Cytochrome P450 enzyme-based biotransformation of pharmaceuticals and personal care products (PPCPs) by microalgae in the aquatic environment

Li, Shengnan; Chu, Yuhao; Ren, Nanqi; Ho, Shih-Hsin

doi:10.1016/j.cej.2023.146557

Cited by 10 publications

(2 citation statements)

References 139 publications

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“…They can transform organic pollutants, including some persistent ones, into hydrophilic compounds by adding electrophilic groups (such as -COOH). Additionally, they can further convert hydrophilic compounds into less toxic forms through processes like epoxidation and electrophilic addition [55]. However, MPs can affect this natural breakdown.…”

Section: Biodegradationmentioning

confidence: 99%

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Microplastics and Antibiotics in Aquatic Environments: A Review of Their Interactions and Ecotoxicological Implications

Tang

2024

Trop. Aqua. Soil Pollut.

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Microplastics and antibiotics are two significant emerging pollutants found together in water bodies, raising concerns about their mutual effects. This review delves into how microplastics and antibiotics interact in aqueous environments and the ecotoxicological implications of such interactions, particularly the bioavailability of antibiotics and the prevalence of antibiotic-resistance genes. It outlines that antibiotics attach to microplastics primarily through hydrophobic, hydrogen-bonding, and electrostatic interactions. Other bonds, comprising halogen bonding, cation−π interaction, and negative charge-assisted hydrogen bonds, may also be involved to better explain antibiotic adsorption patterns. The adsorption of antibiotics to microplastics often follows the pseudo-second-order kinetic model and in some instances, the pseudo-first-order kinetic model. The common adsorption isotherms governing this interaction are the linear and Freundlich models. Microplastics may increase the biodegradation of adsorbed antibiotics due to the presence of antibiotic-degrading bacteria in the biofilms. They could also hamper direct photodegradation but facilitate indirect photodegradation of adsorbed antibiotics. However, their photodegradative effect remains inconclusive. Microplastics and antibiotics exhibit significant toxicity to algae, while their effects on fish and daphnia are less noticeable, suggesting that their combination does not pose an immediate threat to the well-being and proliferation of larger aquatic organisms. In some instances, microplastics reduce the deleterious effects of antibiotics on aquatic life. Microplastics serve as catalysts for gene transfer, enhancing the propagation of antibiotic-resistance genes in these ecosystems. This review underscores the importance of understanding the regulatory mechanisms of microplastics on antibiotic-resistance gene diversity, particularly at the gene expression level.

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Section: Biodegradationmentioning

confidence: 99%

“…However, MPs can affect this natural breakdown. Studies have shown that when exposed to PS MPs, the effectiveness and quantity of CYP450 enzymes, which are crucial for breaking down antibiotics in the algae Chlorella vulgaris, are reduced [55]. This reduction hinders the biodegradation of the antibiotic levofloxacin.…”

Section: Biodegradationmentioning

confidence: 99%