Cystic pancreatic neuroendocrine tumors: A more favorable lesion?

Carr, Rosalie A.; Bletsis, Panagiotis; Roch, Alexandra M.; House, Michael G.; Zyromski, Nicholas J.; Nakeeb, Attila; Schmidt, C. Max; Ceppa, Eugene P.

doi:10.1016/j.pan.2019.01.017

Cited by 16 publications

(15 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Neuroendocrine tumors with cystic features (cNETs) comprise 6% to 27% of all NETs of the pancreas (13% in a recent meta-analysis). 36,37 Approximately 90% of the tumors are sporadic, while 10% arise in the context of multiple endocrine neoplasia type 1 (MEN1). 37 While most cNETs are nonfunctioning, insulinomas are the most frequent type among functioning cNETs.…”

Section: Cystic Neuroendocrine Tumorsmentioning

confidence: 99%

See 1 more Smart Citation

Nonmucinous Cystic Lesions of the Pancreas

Espósito

Haeberle

2021

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

Context.— Pancreatic cystic lesions are increasingly diagnosed. Among other criteria, they are often distinguished in mucinous versus nonmucinous cysts. Mucinous pancreatic cystic lesions have received increasing attention, especially those known as precursors of pancreatic ductal adenocarcinoma. However, the group of nonmucinous cystic lesions of the pancreas includes numerous entities that may pose a diagnostic challenge. Their accurate diagnosis and classification are crucial for adequate patient management. Objective.— To review the spectrum of nonmucinous cystic lesions of the pancreas, taking into consideration their epidemiology and typical clinical context, their characteristic gross morphology and histomorphology, as well as their immunohistochemical and molecular profile. Data Sources.— Literature was searched and reviewed with MEDLINE via PubMed. Macroscopic and microscopic images were obtained from the archives of the Institute of Pathology, Heinrich Heine University and University Hospital of Duesseldorf, Germany. Conclusions.— Nonmucinous cysts of the pancreas comprise numerous, mostly rare entities displaying different biological behaviors. The most frequent are serous cystic neoplasms, solid-pseudopapillary neoplasms, cystic neuroendocrine tumors, and pancreatitis-associated pseudocysts. Accurate diagnosis can be achieved if characteristic clinical context, histomorphology, and immunoprofile are taken into account.

show abstract

Section: Cystic Neuroendocrine Tumorsmentioning

confidence: 99%

“…However, survival for patients with cNET of the pancreas seems rather similar to the survival of those with solid pancreatic NET. 36,39 EUS-FNA diagnosis is simple in specimens of adequate cellularity, owing to the characteristic histologic appearance and the typical immune profile (Figure 4).…”

Section: Cystic Neuroendocrine Tumorsmentioning

confidence: 99%

Nonmucinous Cystic Lesions of the Pancreas

Espósito

Haeberle

2021

Archives of Pathology &Amp; Laboratory Medicine

View full text Add to dashboard Cite

show abstract

“…Some cases are associated with familial syndromes such as multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau syndrome (VHL), and neurofibromatosis type 1 [2]. Cystic forms of PNET are rarely seen in clinical practice with more favorable prognosis than solid PNET [3]. Recent studies showed that cystic PNET tend to have lower tumor grade, less aggressive behavior and better long-term prognosis [3].…”

Section: Introductionmentioning

confidence: 99%

“…Cystic forms of PNET are rarely seen in clinical practice with more favorable prognosis than solid PNET [3]. Recent studies showed that cystic PNET tend to have lower tumor grade, less aggressive behavior and better long-term prognosis [3]. According to the American Joint Committee on Cancer (AJCC) and European Neuroendocrine Tumor Society (ENETS) guidelines, cystic PNET often present lower pathologic stage and decreased Ki-67 proliferation index compared with solid counterpart.…”

Section: Introductionmentioning

confidence: 99%

Total Pancreatectomy for Multicentric Cystic Neuroendocrine Tumor of the Pancreas: A Case Report

et al. 2022

View full text Add to dashboard Cite

Pancreatic neuroendocrine tumors (PNETs) are uncommon pancreatic neoplasms with malignant potential, heterogeneous clinical behavior, as well as imaging appearance. These tumors represent less than 3% of all pancreatic neoplasms with typical CT presentation as solid, well-circumscribed, hypervascular lesions. Cystic PNET is a rare pancreatic tumor which is nowadays more often detected due to the widespread use of high-resolution cross-sectional imaging. They are mainly solitary lesions most commonly localized in the body and the tail of the pancreas. Due to cystic presentation these lesions often present a diagnostic challenge to both experienced radiologists and pathologists. Herein, we present a rare case of synchronous, multiple cystic and solid pancreatic neuroendocrine tumors, which due to their extensiveness required total dudenopancreatectomy with splenectomy. Histopathological findings confirmed microscopic and macroscopic cystic components as well as typical solid variants of neuroendocrine tumors along the entire pancreas.

show abstract

“…Because of its indolent behavior, more conservative surgical procedures are proposed such as tumor enucleation and spleen preserving distal pancreatectomy, and in some selected patients, particularly those with purely cystic tumor < 2 cm, only surveillance is suggested [ 58 – 60 ]. However, preoperative radiological diagnosis of CPNET is difficult with a misdiagnosing rate up to 50% even in high-volume centers specialized in pancreatic tumors [ 55 , 56 ]; anyway, when operators are expert and when sufficient material is present for immunohistochemical staining, preoperative diagnosis can be achieved by EUS-fine needle aspiration with a diagnostic accuracy up to 100% [ 55 – 57 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

Cystic pancreatic lesions: MR imaging findings and management

2021

View full text Add to dashboard Cite

Cystic pancreatic lesions (CPLs) are frequently casual findings in radiological examinations performed for other reasons in patients with unrelated symptoms. As they require different management according to their histological nature, differential diagnosis is essential. Radiologist plays a key role in the diagnosis and management of these lesions as imaging is able to correctly characterize most of them and thus address to a correct management. The first step for a correct characterization is to look for a communication between the CPLs and the main pancreatic duct, and then, it is essential to evaluate the morphology of the lesions. Age, sex and a history of previous pancreatic pathologies are important information to be used in the differential diagnosis. As some CPLs with different pathologic backgrounds can show the same morphological findings, differential diagnosis can be difficult, and thus, the final diagnosis can require other techniques, such as endoscopic ultrasound, endoscopic ultrasound-fine needle aspiration and endoscopic ultrasound-through the needle biopsy, and multidisciplinary management is important for a correct management.

show abstract

Cystic pancreatic neuroendocrine tumors: A more favorable lesion?

Cited by 16 publications

References 23 publications

Nonmucinous Cystic Lesions of the Pancreas

Nonmucinous Cystic Lesions of the Pancreas

Total Pancreatectomy for Multicentric Cystic Neuroendocrine Tumor of the Pancreas: A Case Report

Cystic pancreatic lesions: MR imaging findings and management

Contact Info

Product

Resources

About