Cystosarcoma phylloides

Dyer, N. H.; Bridger, J E; Taylor, R S

doi:10.1002/bjs.1800530517

Cited by 60 publications

(43 citation statements)

References 12 publications

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“…PTs of the breast are rare, representing <1% of all breast neoplasms (1,2). The WHO categorizes these tumors as benign, borderline, and malignant, based on histopathologic characteristics (4).…”

Section: Discussionmentioning

confidence: 99%

Is the extent of surgical resection important in patient outcome in benign and borderline phyllodes tumors of the breast?

Sevinç¹,

Aksoy²,

Durak³

et al. 2018

Turk J Med Sci

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Background/aim: Phyllodes tumors (PTs) of the breast are rare, and their diagnosis and treatment remain controversial. This retrospective study aims to examine the clinical outcome of benign and borderline PTs, according to the surgical margins. Materials and methods:We examined the medical records of 122 patients in our clinic, who had histologically confirmed benign and borderline PTs between 1994 and 2017. Results:The mean age of the patients was 40.6 years (range 18.0-81.0, ±12.1 standard deviation [SD]) and the mean tumor size was 25.8 mm (range 9-65, ±10.3 SD). All patients underwent a breast-conserving procedure and the median follow-up was 51 months. Tumor margins were positive (tumor touching the ink) in 43 patients (35%). Only 16 patients (13%) had margins ≥10 mm. The margins were between 2 and 10 mm in most patients (40%) and ≤1 mm in 12% of the patients. Conclusion:Although no re-excision was performed to obtain grossly clear margins, local recurrence was not observed in any patients. Therefore, revision surgery for close or positive surgical margins for benign and borderline PTs should not be performed as a rule. As most tumors recur within 2 years of diagnosis, we propose a close clinical and imaging follow-up during this period.

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Section: Discussionmentioning

confidence: 99%

Is the extent of surgical resection important in patient outcome in benign and borderline phyllodes tumors of the breast?

Sevinç¹,

Aksoy²,

Durak³

et al. 2018

Turk J Med Sci

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“…Large lesions may be associated with dilated veins visible over the skin, which may be stretched and attenuated. Rare findings which have been reported are Nipple retraction (4, 11), skin ulceration invasion of the chest wall (4,12,13), and bloody nipple discharge (13). Axillary lymph nodes are usually not involved however reactionary inflammatory lymph nodes are seen in about 20% cases (14) Surgery remains the mainstay of treatment however the extent of surgical approach historically has been controversial, and continues to evolve.…”

Section: Discussion Discussionmentioning

confidence: 99%

Recurrent Giant Phyllodes Tumour in a Young Female: A Case Report

Koshariya¹,

Sharma²,

Gehlot³

et al. 2016

JTMR

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Phyllodes tumors (PTs) are uncommon neoplasms of the breast, constituting 0.3 to 0.9% of all breast tumors in females comprised of both stromal and epithelial elements. The term cystosarcoma phyllode was coined by Johannes Muller, a misleading term as tumors are rarely cystic and the majority follow a benign clinical course. The term giant phyllodes is used when the tumor size exceeds 10 cm in diameter. WHO (World Health Organization) classification has identified three categories of phyllodes tumors of the breast (PT): benign, borderline and malignant. The mainstay of treatment of non-metastatic phyllodes tumors of the breast is complete surgical resection with wide resection margins. Local recurrence up to 50 % after surgery has been reported in Phyllodes tumors. We report a case of two episodes of recurrent phyllodes tumor in a young female.

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“…[1][2][3] First described by Johannes Müller in 1838, he coined the term cystosarcoma phyllodes; a misleading description as the tumours are rarely cystic and the majority follow a benign clinical course. In total, more than 60 synonyms have been reported but today, the World Health Organisation regards phyllodes tumour as the most appropriate nomenclature.…”

Section: Introductionmentioning

confidence: 99%

Fibroadenoma in an operated case of malignant phyllodes tumour: a rare case report

et al. 2017

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Phyllodes tumours are rare fibroepithelial lesions that account for less than 1% of breast neoplasms. Displaying a broad range of clinical and pathological behaviour, phyllodes tumours should be regarded as a spectrum of fibroepithelial neoplasms rather than a single disease entity. We would like to present a rare presentation of fibroadenoma over site of a previously operated case of malignant phyllodes tumour. A 36 year old female came to OPD with complaints of lump in both breasts since 4 months. She gave history of previous surgery, i.e., left breast lumpectomy for which HPE report was suggestive of malignant phyllodes tumour. On examination, 3x2 cm, solitary, firm to hard, non-tender lump was felt in the junction of the upper outer and inner quadrant just below the scar of previous surgery and was not freely mobile and appeared fixed to the scar. Patient underwent excision of the lump with frozen section and final HPE report turning out to be fibroadenoma. Though diagnosis of malignant phyllodes tumour is not difficult, diagnosis of low grade phyllodes tumour and distinction from fibroadenoma on FNA is difficult due to overlapping features between the two lesions. Surgery remains the mainstay of treatment for patients with cystosarcoma phyllodes, extent of surgery been controversial, and continues to evolve. Incidence of fibroadenoma occurring at the previous operated site of malignant phyllodes tumour is very rare with no known previous documentation of such a case.

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Cystosarcoma phylloides

Cited by 60 publications

References 12 publications

Is the extent of surgical resection important in patient outcome in benign and borderline phyllodes tumors of the breast?

Is the extent of surgical resection important in patient outcome in benign and borderline phyllodes tumors of the breast?

Recurrent Giant Phyllodes Tumour in a Young Female: A Case Report

Fibroadenoma in an operated case of malignant phyllodes tumour: a rare case report

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