Cyto-genotoxic evaluation of novel anti-tubercular copper (II) complexes containing isoniazid-based ligands

Fregonezi, Nathália Ferreira; Souza, Fabiana Aparecida; Aleixo, Nadia Andrade; Gomes, Pietra Stefany da Silva; Silvestre, Rafaela Baldassari; Grandis, Rone Aparecido De; Silva, Patrícia Bento da; Pavan, Fernando Rogério; Chorilli, Marlus; Resende, Flávia Aparecida

doi:10.1016/j.yrtph.2020.104653

Cited by 4 publications

(2 citation statements)

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“…The nano-sized drug delivery systems increased their antimycobacterial activity, decreased cytotoxicity against the Vero cell line, and consequently improved the selectivity index [122]. A recent study on the cyto-genotoxicity of Cu(II) compounds 116-118 with INH was conducted by Fregonezi et al and also concluding that the compounds show no cytotoxicity in therapeutic doses [123].…”

Section: Drug-based Copper Coordination Compoundsmentioning

confidence: 99%

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Copper Coordination Compounds as Biologically Active Agents

Krasnovskaya

Naumov

Guk

et al. 2020

IJMS

130

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Copper-containing coordination compounds attract wide attention due to the redox activity and biogenicity of copper ions, providing multiple pathways of biological activity. The pharmacological properties of metal complexes can be fine-tuned by varying the nature of the ligand and donor atoms. Copper-containing coordination compounds are effective antitumor agents, constituting a less expensive and safer alternative to classical platinum-containing chemotherapy, and are also effective as antimicrobial, antituberculosis, antimalarial, antifugal, and anti-inflammatory drugs. 64Cu-labeled coordination compounds are promising PET imaging agents for diagnosing malignant pathologies, including head and neck cancer, as well as the hallmark of Alzheimer’s disease amyloid-β (Aβ). In this review article, we summarize different strategies for possible use of coordination compounds in the treatment and diagnosis of various diseases, and also various studies of the mechanisms of antitumor and antimicrobial action.

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Section: Drug-based Copper Coordination Compoundsmentioning

confidence: 99%

“…Chemical structures of coordination compounds 116-118 based on the antituberculosis drug isoniazid.A recent study on the cyto-genotoxicity of Cu(II) compounds 116-118 with INH was conducted by Fregonezi et al and also concluding that the compounds show no cytotoxicity in therapeutic doses[123].…”

mentioning

confidence: 99%