Cystic fibrosis in Tunisian children: a review of 32 children

Boussetta, Khédija; Khalsi, F.; Bahri, Yasmine; Belhadj, Imen; Tinsa, Faten; Messaoud, Taieb; Hamouda, S.

doi:10.4314/ahs.v18i3.24

Cited by 14 publications

(26 citation statements)

References 23 publications

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“…Tunisia Boussetta et al [27] conducted a retrospective study covering the period of 1996 to 2016 in order to include all CF patients from the Pediatric Department B of The Children's Hospital of Tunis. The sample included 32 children (14 boys and 18 girls) diagnosed with CF.…”

Section: Cf Incidence and Prevalence By Countrymentioning

confidence: 99%

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The Epidemiology of Cystic Fibrosis in Arab Countries: A Systematic Review

Hammoudeh

Gadelhaq

Hani

et al. 2021

SN Compr. Clin. Med.

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Cystic fibrosis (CF) is a genetic autosomal recessive disease that involves multiple systems. Both life quality and expectation are affected by the debilitating multi-system involvement of the disease which includes pulmonary, gastrointestinal, reproductive, and endocrine symptoms. Very few studies have covered the epidemiological aspects of the disease among Arab countries. To systematically review the available epidemiological literature on cystic fibrosis in order to describe the epidemiological state of this disease in the Arab world, this review used PubMed to search for relevant articles related to patients with cystic fibrosis, with no restriction on gender or age. Google scholar and the snowballing technique were used to locate further articles. A total of 17 articles met the inclusion criteria for this review. These articles were from Bahrain, Egypt, Jordan, Kuwait, Morocco, Oman, Saudi Arabia, Tunisia, and the United Arab Emirates. The articles scored 1.5–6.5 out of 8 on the quality assessment. The epidemiological data reported varied based on country and type of study. The establishment of CF registries is definitely a priority in the region, as well as the need for more research involving CF patients particularly those involving the epidemiological and clinical characteristics of these patients.

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Section: Cf Incidence and Prevalence By Countrymentioning

confidence: 99%

“…The diagnosis of CF was confirmed by carrying out 2 sweat tests coupled with mutational analysis. The incidence and prevalence were estimated as 1.5 new cases/year and 0.4/1000 hospitalizations, respectively [27].…”

Section: Cf Incidence and Prevalence By Countrymentioning

confidence: 99%

The Epidemiology of Cystic Fibrosis in Arab Countries: A Systematic Review

Hammoudeh

Gadelhaq

Hani

et al. 2021

SN Compr. Clin. Med.

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“…Cystic fibrosis (CF) is a serious genetic life-shortening disease transmitted in the autosomal recessive mode with an incidence rate of 1 in 4500 births in Europe and the USA (1). It is a chronic and progressive disease with diverse clinical manifestations occurring very early in childhood, sometimes from birth (2). It is dominated by exocrine pancreatic insufficiency and chronic lung infection in its classical form.…”

Section: Introductionmentioning

confidence: 99%

“…It is dominated by exocrine pancreatic insufficiency and chronic lung infection in its classical form. The prognosis and mortality of CF are tightly affected by respiratory disease (3) while its mortality rate varies from 1.8% per year in America to 30-50% in developing countries (2).…”

Section: Introductionmentioning

confidence: 99%

Is FEV1 associated with quality of life in children with cystic fibrosis? An original article

et al. 2019

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Introduction: Cystic fibrosis (CF) is a serious genetic life-shortening disease. Quality of life (QoL) measurement related to CF children is a relatively new field of research, which includes the patient’s perspective in research and clinical practice. Objectives: This study aimed to evaluate the QoL in children with CF and its association with FEV1 (forced expiratory volume in 1 second). Patients and Methods: This cross-sectional study was carried out on 7-14 years old children with CF attending children’s medical center from March 2017 to March 2018. Throat swab cultures and spirometry evaluation was performed for all patients. FEV1 was determined and the 6-min walk test (6MWT) was conducted. The patient’s psychological status was assessed using the Persian version of pediatric QoL inventory. ANOVA, t test, and chisquare tests were used for data analysis. Results: Seventy-six subjects with the mean age of 10.49±3.18 years were studied since 59% of them (n=44) were boys. The mean total QoL was 65.34±17.73. Patients with lower pulmonary function had a lower QoL. There was a significant association between FEV1 and school and emotional functioning (P=0.005 and P=0.002, respectively). A significant association was found between SPO2 (peripheral capillary oxygen saturation) reduction after 6MWT and FEV1 decline (P=0.001). Additionally, a significant association was detected between FEV1 and the distance walked during 6MWT (P=0.030). Conclusion: Regarding the association between pulmonary function and QoL in CF patients and lower QoL score in our study, the importance of assessing pulmonary function in these patients should not be neglected.

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“…Several genetic disorders come to the fore: cystic fibrosis in Tunisia23, autosomal dominant polycystic kidney disease24, and hemophilia25.…”

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confidence: 99%