Cystic Lung Changes in a Patient With Pulmonary Tuberculosis

Cystic lung tuberculosis in children: A series of five cases

“…1,4,5 Unusual CT findings for pulmonary TB are more common in a subset of patients, especially immunocompromised patients, malnourished patients, those with autoimmune deficiency syndromes, the elderly, alcoholics and those with diabetes mellitus. 6 Among the presented patients, all had varying degrees of malnutrition, but none of them were infected with HIV.…”

“…Cyst formation may be the result of granulomatous involvement of the bronchioles with a resultant check-valve mechanism caused by mural inflammation, oedematous luminal narrowing of the bronchioles by caseous material and peribronchiolar fibrosis. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 Scarring of the larger proximal bronchi with distal dilatation and interstitial air leakage with tuberculoma rupture have also been implicated in the pathogenesis. 1 , 3 , 4 , 5 , 6 , 7 Other potential mechanisms include healed tubercular cavities re-lined by epithelia, cystic bronchiectasis and cysts developing post-isoniazid treatment in some cases.…”

“… 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 Scarring of the larger proximal bronchi with distal dilatation and interstitial air leakage with tuberculoma rupture have also been implicated in the pathogenesis. 1 , 3 , 4 , 5 , 6 , 7 Other potential mechanisms include healed tubercular cavities re-lined by epithelia, cystic bronchiectasis and cysts developing post-isoniazid treatment in some cases. 1 , 4 , 7…”

“…1,2,3,4,5,6,7,8,9 Scarring of the larger proximal bronchi with distal dilatation and interstitial air leakage with tuberculoma rupture have also been implicated in the pathogenesis. 1,3,4,5,6,7 Other potential mechanisms include healed tubercular cavities re-lined by epithelia, cystic bronchiectasis and cysts developing postisoniazid treatment in some cases. 1,4,7 Most patients with tuberculosis who develop lung cysts have extensive bilateral infiltrative and exudative disease as a result of the pneumonic process.…”

The master impersonator: Pulmonary tuberculosis mimicking diffuse cystic lung disease – A mini case series of a rare presentation

“…Cyst formation in the lung due to TB has not been clearly understood, but some mechanisms have been hypothesized: a) Interstitial air leakage due to tubercle rupture (subpleural emphysema), b) Chronic granulomatous inflammation of bronchioles and caseating necrosis of the bronchiolar walls leading to dilated bronchioles by check-valve mechanism, c) Poor drainage of necrotic lung parenchyma along with bronchiolar obstruction. [ 4 5 6 ] The development of cysts attributing to isoniazid therapy was also reported. [ 7 ] Using immunohistochemical and electron microscopy investigations, it was determined that proteinases secreted by granulomas of the peribronchial lining are responsible for degradation of elastic fibers along the bronchial walls, alveolar ducts, and alveolar walls.…”