2001
DOI: 10.1097/00005392-200106001-00028
|View full text |Cite
|
Sign up to set email alerts
|

Cystine Calculi in Children: The Results of a Metabolic Evaluation and Response to Medical Therapy

Abstract: Our results suggest that further investigation of low citrate excretion is needed in cystinuric children. Potassium citrate therapy is effective in increasing urinary pH and urinary citrate. However, high recurrence rate and persistent cystinuria in our patients emphasize the inadequacy of our treatment schedule in the prevention of recurrent cystine calculi.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

0
31
0
1

Year Published

2002
2002
2023
2023

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 10 publications
(32 citation statements)
references
References 15 publications
0
31
0
1
Order By: Relevance
“…Tekin et al (21) reported that 66.7% of children with cystine stones who used alpha-mercaptopropionylglycine and potassium citrate had no stones at the end of the mean followup of 15 months. Furthermore, in another study, Izol et al (22) demonstrated a 16.6% recurrence rate in patients who were receiving medical treatment and 100% in patients who did not receive any medical treatment.…”
Section: Resultsmentioning
confidence: 99%
“…Tekin et al (21) reported that 66.7% of children with cystine stones who used alpha-mercaptopropionylglycine and potassium citrate had no stones at the end of the mean followup of 15 months. Furthermore, in another study, Izol et al (22) demonstrated a 16.6% recurrence rate in patients who were receiving medical treatment and 100% in patients who did not receive any medical treatment.…”
Section: Resultsmentioning
confidence: 99%
“…There have been no reports in humans. Urinary cystine stones are mainly induced by cystinuria, an inborn error of metabolism [12-15]. Supersaturation of cystine in the urine leads to the precipitation of cystine crystals, and subsequent formation of cystine stones.…”
Section: Discussionmentioning
confidence: 99%
“…data. It was estimated that 4 subjects per treatment were required to provide approximately 83% power to detect a mean urine pH difference of 1 between any ADV7103 dose group and placebo at the two-sided 5% significance level at the end of Period I. Powering assumed a residual standard deviation equal to 0.4, based on literature data 9,10 , and no correction for multiple comparisons. Randomisation to one of the four possible treatment sequences (see Table 1) was performed in a balanced manner and in accordance with a randomisation table.…”
Section: Methods Formulation Developmentmentioning
confidence: 99%
“…The PD analysis set included all subjects who received treatment and had valid PD data. It was estimated that 4 subjects per treatment were required to provide approximately 83% power to detect a mean urine pH difference of 1 between any ADV7103 dose group and placebo at the two-sided 5% significance level at the end of Period I. Powering assumed a residual standard deviation equal to 0.4, based on literature data 9 , 10 , and no correction for multiple comparisons.…”
Section: Methodsmentioning
confidence: 99%