Cystosarcoma Phyllodes Mammae

Maier, W; Rosemond, George P.; Wittenberg, P.; Tassoni, E.M.

doi:10.1159/000224446

Cited by 26 publications

(15 citation statements)

References 11 publications

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“…21 In some patients a lesion may have been apparent for several years, with clinical presentation precipitated by a sudden increase in size 722 23Malignant tumours are often larger and faster growing, but size and growth rate per se are poor predictors of the final histopathological type 810 21-25 They are found more commonly in the upper outer quadrant with an equal propensity to occur in either breast 7…”

Section: Diagnosismentioning

confidence: 99%

Phyllodes tumours

Parker

Harries

2001

Postgraduate Medical Journal

297

345

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Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of all breast neoplasms. With the non-operative management of fibroadenomas widely adopted, the importance of phyllodes tumours today lies in the need to diVerentiate them from other benign breast lesions. All breast lumps should be triple assessed and the diagnosis of a phyllodes tumour considered in women, particularly over the age of 35 years, who present with a rapidly growing "benign" breast lump. Treatment can be by either wide excision or mastectomy provided histologically clear specimen margins are ensured. Nodal metastases are rare and routine axillary dissection is not recommended. Few reliable clinical and histological prognostic factors have been identified. Local recurrence occurs in approximately 15% of patients and is more common after incomplete excision. It can usually be controlled by further surgery. Repeated local recurrence has been reported without the development of distant metastases or reduced survival. Approximately 20% of patients with malignant phyllodes tumours develop distant metastases. Long term survival with distant metastases is rare. The role of chemotherapy, radiotherapy, and hormonal manipulation in both the adjuvant and palliative settings remain to be defined. (Postgrad Med J 2001;77:428-435)

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Section: Diagnosismentioning

confidence: 99%

Phyllodes tumours

Parker

Harries

2001

Postgraduate Medical Journal

297

345

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“…Patients have noted small lumps in their breasts for as many as 45 years before the nodule began to grow and the diagnosis of cystosarcoma phyllodes was made (Maier et al, 1968). Some authors feel that the lesion also can arise de novo from breast parenchyma (Dyer et al, 1966;Hafner et al, 1962;Treves, 1964).…”

Section: Etiologymentioning

confidence: 99%

“…If pain and ulceration do occur, they are almost always the direct result of a bulky tumor producing avascular necrosis (Geist, 1964) and a resultant infection of the ulceration (Treves, 1964); pain and ulceration do not indicate malignancy. Usually the tumor is multilobular, non-tender, (Maier et al, 1968) not attached to skin, and freely movable (Carpathios and Raftery, 1960). A benign lesion may attach to the pectoralis fascia and become somewhat fixed (Hafner et al, 1962), a phenomenon which spoils the usefulness of a physical finding that indicates malignancy; invasion of the pectoralis major muscle with resultant fixation of the tumor mass (Hafner et al, 1962).…”

Section: Clinical Featuresmentioning

confidence: 99%

Metastatic cystosarcoma phyllodes: A case report and review of the literature

Kessinger¹,

Foley²,

Lemon³

et al. 1972

Journal of Surgical Oncology

149

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The breast tumor cystosarcoma phyllodes probably does not Rpresent an entity, but rather a spectrum of disease including a benign form, a histologically malignant form, and a metastatic form. In an attempt to better understand the metastatic variant, all 66 cases which could be found in the english literature and an additional case from this institution were reviewed.The tumor often arises from a fibroadenoma, but its etiology is uncertain. Factors that determine the benignity or malignancy of the tumor are unknown, but a lower fertility rate in patients with metastases warrants interest.Incidence is low; cystosarcoma makes up about 0.5% of alI breast tumors and only 3-12% of these are metastatic.The tumor presents as a breast mass, often of large size, but there is no clinical feature peculiar to the metastatic variant.Gross and microscopic pathologic findings cannot accurately forecast the metastatic potential of the tumor, but are of more predictive value than the clinical presentation. The clinical course is the only sure means of determining metastatic potential at present.

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“…A simple intracapsular enucleation (referred to as ‘enucleation of the phyllodes tumour') results in high local recurrence rates regardless of the histological type. Should a diagnosis of phyllodes tumour be established preoperatively, wide excision should be performed with tumour-free margins of at least 1 cm from the normal breast tissue, especially in the case of borderline and malignant tumour forms [98,99,100,101,102,103,104]. …”

Section: Mixed Fibroepithelial Tumoursmentioning

confidence: 99%

Benign Breast Tumours - Diagnosis and Management

et al. 2018

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With improvements in breast imaging, mammography, ultrasound and minimally invasive interventions, the detection of early breast cancer, non-invasive cancers, lesions of uncertain malignant potential, and benign lesions has increased. However, with the improved diagnostic capabilities comes a substantial risk of false-positive benign lesions and vice versa false-negative malignant lesions. A statement is provided on the manifestation, imaging, and diagnostic verification of isolated benign breast tumours that have a frequent manifestation, in addition to general therapy management recommendations. Histological evaluation of benign breast tumours is the most reliable diagnostic method. According to the S3 guideline and information gained from analysis of the literature, preference is to be given to core biopsy for each type of tumour as the preferred diagnostic method. An indication for open biopsy is also to be established should the tumour increase in size in the follow-up interval, after recurring discrepancies in the vacuum biopsy results, or at the request of the patient. As an alternative, minimally invasive procedures such as therapeutic vacuum biopsy, cryoablation or high-intensity focused ultrasound are also becoming possible alternatives in definitive surgical management. The newer minimally invasive methods show an adequate degree of accuracy and hardly any restrictions in terms of post-interventional cosmetics so that current requirements of extensive breast imaging can be thoroughly met.

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Cystosarcoma Phyllodes Mammae

Cited by 26 publications

References 11 publications

Phyllodes tumours

Phyllodes tumours

Metastatic cystosarcoma phyllodes: A case report and review of the literature

Benign Breast Tumours - Diagnosis and Management

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