Cysts and Swellings: A Systematic Review of the Association Between Polycystic Kidney Disease and Abdominal Aortic Aneurysm

Bailey, Marc A.; Griffin, Kathryn J.; Windle, Adam L.; Lines, Simon W.; Scott, D.

doi:10.1016/j.avsg.2012.05.013

Cited by 15 publications

(12 citation statements)

References 37 publications

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“…More recently, a review article from Perrone et al suggested that vascular complications of AAD in ADPKD are uncommon [ 7 ]. This issue, therefore, raises a suggestion from a systemic review [ 27 ] by Bailey et al that larger multicenter trials are needed because there has no enough clinical evidence to support a strong association between ADPKD and abdominal aortic aneurysm (AAA). The authors remarked that current available data are insufficient to support for establishing a regular strategy for routine screening of vascular complications in ADPKD [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

Sung

Chiang

et al. 2017

Oncotarget

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Although cardiovascular complications are the most common cause of death in patients with autosomal-dominant polycystic kidney disease (ADPKD), the incidence and risk of aortic aneurysm and dissection (AAD) in ADPKD remains unclear due to limited data and insufficient cases. We utilized the data from Taiwan National Health Insurance Research Database (NHIRD) to do a population-based cohort study (1997-2008). After excluding those patients with age <18 years old and initially concomitant diagnoses of end-stage renal disease and AAD, a total of 2076 ADPKD patients were selected from 1,000,000 of general population. Additionally, the non-ADPKD group was set up as comparison group in 1:10 ratio after matching with age, gender, income and urbanization (n=20760). The result showed that ADPKD group had higher frequency of comorbidities than non-ADPKD group. The frequency of AAD in ADPKD was significantly higher than in general population (0.92% v.s. 0.11%, p<0.0001). Of them, 58% of AAD were acute aortic dissection. In addition, Kaplan-Meier analysis demonstrated that cumulative incidence of AAD was remarkably higher in the ADPKD than non-ADPKD group (p<0.001). The mean time period from ADPKD diagnosis to AAD occurrence was 4.02±3.16 years. After adjusting for age, gender and comorbidities, the ADPKD patients had up to 5.49-fold greater risk for AAD occurrence as compared to non-ADPKD counterparts (95% CI 2.86-10.52, p<0.0001). Particularly, those patients with co-existing ADPKD and hypertension had very high risk for future development of AAD. In conclusion, the risk of AAD significantly increases in patients with ADPKD as compared with those of general population.

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Section: Discussionmentioning

confidence: 99%

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

Sung

Chiang

et al. 2017

Oncotarget

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“…These studies also demonstrate more severe diverticular disease in patients with ADPKD requiring a higher rate of surgical intervention. There are also conflicting reports regarding the association of AAA with ADPKD, but the latest reports conclude that there is no definite association [ 7 ]. Similarly, there are also discussions around the apparent association of dissection of the thoracic aorta with ADPKD [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

Yersinia pseudotuberculosis aortitis in a patient with diverticulosis and polycystic kidney disease

McCloskey

Haslam

Price

et al. 2015

Oxford Medical Case Reports

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An 81-year-old gentleman with chronic kidney disease presented with pyrexia and a new systolic cardiac murmur. Investigations revealed infective aortitis of a pre-existing aortic aneurysm graft repair. Peripheral blood cultures were positive for Yersinia pseudotuberculosis and the patient was successfully treated with an extended course of antibiotics. Abdominal imaging also revealed progressive bilateral polycystic kidney disease with associated diverticular disease, which was postulated as the source of the Y. pseudotuberculosis. An autosomal dominant polycystic kidney disease may present late in life and extra-renal manifestations of this disease are an important cause of morbidity.

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“…In humans, ADPKD is also associated with aneurysms, which appear at a much greater incidence than in the rest of the population. The few studies that have assessed the frequency of aneurysms in the aorta report a higher prevalence from 1 to 10% in ADPKD patients [11,[38][39][40] . However, down-regulation of PKD1 in dissected human aortas has also been found independently of ADPKD in a gene expression profile analysis of patients that suffered acute aortic dissection of the ascending aorta, without having any other genetic background (e.g.…”

Section: Discussionmentioning

confidence: 99%

Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm

Charolidi

Pirianov²,

Torsney³

et al. 2015

J Vasc Res

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Peroxisome proliferator-activated receptor γ agonists have been shown to inhibit angiotensin II (AngII)-induced experimental abdominal aortic aneurysms. Macrophage infiltration to the vascular wall is an early event in this pathology, and therefore we explored the effects of the peroxisome proliferator-activated receptor γ agonist pioglitazone on AngII-treated macrophages. Using microarray-based expression profiling of phorbol ester-stimulated THP-1 cells, we found that a number of aneurysm-related gene changes effected by AngII were modulated following the addition of pioglitazone. Among those genes, polycystic kidney disease 1 (PKD1) was significantly up-regulated (multiple testing corrected p < 0.05). The analysis of the PKD1 proximal promoter revealed a putative early growth response 1 (EGR1) binding site, which was confirmed by chromatin immunoprecipitation (ChIP) and quantitative PCR. Further analysis of publicly available ChIP-sequencing data revealed that this putative binding site overlapped with a conserved EGR1 binding peak present in 5 other cell lines. Quantitative real-time PCR showed that EGR1 suppressed PKD1, while AngII significantly up-regulated PKD1, an effect counteracted by pioglitazone. Conversely, in EGR1 short hairpin RNA lentivirally transduced THP-1 cells, reduced EGR1 led to a significant up-regulation of PKD1, especially after treatment with pioglitazone. In vivo, deficiency of Egr1 in the haematopoietic compartment of mice completely abolished the incidence of CaCl₂-induced aneurysm formation.

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Cysts and Swellings: A Systematic Review of the Association Between Polycystic Kidney Disease and Abdominal Aortic Aneurysm

Cited by 15 publications

References 37 publications

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

Risk of aortic aneurysm and dissection in patients with autosomal-dominant polycystic kidney disease: a nationwide population-based cohort study

Yersinia pseudotuberculosis aortitis in a patient with diverticulosis and polycystic kidney disease

Pioglitazone Identifies a New Target for Aneurysm Treatment: Role of Egr1 in an Experimental Murine Model of Aortic Aneurysm

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