cuppens & Cassiman, 2004;Stuhrmann & Dork, 2000); non-obstructive azoospermia, reduced sperm quality and spermatogenesis defects (Boucher et al, 1999;Dohle et al, 2002;Jakubiczka et al, 1999;Jarvi et al, 1998;Mak et al, 2000;Pallares-Ruiz et al, 1999;van der Ven et al, 1996); male hypofertility due to idiopathic seminal hyperviscosity (Elia et al, 2009;Rossi et al, 2004); female hypofertility due to thick cervical mucus (Gervais et al, 1996;Hayslip et al, 1997); neonatal hypertrypsinaemia with normal sweat test (Castellani et al, 2001a;Gomez Lira et al, 2000;Narzi et al, 2007;Padoan et al, 2002); idiopathic pancreatitis (Castellani et al, 2001b;Gomez Lira et al, 2000;Maire et al, 2003;Pallares-Ruiz et al, 2000); pulmonary diseases (Bombieri et al, 1998;Bombieri et al, 2000); disseminated bronchiectasis (Girodon et al, 1997;Pignatti et al, 1995); chronic rhinosinusitis (Raman et al, 2002;Southern, 2007;Wang et al, 2000b); nasal polyposis (Kerem, 2006;Pawankar, 2003); metabolic alkalosis, hypochloremia, hyponatriemia, hypokalemia and dehydration (Augusto et al, 2008;Kerem, 2006;Leoni et al, 1995;…”