2018
DOI: 10.1177/0960327118783543
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Cytochrome C suppresses renal accumulation and nephrotoxicity of polymyxin B

Abstract: The receptor megalin plays an important role in the accumulation of polymyxin B (PMB) in renal cells in vitro. This study aimed to examine the effects of cytochrome c (cyto c), a typical megalin ligand, on renal accumulation and nephrotoxicity of PMB in vivo. Thirty Sprague-Dawley rats were randomly divided into the vehicle control group, PMB group, PMB + cyto c 50, 100, or 200 mg/kg group, respectively, and were treated with intravenous cyto c 30 min before the administration of PMB 4.0 mg/kg once a … Show more

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Cited by 8 publications
(4 citation statements)
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“…Thus, using PMB as a comparator in this study serves to further highlight the lower renal toxicity of the MRX-8 advantage. A histopathological study was conducted on kidney tissues from the MRX-8 and PMB groups, and distinctive injury features indicative of PMB-induced AKI were observed, which is in accordance with earlier observations [26,27]. Noteworthy findings included prominent vacuolation of tubular lumens, exposed basement membranes, and crumpling of nuclei.…”
Section: Discussionsupporting
confidence: 87%
“…Thus, using PMB as a comparator in this study serves to further highlight the lower renal toxicity of the MRX-8 advantage. A histopathological study was conducted on kidney tissues from the MRX-8 and PMB groups, and distinctive injury features indicative of PMB-induced AKI were observed, which is in accordance with earlier observations [26,27]. Noteworthy findings included prominent vacuolation of tubular lumens, exposed basement membranes, and crumpling of nuclei.…”
Section: Discussionsupporting
confidence: 87%
“…Cytochrome C (cyt c) is a small mitochondrial protein (MW = 12 kDa), which is involved in the mitochondrial respiratory chain and acts downstream of p53 in the apoptotic pathway. It has been used for the treatment of carbon monoxide poisoning, hypnotic intoxication, severe hypoxia in shock, dyspnea, myocardial anoxia, and cancers [ 66 ].…”
Section: Methodsmentioning
confidence: 99%
“…However, these approaches typically include large amounts of novel, exogenous components that may complicate clinical development. Alternatively, adjuvant drugs have been co-administered along with colistin to ameliorate nephrotoxicity and neurotoxicity, including N -acetylcysteine, methionine, gelofusine, lycopene, ascorbic acid, curcumin, and cytochrome C . However, the introduction of two separate drug components, as well as determining their respective optimal doses and administration timing, complicates drug development.…”
Section: Introductionmentioning
confidence: 99%