Cystic Fibrosis Therapeutics

The Potential of Metal Nanoparticles for Inhibition of Bacterial Biofilms

“…It was also found that sharp debridement followed by antibiotic treatment is very promising for healing the wounds (Dowd et al, 2011). In the treatment of CF, antibiotics combination therapies, for example, fosfomycin and tobramycin, are recommended (Hoffman and Ramsey, 2013). It was also shown that mannitol enhances antibiotic susceptibility of the persister bacteria in P. aeruginosa biofilms (Barraud et al, 2013).…”

Medical Biotechnology: Problems and Prospects in Bangladesh

“…61 Currently active trials of gene therapy are going on over such varied diseases cystic fibrosis, vein graft rejection, psychiatric d i sorders, inner ear developmental anomalies, brain tumors, mitochondrial genetic diseases. [61][62][63][64][65][66][67][68][69] The use of viruses to deliver genes has shown risks to human health, making trials with these viruses controversial. Another method involves the use of liposomes, hollow membranous spheres which encapsulate the gene.…”

Editorial: Advances in Pediatric Pulmonology

“…An orally active medication, Ivacaftor has been approved, initially for use in patients with the G551D mutation, and latterly for the other Class III gating mutations. There are now several reports on mutation specific treatment for CF [2]. In this issue of IJP, Guglani has reviewed all ongoing studies on advances in treatment of CF [3].…”