Cytidine-Derived Hydrogels with Tunable Antibacterial Activities

Bhattacharyya, Tanima; Chaudhuri, Ritapa; Das, Kaustav; Mondal, Raju; Mandal, Subhranshu

doi:10.1021/acsabm.9b00438

Cited by 19 publications

(22 citation statements)

References 28 publications

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“…The linear viscoelastic region was shown in the Figure 2a. Interestingly, the gel material also exhibits thixotropic behaviour, [49] i.e. if we shake the Fe‐BTC gel vigorously, the gel state transformed to sol state while sol state again changes to gel state when kept at rest (Figure S5).…”

Section: Resultsmentioning

confidence: 99%

Design of Dual Purpose Fe‐metallogel for Magnetic Refrigeration and Fabrication of Schottky Barrier Diode

et al. 2022

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The impetus for the present work was to design multifunctional inorganic materials that can be utilized in their original assynthesized state of the matter. Accordingly, we have successfully designed a benzene-tricarboxylic acid based dual-purpose Fe-metallogel that can be used as an efficient material for cryogenic magnetic cooling as well as electronic device fabrication as Schottky barrier diode in their original gel state. The metallogel shows remarkable mechanical strength, selfsustainability and thixotropic behaviour. The gel sample has been thoroughly characterized using IR, UV-Vis spectroscopy, SEM, TEM, AFM techniques, XPS and Mössbauer spectroscopy. The porous nature, which forms the basis of the current gel based MCE study and SBD fabrication, was confirmed with gas sorption data. The porous metallogel network with by-default entrapped anion and protic solvents of the fabricated electrical device provides an excellent platform for charge transportation with a corroborating conductivity value of 4.53 × 10 À 6 Sm À 1 . As if to complement the notion of multifunctional material, the magnetic studies on the Fe-gel show significant cryogenic magnetic cooling behaviour. The theoretical result calculated using DFT are found to be highly consistent with the experimental results of the metallogel. Furthermore, we have evaluated the potential of the compound as a fuel cell membrane with detailed proton conductivity measurements on the xerogel, showing an encouraging value of 4.58 × 10 À 4 S/ cmat 95 % relative humidity and 75 °C temperature.

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Section: Resultsmentioning

confidence: 99%

Design of Dual Purpose Fe‐metallogel for Magnetic Refrigeration and Fabrication of Schottky Barrier Diode

et al. 2022

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“…Cytidine derivatives have also been evaluated in the literature for their potential usage as antibacterial agents and for wound healing purposes. Two examples of this type of gelator formed hydrogels by combining silver nitrate, silver acetate, or boric acid, with cytidine [ 142 , 143 ]. The resulting hydrogels had inherent antibacterial activity from the silver ions, which are well-known antibiotics [ 142 , 143 ].…”

Section: Applications Of Sugar-based Lmwgsmentioning

confidence: 99%

“…Two examples of this type of gelator formed hydrogels by combining silver nitrate, silver acetate, or boric acid, with cytidine [ 142 , 143 ]. The resulting hydrogels had inherent antibacterial activity from the silver ions, which are well-known antibiotics [ 142 , 143 ]. The hydrogel with silver nitrate was able to inhibit the growth of Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa and growth decreased as the volume of the hydrogel increased [ 142 ].…”

Section: Applications Of Sugar-based Lmwgsmentioning

confidence: 99%

“…On the other hand, the hydrogel made from the addition of silver acetate was not very effective against Streptococcus pneumoniae and Staphylococcus aureus, but was more potent against a multidrug resistant strain of Morganella morganii , Pseudomonas aeruginosa , Klebsiella pneumoniae and Escherichia coli . Interestingly, the hydrogel that was made with silver acetate did not discolor the tissues at the application site, leading the authors to suggest that this is advantageous over using silver nitrate in antibacterial gels [ 143 ].…”

Section: Applications Of Sugar-based Lmwgsmentioning

confidence: 99%

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Recently Developed Carbohydrate Based Gelators and Their Applications

Morris

Bietsch

Bashaw

et al. 2021

Gels

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Carbohydrate based low molecular weight gelators have been an intense subject of study over the past decade. The self-assembling systems built from natural products have high significance as biocompatible materials and renewable resources. The versatile structures available from naturally existing monosaccharides have enriched the molecular libraries that can be used for the construction of gelators. The bottom-up strategy in designing low molecular weight gelators (LMWGs) for a variety of applications has been adopted by many researchers. Rational design, along with some serendipitous discoveries, has resulted in multiple classes of molecular gelators. This review covers the literature from 2017–2020 on monosaccharide based gelators, including common hexoses, pentoses, along with some disaccharides and their derivatives. The structure-based design and structure to gelation property relationships are reviewed first, followed by stimuli-responsive gelators. The last section focuses on the applications of the sugar based gelators, including their utilization in environmental remediation, ion sensing, catalysis, drug delivery and 3D-printing. We will also review the available LMWGs and their structure correlations to the desired properties for different applications. This review aims at elucidating the design principles and structural features that are pertinent to various applications and hope to provide certain guidelines for researchers that are working at the interface of chemistry, biochemistry, and materials science.

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“…Naturally occurring supramolecular architectures such as DNA, RNA, and proteins have always inspired the scientific community to utilize supramolecular self-assembly as a tool to design and construct artificial molecular systems. − In target-guided synthesis (TGS), biological targets like proteins, nucleic acids, and so on irreversibly assemble their own best binders from a discrete pool of molecular fragments (in situ). − It is known that the close proximity of reactants in precise orientation is one of the primary conditions for bond formation to occur. Therefore, the binding of the reactant units to these templates serves this purpose by bringing the dispersed molecular units together and by facilitating predefined interactions between them, leading to the formation of the desired products. − …”

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confidence: 99%

Supramolecular Template-Directed In Situ Click Chemistry: A Bioinspired Approach to Synthesize G-Quadruplex DNA Ligands

Bhattacharyya

Panda

2021

Org. Lett.

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The assembly of guanosine and boronic acids produces anionic hydrogels (G−B hydrogels) that mimic the topology of the DNA G-quadruplex. We herein demonstrate an unconventional approach of using the G−B hydrogel as a supramolecular template that assembles the irreversible formation of DNA G-quadruplexselective 1,4-triazole ligands from a pool of alkyne−azide building blocks. These generated ligands could also stabilize and strengthen the gel assembly.

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Cytidine-Derived Hydrogels with Tunable Antibacterial Activities

Cited by 19 publications

References 28 publications

Design of Dual Purpose Fe‐metallogel for Magnetic Refrigeration and Fabrication of Schottky Barrier Diode

Design of Dual Purpose Fe‐metallogel for Magnetic Refrigeration and Fabrication of Schottky Barrier Diode

Recently Developed Carbohydrate Based Gelators and Their Applications

Supramolecular Template-Directed In Situ Click Chemistry: A Bioinspired Approach to Synthesize G-Quadruplex DNA Ligands

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