Cystic Tumors of the Right Atrium Caused by Nonbacterial Thrombotic Endocarditis in a Patient with Large Cell Carcinoma

Abstract

P i c t u r e 1 . T h e c y s t i c t u mo r h a d a p e d i c u l u s a t t a c h e d t o t h e r i g h t a t r i u m wa l l a b o v e t h e a n t e r i o r t r i c u s p i d v a l v e wh i c h mo v e d f r o m t h e r i g h t a t r i u m c a v i t y a t t h e d i a s t o l i c p h a s e ( P i c t u r e 1 -a , b ) t o t h e r i g h t v e n t r i c u l a r c a v i t y a t t h e s y s t o l i c p h a s e ( P i c t u r e 1 -c , d ) . T h e mo r p h o l o g y o f t h e t u mo r c h a n g e d f r o m c y c l e s h a p e a t p r e -s y s t o l i c ( P i c t u r e 1 -a ) a n d e a r l y -d i a s t o l i c p e r i o d s ( P i c t u r e 1 -c ) t o a p r e s s e d s h a p e a t s y s t o l i c ( P i

Nonbacterial Thrombotic (Marantic) Endocarditis in a Patient with Colorectal Cancer

“…When present, NBTE is mostcommonlyassociatedwithmalignancies,predominantly ofadvancedstage [3,5,6].Conversely,NBTEwasobserved in19%ofatotalof200patientswithsolidtumorscompared to only 2% in the control group according to a prospective echocardiographicstudy [7].NBTEhasbeenassociatedwith carcinomas originating from almost any primary, with lung [8][9][10][11],pancreatic [12][13][14],andovarian [15][16][17][18][19]adenocarcinomas being the most common cancers involved [2]. With the exceptionofpostmortemcaseseriesexaminingtheincidence of NBTE, only a couple of cases of NBTE associated with colorectalcancerhavebeenreported [20,21].ThepathogenesisofNBTEinmalignancystillremainspartiallyelusive,although it is intimately related to cancer-associated thrombophilia,originallydescribedasTrousseau'ssyndrome [1,2].…”