Cytoarchitectural and Axonal Maturation in Human Auditory Cortex

Moore, Jean K.; Guan, Yue-Ling

doi:10.1007/s101620010052

Cited by 271 publications

(190 citation statements)

References 11 publications

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“…Human auditory cortex is known to have an extended period of anatomical development (Moore and Guan, 2004). The current data demonstrate aspects of this continuing development through maturation of the CAEP, and which are consistent with findings from other laboratories (Johnstone et al, 1996;Oades et al, 1997;Ponton et al, 2000Ponton et al, , 2002.…”

Section: Maturation Effectssupporting

confidence: 91%

“…These differences indicate continuing maturation of basic sound detection processes. Continued development of auditory cortex, such as volumetric changes in the cytoarchitecture (Moore and Guan, 2004), maturation of synaptic efficacy (e.g., increase in the amount of transmitter released at the presynaptic terminal) and continuation of myelin formation of axons, likely contributes to the modification in CAEP morphology observed at the scalp (Eggermont, 1985(Eggermont, , 1988.…”

Section: Maturation Effectsmentioning

confidence: 99%

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The maturation of human evoked brain potentials to sounds presented at different stimulus rates

et al. 2008

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The current study assessed the normal development of cortical auditory evoked potentials (CAEPs) in humans presented with pure tone stimuli at relatively fast stimulus rates. Traditionally, maturation of sound processing indexed by CAEPs has been studied in paradigms using inter-stimulus intervals (ISIs) generally slower than 1 Hz. While long ISIs may enhance the amplitude of CAEP components, speech information generally occurs at more rapid rates. These slower rates of sound presentation may not accurately assess auditory cortical functions in more realistic sound environments. We examined the effect of temporal rate on the elicitation of the P1-N1-P2-N2 components to unattended sounds at four levels of stimulus onset asynchrony (SOA, onset to onset, 200, 400, 600, and 800 ms) in children grouped separately by year (ages 8, 9, 10, 11 years), in adolescents (age 16 years) and in one group of young adults (ages 22-40 years). We found that both age and stimulus rate produced profound changes in CAEP morphology. Between the ages of 8-11 years, the P1 and N2 components dominated the ERP waveform at all stimulus rates. N1, the dominant CAEP component in adults, appeared as a bifurcation in a broad positive peak at earlier ages, and did not emerge as a separate component until adolescence. While the P1-N1-P2 components are more "adult-like" than "child-like" in the adolescent subjects, the N2 component, a hallmark of the child obligatory response, was still present. Faster rates resulted in the suppression of discrete components such that by 200 ms, only P1 in the adults and adolescents, and both P1 and N2 in the youngest children were discernable. We conclude that both age and ISI are important variables in the assessment of auditory cortex function and maturation. The presence of N2 in adolescents indicates that auditory cortical maturation persists into teen years.

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Section: Maturation Effectssupporting

confidence: 91%

Section: Maturation Effectsmentioning

confidence: 99%

The maturation of human evoked brain potentials to sounds presented at different stimulus rates

et al. 2008

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“…This finding implies a developmental trajectory for evoked GBA resembling that of the N1 and P2 auditory evoked responses, which develop later in childhood (Ponton et al 2000, Shahin et al 2004) and depend on the emergence of synchronous neural sources in the superficial neocortical laminae between the ages of 5-15 years (Moore and Guan 2001). Activation of synchronous neural activity underlying evoked GBA does not appear to be strictly dependent on the initial rise time of the temporal envelope of the stimuli.…”

Section: Evoked Gamma Band Activitymentioning

confidence: 72%

Music training leads to the development of timbre-specific gamma band activity

et al. 2008

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Oscillatory gamma band activity (GBA, has been shown to correlate with perceptual and cognitive phenomena including feature binding, template matching, and learning and memory formation. We hypothesized that if GBA reflects highly learned perceptual template matching, we should observe its development in musicians specific to the timbre of their instrument of practice. EEG was recorded in adult professional violinists and amateur pianists as well as in four-and fiveyear-old children studying piano in the Suzuki method before they commenced music lessons and one year later. The adult musicians showed robust enhancement of induced (non-time-locked) GBA, specifically to their instrument of practice, with the strongest effect in professional violinists. Consistent with this result, the children receiving piano lessons exhibited increased power of induced GBA for piano tones with one year of training, while children not taking lessons showed no effect. In comparison to induced GBA, evoked (time-locked) gamma band activity (30-90 Hz, ~80 ms latency) was present only in adult groups. Evoked GBA was more pronounced in musicians than non-musicians, with synchronization equally exhibited for violin and piano tones but enhanced for these tones compared to pure tones. Evoked gamma activity may index the physical properties of a sound and is modulated by acoustical training, while induced GBA may reflect higher perceptual learning and is shaped by specific auditory experiences.

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“…However, the disadvantage is that attempts to fit brain changes onto a line are over-simplified. Both cellular [35] and structural MRI [5,16] studies demonstrate that brain changes have periods of overgrowth and pruning following, mostly likely, a third-or fourth-order polynomial equation rather than a linear or curvilinear course. Attempting to fit a regression line to this function would result in missing brief windows of growth and regression.…”

Section: Incorporating Age As An Independent Variable In Meg Analysesmentioning

confidence: 99%

Practical Aspects of Running Developmental Studies in the MEG

Pang

2011

Brain Topogr

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Developmental neuroimaging studies offer a unique opportunity to gain insight into the underpinnings of various cognitive functions by examining age-related changes in brain structure and function. There is an increasing body of neuroimaging literature discussing issues related to testing children in developmental studies [8]. These deal with fMRI developmental studies and discuss methods [31], data interpretation [40], and theoretical approaches [26]. There has not yet been an equivalent discussion for MEG developmental studies. This paper will address issues specific to data acquisition, analysis, and interpretation for MEG developmental studies.

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Cytoarchitectural and Axonal Maturation in Human Auditory Cortex

Cited by 271 publications

References 11 publications

The maturation of human evoked brain potentials to sounds presented at different stimulus rates

The maturation of human evoked brain potentials to sounds presented at different stimulus rates

Music training leads to the development of timbre-specific gamma band activity

Practical Aspects of Running Developmental Studies in the MEG

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