Cystic fibrosis, atopy, asthma and ABPA

Antunes, João; Fernandes, Ana; Borrego, Luís Miguel; Leiria-Pinto, Paula; Cavaco, José E.

doi:10.1016/j.aller.2010.06.002

Cited by 28 publications

(36 citation statements)

References 85 publications

(107 reference statements)

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“…A fact that supports this assumption is the significantly higher proportion of pet owners that is sensitized against A. fumigatus compared to the non‐pet owner group. This fits with the higher proportion of pet owners with CF that developed ABPA, as allergic sensitization to A. fumigatus is one of the hallmarks of ABPA diagnosis and precedes development of ABPA . Pathogenic transmission from pet to owners does take place in patients with CF and preliminary results from our group indicated transmission of A. fumigatus from a rodent to a patient with CF .…”

Section: Discussionsupporting

confidence: 78%

Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis

Thronicke

Heger

Antweiler

et al. 2016

Pediatric Allergy Immunology

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Section: Discussionsupporting

confidence: 78%

Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis

Thronicke

Heger

Antweiler

et al. 2016

Pediatric Allergy Immunology

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“…The presence of environmental allergens has been associated with worse respiratory outcomes in other obstructive lung diseases, most notably asthma7 and COPD 8. However, with the exception of allergic bronchopulmonary aspergillosis,9 it remains unclear whether an allergic response to specific environmental exposures leads to increased respiratory morbidities in CF 10, 11. Two studies have demonstrated an association between reduced forced expiratory volume in 1 sec (FEV 1 ) and environmental allergies defined by skin testing(n = 25; P < 0.01; n = 48; P < 0.05) 12, 13.…”

Section: Introductionmentioning

confidence: 99%

Environmental allergies and respiratory morbidities in cystic fibrosis

Collaco

Morrow

Green

et al. 2012

Pediatric Pulmonology

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SUMMARY Background Cystic fibrosis (CF) is characterized by recurrent respiratory infections and progressive lung disease. Although environmental factors account for 50% of the variation in CF lung function, few specific exposures have been identified. Studies using small study samples focusing on environmental allergies in CF have had inconsistent results. Our objective was to examine the role of environmental allergies in upper and lower respiratory tract morbidities in CF. Methods A total of 1321 subjects with CF were recruited through the U.S. CF Twin-Sibling Study. Questionnaires were used to determine the presence/absence of environmental allergies. Questionnaires, chart review, and U.S. CF Foundation Patient Registry data were used to track outcomes. Results Within the study sample 14% reported environmental allergies. Environmental allergies were associated with a higher risk of sinus disease (adjusted OR: 2.68; p<0.001) and nasal polyps (adjusted OR: 1.74; p=0.003). Environmental allergies were also associated with a more rapid decline in lung function (additional −1.1%/year; p=0.001). However, allergies were associated with a later median age of acquisition of Pseudomonas aeruginosa (6.6 yo vs. 4.4 yo; log rank p=0.027). The reported use of common allergy medications, anti-histamines and leukotriene inhibitors, did not alter the frequency of respiratory morbidities. Conclusions Environmental allergies are associated with an increased risk of sinus disease and nasal polyps and a more rapid decline in CF lung function, but may have a protective effect against the acquisition of P. aeruginosa. Prospective studies are needed to confirm these associations which have implications for more aggressive management of allergies.

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“…Airway obstruction (which is reversible with bronchodilator use), seasonality, induction by allergens, a personal history of atopy (eczema or rhinitis), and a family history of asthma can be useful as predictors of asthma. ( 22 ) …”

Section: Discussionmentioning

confidence: 99%

Características funcionais pulmonares e uso de broncodilatador em pacientes com fibrose cística

Muramatu

Stirbulov

Forte³

2013

J. bras. pneumol.

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OBJECTIVE: To analyze pulmonary function parameters and pharmacodynamic response to a bronchodilator, as well as the prescription of bronchodilators, in cystic fibrosis (CF) patients. METHODS: This was a retrospective cohort study involving patients 6-18 years of age, diagnosed with CF, and followed at a referral center between 2008 and 2010. We evaluated only those patients who were able to perform pulmonary function tests (PFTs). We analyzed FVC, FEV1, and FEF25-75%, expressed as percentages of the predicted values, prior to and after bronchodilator tests (pre-BD and post-BD, respectively), in 312 PFTs. Repeated measures ANOVA and multiple comparisons were used. RESULTS: The study included 56 patients, divided into two groups: those whose PFT results spanned the 2008-2010 period (n = 37); and those whose PFT results spanned only the 2009-2010 period (n = 19). In the 2008-2010 group, there were significant reductions in post-BD FEV1 between 2008 and 2010 (p = 0.028) and between 2009 and 2010 (p = 0.036), as was also the case for pre-BD and post-BD FEF25 75% in all multiple comparisons (2008 vs. 2009; 2008 vs. 2010; and 2009 vs. 2010). In the 2009-2010 group, there were no significant differences between any of the years for any of the variables studied. Among the 312 PFTs, significant responses to the bronchodilator occurred in only 24 (7.7%), all of which were from patients for whom no bronchodilator had been prescribed during the study period. CONCLUSIONS: In the CF patients studied, there was loss of pulmonary function, indicating progressive lung disease, over time. The changes were greater for FEF25-75% than for the other variables, which suggests the initial involvement of small airways.

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Cystic fibrosis, atopy, asthma and ABPA

Cited by 28 publications

References 85 publications

Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis

Allergic bronchopulmonary aspergillosis is associated with pet ownership in cystic fibrosis

Environmental allergies and respiratory morbidities in cystic fibrosis

Características funcionais pulmonares e uso de broncodilatador em pacientes com fibrose cística

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