Cystic tumor of the liver without ovarian-like stroma or bile duct communication: two case reports and a review of the literature

Abstract

We report two cases of cystic neoplasm of the liver with mucinous epithelium in which both ovarian-like stroma and bile duct communication were absent. The first case was a 41-year-old woman. She underwent right trisegmentectomy due to a multilocular cystic lesion, 15 cm in diameter, with papillary nodular components in the medial segment and right lobe. Histologically, arborizing papillae were seen in the papillary lesion. The constituent neoplastic cells had sufficient cytoarchitectural atypia to be classified as high-grade dysplasia. The second case was a 60-year-old woman. She underwent left lobectomy due to a unilocular cystic lesion, 17 cm in diameter, in the left lobe. Histologically, the cyst wall was lined by low columnar epithelia with slight cellular atypia. In both cases, neither ovarian-like stroma nor bile duct communications were found throughout the resected specimen. According to the most recent World Health Organization (WHO) classification in 2010, cystic tumors of the liver with mucinous epithelium are classified as mucinous cystic neoplasms when ovarian-like stromata are found, and as intraductal papillary neoplasm of bile duct when bile duct communication exists. Therefore, we diagnosed the cystic tumors as ‘biliary cystadenoma’ according to the past WHO classification scheme from 2000. We believe that the combined absence of both ovarian-like stroma and bile duct communication is possible in mucinous cystic tumors of the liver. Herein, we have described the clinicopathologic features of the two cases and reviewed past cases in the literature.

A giant and insidious subphrenic biloma formation due to gallbladder perforation mimicking biliary cystic tumor: A case report

“…Given the suspected BCT, image-guided needle aspiration cytology or biopsy is not implemented, due to high false negative results and the risk of peritoneal dissemination (23). Furthermore, an elevated bilirubin concentration in the aspiration fluid cannot be considered as a conclusive parameter to discriminate bilomas from BCTs with bile duct communication (24,25). In the present case study, intraoperative detection of scattered papillomas highlighted our suspicion of BCT.…”

Biliary Mucinous Cystic Neoplasm of the Liver with Ovarian Stroma and Elevated Serum and Cystic Fluid Cancer Antigen 19-9 Levels

“…Since the presence of ovarian stroma was accepted as a prerequisite for the diagnosis of BMCNs, the distinct entity of biliary intraductal papillary mucinous neoplasms was proposed [ 4 ]. However, more than a few reports of cystic liver tumors have been published where both ovarian stroma and bile duct communication are not detected [ 5 ].…”

Mucinous Cystadenoma: A Rare Hepatic Tumor in a Child

“…Not surprisingly, case reports of female patients predominated ( 1 , 11 ). However, emerging literature describes a second variety of tumor without a mesenchymal layer, but rather a hyaline, fibroid, or myxoid stroma ( 2 , 14 ). Neither the case we present, nor 10 of the 11 previously described cases of MCA in children contained ovarian-like stroma.…”