Cytochrome b558 (p22phox) in the guinea-pig adrenal medulla

Kummer, Wolfgang; König, Peter; Höhler, Brigitte

doi:10.1002/(sici)1097-0029(19991101)47:3<215::aid-jemt8>3.0.co;2-9

Cited by 3 publications

References 33 publications

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Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K⁺‐channels—in the carotid body

Kummer

Yamamoto

2002

Microscopy Res & Technique

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The specific tissue of the carotid body is built up of groups of glomus cells, enveloped by glial-type sustentacular cells, and innervated by sensory nerve fibers. These units sense arterial pO(2) and respond to hypoxia by a variety of reactions that include initiation of the arterial chemoreflex, i.e., increasing firing activity in the carotid sinus nerve. Until now, neither the cellular localization of the initial events that lead to stimulation of chemoreceptor afferents nor the molecular mechanism of oxygen sensing in the carotid body have been unequivocally identified. Proposed molecular candidates for the mechanism of oxygen sensing include: 1). components of the mitochondrial respiratory chain, 2). NADPH oxidases generating reactive oxygen species in an oxygen-dependent manner, 3). oxygen-regulated plasmalemmal K(+)-channels, and 4). nonoxidase iron-proteins. Our still limited knowledge on their cellular distribution within the carotid body is reviewed here. It is evident that: 1). the distribution of at least some oxygen sensor candidates is not ubiquitous but cell-type-specific, and 2). each specific parenchymal cell type of the carotid body contains at least one of the proposed oxygen sensor candidates. This applies also for the glial-type sustentacular cells that exhibit immunoreactivity to the two-pore domain K(+)-channel, TASK-1. These observations fit best with the assumption that each cell type within the carotid body is principally responsive to hypoxia. The differential equipping of glomus cells, nerve endings, and sustentacular cells with sensor proteins might serve to determine different thresholds of sensitivity and/or to connect the process of oxygen sensing to different signaling pathways. It also favors the assumption that several mechanisms of oxygen sensing may act simultaneously. The cellular identification of the cell type initiating the chemoreceptor reflex, however, has to await the molecular identification of the particular oxygen sensor molecule that initiates increased carotid sinus nerve activity.

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Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K⁺‐channels—in the carotid body

Kummer

Yamamoto

2002

Microscopy Res & Technique

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Logistikmanagement als Management der Logistikfunktion

Logistikmanagement

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The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Bedard¹,

Krause²

2007

Physiological Reviews

5,937

117

5,778

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For a long time, superoxide generation by an NADPH oxidase was considered as an oddity only found in professional phagocytes. Over the last years, six homologs of the cytochrome subunit of the phagocyte NADPH oxidase were found: NOX1, NOX3, NOX4, NOX5, DUOX1, and DUOX2. Together with the phagocyte NADPH oxidase itself (NOX2/gp91phox), the homologs are now referred to as the NOX family of NADPH oxidases. These enzymes share the capacity to transport electrons across the plasma membrane and to generate superoxide and other downstream reactive oxygen species (ROS). Activation mechanisms and tissue distribution of the different members of the family are markedly different. The physiological functions of NOX family enzymes include host defense, posttranlational processing of proteins, cellular signaling, regulation of gene expression, and cell differentiation. NOX enzymes also contribute to a wide range of pathological processes. NOX deficiency may lead to immunosuppresion, lack of otoconogenesis, or hypothyroidism. Increased NOX actvity also contributes to a large number or pathologies, in particular cardiovascular diseases and neurodegeneration. This review summarizes the current state of knowledge of the functions of NOX enzymes in physiology and pathology.

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Cytochrome b558 (p22phox) in the guinea-pig adrenal medulla

Cited by 3 publications

References 33 publications

Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K⁺‐channels—in the carotid body

Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K⁺‐channels—in the carotid body

Logistikmanagement als Management der Logistikfunktion

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

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Cytochrome b558 (p22phox) in the guinea-pig adrenal medulla

Cited by 3 publications

References 33 publications

Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K+‐channels—in the carotid body

Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K+‐channels—in the carotid body

Logistikmanagement als Management der Logistikfunktion

The NOX Family of ROS-Generating NADPH Oxidases: Physiology and Pathophysiology

Contact Info

Product

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Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K⁺‐channels—in the carotid body

Cellular distribution of oxygen sensor candidates—Oxidases, cytochromes, K⁺‐channels—in the carotid body