Cystic fibrosis and pregnancy

Goddard, Julie; Bourke, Stephen

doi:10.1576/toag.11.1.19.27464

Cited by 11 publications

(3 citation statements)

References 31 publications

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“…Prematurity is one of the most common complications in pregnant women with CF [5,6]. Until now, there have been no reports of higher rates of congenital malformations in babies born to mothers with CF compared to those born to healthy mothers [7], despite the possible teratogenic effect due to extensive drug therapy. Women with CF who became pregnant, frequently experience gestational diabetes, hemoptysis and reduced pulmonary function [8].…”

Section: Discussionmentioning

confidence: 99%

Case report of a successful pregnancy in a cystic fibrosis patient with the c.1521_1523delCTT/c.3718-2477C>t genotypes

Spasova

Koleva

Тончева

et al. 2020

Balkan Journal of Medical Genetics

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The aim of this case report was to show the consequences of pregnancy in a cystic fibrosis (CF) patient with a rare mutation. We present a case of a patient with CF, pregnant for the second time, who gave birth to a healthy child. Her mutation status revealed the presence of relatively rare mutation c.3718-2477C>T that is associated with a milder phenotype of the disease. During pregnancy, her vital signs were within normal limits. She had no exacerbations after the third gestational month. Cystic fibrosis is the most common genetic disorder among Caucasians. Over the last few decades, the survival rate and the lifespan of patients with CF have increased progressively. This is why more affected women are choosing to become pregnant. Predictive factors for the pregnancy outcome are basal pulmonary function [measured by forced expiratory volume/1 second (FEV1)], nutritional status [measured by body mass index (BMI)], diabetes and bacterial colonization. The report of our case emphasizes the need for establishing the exact mutations in CF patients who plan to become pregnant in order to predict the possible outcomes of this specific period of life. Moreover, genetic counseling is strongly recommended for the right understanding of the pregnancy risks in such cases.

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Section: Discussionmentioning

confidence: 99%

Case report of a successful pregnancy in a cystic fibrosis patient with the c.1521_1523delCTT/c.3718-2477C>t genotypes

Spasova

Koleva

Тончева

et al. 2020

Balkan Journal of Medical Genetics

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“…Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations of a gene on chromosome 7 which encodes for a chloride channel in the membranes of epithelial cells [1]. The reduced chloride conductance results in viscid secretions and organ damage in the respiratory and reproductive tracts and in the pancreatic and hepatobiliary ducts.…”

Section: Introductionmentioning

confidence: 99%

“…The development of CF-related diabetes mellitus (CFRDM) is also becoming more prevalent due to the improved survival of those living with CF [1]. CFRDM occurs in up to one half of all adults with CF [9] and has been associated with worse survival, especially in females [10].…”

Section: Introductionmentioning

confidence: 99%

Cystic Fibrosis-Related Diabetes Mellitus and Pregnancy: A Retrospective Study

et al. 2022

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Introduction: Cystic fibrosis-related diabetes mellitus (CFRDM) is becoming a more common issue in pregnancy care as the life expectancy of females living with cystic fibrosis has improved, with an increasing number of pregnancies in this population. Despite the Republic of Ireland having the highest incidence of cystic fibrosis globally, there is limited Irish data on pregnancy outcomes for those with CFRDM. This study aimed to retrospectively review maternal and foetal outcomes of pregnancies affected by maternal CFRDM. Methods: The patient records of all women with CFRDM who attended the National Maternity Hospital Dublin for obstetric care between 2015 and 2019 were retrospectively reviewed.Results: A search of patient records identified 15 pregnancies in 12 women with CFRDM during the study period. CFRDM was diagnosed pre-conception in ten of the 15 pregnancies. Median neonatal weight at birth was lower in women with CFRDM diagnosed pre-conception compared to women diagnosed during pregnancy (2.8 vs. 3.02 kg). The median weight gain in women with CFRDM diagnosed pre-conception was 10.9 kg compared to 11.9 kg for those diagnosed during pregnancy. The majority of women (62.5%) with CFRDM diagnosed preconception delivered via caesarean section. Admission for CF exacerbations during pregnancy in women with CFRDM diagnosed pre-conception was very common (87.5%) compared with 75% of those diagnosed during their pregnancy. Conclusion: Women diagnosed with CFRDM were likely to require caesarean section, to be treated with insulin, and to be frequently admitted to hospital for CF exacerbations. Our review highlights the importance of good glucose control, stable cystic fibrosis before pregnancy and a multidisciplinary team approach.

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