Cystic fibrosis related diabetes: Medical management

Ode, Katie Larson; Chan, Christine L.; Granados, Andrea; Moheet, Amir; Moran, Antoinette; Brennan, Amanda

doi:10.1016/j.jcf.2019.08.003

Cited by 36 publications

(34 citation statements)

References 53 publications

(85 reference statements)

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“…Insulin is the recommended therapy for CFRD as well as for GDM in women with CF [85] , [86] , [87] , [100] . It is also first-line therapy for all other diabetes in pregnancy in the general population [35] , [101] .…”

Section: Treatmentmentioning

confidence: 99%

Gestational and pregestational diabetes in pregnant women with cystic fibrosis

Oxman

Roe

Ullal

et al. 2022

Journal of Clinical & Translational Endocrinology

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Highlights Women living with cystic fibrosis (CF) are increasingly pursuing pregnancy. Gestational and pregestational diabetes are highly prevalent in women with CF. Diabetes impacts fetal outcomes, and good glycemic control reduces risk of pregnancy complications. Diabetes during pregnancy in women with CF requires intensive endocrine and nutrition care, ideally incorporated into the CF multidisciplinary team.

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Section: Treatmentmentioning

confidence: 99%

Gestational and pregestational diabetes in pregnant women with cystic fibrosis

Oxman

Roe

Ullal

et al. 2022

Journal of Clinical & Translational Endocrinology

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“…Continuous subcutaneous insulin infusion (CSII), commonly known as insulin pump therapy, can be helpful in these situations as they allow repeated small bolus doses of insulin without requiring additional injections. Pumps can also be useful in patients who tend to consume a steady intake of carbohydrates throughout the day through snacking or grazing [48].…”

Section: Carbohydrate Countingmentioning

confidence: 99%

“…The choice of insulin regimen to match enteral feeds is sometimes challenging and must take into account the duration and carbohydrate content of the feeding. (Insulin management of overnight gastrostomy feedings is presented in [48]. Special formulas (i.e.…”

Section: Supplemental Feedsmentioning

confidence: 99%

Cystic fibrosis related diabetes: Nutrition and growth considerations

Kaminski

Goldsweig

Sidhaye

et al. 2019

Journal of Cystic Fibrosis

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“…The use of oral corticosteroids is a risk factor for the development of CFRD [63]. Refer to section 2.2.1.6.4 in the Medical Management of Cystic Fibrosis Related Diabetes section [75] in this issue for information regarding the treatment of steroidinduced hyperglycemia.…”

Section: Hyperglycemiamentioning

confidence: 99%

Adrenal function in cystic fibrosis

Rayas¹,

Kelly

Hughan

et al. 2019

Journal of Cystic Fibrosis

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Cystic fibrosis (CF) is not known to directly affect the adrenal gland, but commonly used CF therapies do impact the function of the hypothalamic-pituitary-adrenal (HPA) axis. By binding to the glucocorticoid receptor, medications such as inhaled and oral corticosteroids can enhance the systemic effects of cortisol and result in iatrogenic Cushing syndrome. Prolonged use suppresses the body's ability to make cortisol, resulting in iatrogenic adrenal insufficiency upon medication discontinuation. Chronic use of inhaled and oral corticosteroids can negatively affect bone health, growth, and glucose metabolism. This chapter provides practical guidelines regarding the screening, diagnosis, and treatment of iatrogenic adrenal insufficiency. As the guidelines are mainly derived from the asthma literature, this chapter also highlights the need for studies to evaluate the impact of CF therapies on adrenal function and other CF-endocrinopathies.

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Cystic fibrosis related diabetes: Medical management

Cited by 36 publications

References 53 publications

Gestational and pregestational diabetes in pregnant women with cystic fibrosis

Gestational and pregestational diabetes in pregnant women with cystic fibrosis

Cystic fibrosis related diabetes: Nutrition and growth considerations

Adrenal function in cystic fibrosis

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