Cytochrome P450 1A1, 2E1 and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal Cancer in the Saudi Population

Saeed, Hesham; Alanazi, Mohammad; Nounou, Howaida A.; Shalaby, Manal; Semlali, Abdelhabib; Azzam, Nahla; Aljebreen, Abdeulrahan; Alharby, Othman; Parine, Narasimha Reddy; Shaik, Jilani Purusottapatnam; Maha, Maha

doi:10.7314/apjcp.2013.14.6.3761

Cited by 23 publications

(36 citation statements)

References 44 publications

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“…CYP2E1 gene contains several genetic polymorphisms identified by RFLPs using restriction enzymes such as, Dra I, Rsa I, Pst I, and Taq I. These polymorphisms have been associated with various human cancers such as lung cancer, esophageal cancer, breast cancer, colorectal cancer and cigarette smoking-related hepatocarcinogenicity (Uematsu et al, 1992;Raunio et al, 1995;Wu et al, 1997;Lin et al, 1998;Saeed et al, 2013). CYP2E1 polymorphisms also had an effect towards drug reactions such as the pathogenesis of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in several populations Gupta et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Goh¹,

Chong²,

Chua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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CYP2E1 PstI polymorphism G-1259C (rs3813867) genotype distributions vary significantly among different populations and are associated with both diseases, like cancer, and adverse drug effects. To date, there have been limited genotype distributions and allele frequencies of this polymorphism reported in the three major indigenous ethnic groups (KadazanDusun, Bajau, and Rungus) in Sabah, also known as North Borneo. The aim of this study was to investigate the genotype distributions and allele frequencies of the CYP2E1 PstI polymorphism G-1259C in these three major indigenous peoples in Sabah. A total of 640 healthy individuals from the three dominant indigenous groups were recruited for this study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) at G-1259C polymorphic site of CYP2E1 gene was performed using the Pst I restriction enzyme. Fragments were analyzed using agarose gel electrophoresis and confirmed by direct sequencing. Overall, the allele frequencies were 90.3% for c1 allele and 9.7% for c2 allele. The genotype frequencies for c1/c1, c1/c2 and c2/c2 were observed as 80.9%, 18.8%, and 0.3%, respectively. A highly statistical significant difference (p<0.001) was observed in the genotype distributions between indigenous groups in Sabah with all Asian and non-Asian populations. However, among these three indigenous groups, there was no statistical significant difference (p>0.001) in their genotype distributions. The three major indigenous ethnic groups in Sabah show unique genotype distributions when compared with other populations. This finding indicates the importance of establishing the genotype distributions of CYP2E1 PstI polymorphism in the indigenous populations.

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Section: Introductionmentioning

confidence: 99%

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Goh¹,

Chong²,

Chua³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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“…The Saudi population may be similar to the Bahraini population but clearly differed from the Tunisian and Lebanese populations, which explains the significant differences between the study population and Tunisian and Lebanese populations. The positive assortative mating for the GSTM1 null genotype in this population may have a protective effect against common diseases in the study population or recently selected with changes in living standards, nutritional habits, and behavioral style during the last few decades, especially after the discovery and mining of petroleum in this area (Abu-Amero et al, 2006;Siraj et al, 2008;Saeed et al, 2013).…”

Section: Discussionmentioning

confidence: 91%

Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia

Mansour

Askar

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Glutathione-S-transferases (GST) are key phase II detoxifying enzymes that play critical roles in protection against products of oxidative stress and against electrophiles. Glutathione S-transferase mu (GST-M1) and theta (GST-T1) are isoforms of glutathione transferase enzymes that participate in the metabolism of a wide range of chemicals. Deletion variants that are associated with a lack of enzyme function exist at both these loci. The frequencies of homozygous GSTM1 and GSTT1 deletion carriers are very high in most of the populations studied to date. The aim of this study was to investigate the frequencies of GSTM1 and GSTT1 genotypes among the Turabah population in Saudi Arabia in comparison with the data published for some other Arabic populations. The subjects consisted of 164 unrelated healthy individuals from the Turabah population. GST genotyping was performed by multiplex polymerase chain reaction-based (2015) methods. The GSTM1 deletion homozygosity was 56.1% and GSTT1 deletion homozygosity was 20.7%, while the GSTM1 and GSTT1 doubledeletion homozygosity was 11.0%. Comparison with published data from Bahraini, Lebanese, and Tunisian populations demonstrated no significant difference for GSTM1 between these populations. The GSTT1 null-allele frequency was significantly lower than those for the Lebanese and Tunisian populations (P = 0.001) but similar to that for the Bahraini population (P = 0.099). Characterization of GST genetic polymorphisms in the Saudi population may aid in genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and the pharmacogenetics of chemotherapy.

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“…Recently, some metabolic polymorphisms are widely studied in order to understand the inheritance of cancer and individuals tolerance to tobacco carcinogens. These include cytochrome P4501A1 (CYP1A1) ile/val and glutathione-S-transferase M1 (GSTM1) null/present gene polymorphisms (Saeed et al, 2013). These genes encode such enzymes that play major roles in detoxification pathway of several carcinogens, including polycyclic aromatic hydrocarbons that are present in tobacco smoke (Shukla et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas

Tomita

Ayabe²,

Chosa³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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related with never-smoker, women, adenocarcinoma and Asians (Kosaka et al., 2004;Shigematsu et al., 2005;Mitsudomi et al., 2006). Therefore it might demonstrate the role of histology, sex, lifestyle and ethnicity as variables associated with EGFR mutation. To our knowledge, however, there is only one study that focused on EGFR mutation in men and smokers (D'Angelo et al., 2011). Of great interest, they concluded that a large number of EGFR mutations are found in adenocarcinoma tumor specimen from men and people who smoked Masaki Tomita*, Takanori Ayabe, Eiichi Chosa, Katsuya Kawagoe, Kunihide Nakamura cigarettes. In the present study, we focused on the men with adenocarcinoma patients, and we examined the relationship between EGFR mutation and clinical characteristics.

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Cytochrome P450 1A1, 2E1 and GSTM1 Gene Polymorphisms and Susceptibility to Colorectal Cancer in the Saudi Population

Cited by 23 publications

References 44 publications

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Significant Genotype Difference in the CYP2E1 PstI Polymorphism of Indigenous Groups in Sabah, Malaysia with Asian and Non-Asian Populations

Frequency of glutathione-S-transferase null-M1 and null-T1 genotypes among the Turabah population in Saudi Arabia

Epidermal Growth Factor Receptor Mutations in Japanese Men with Lung Adenocarcinomas

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