Cytochrome P450 inhibitory potential of selected Indian spices — possible food drug interaction

Pandit, Subrata; Mukherjee, Kakali; Gajbhiye, Rahul L.; Venkatesh, M.; Ponnusankar, Sivasankaran; Bhadra, Santanu

doi:10.1016/j.foodres.2011.08.021

Cited by 26 publications

(16 citation statements)

References 13 publications

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“…In the present study, the selected three Indian medicinal plants ( A. paniculata , B. monnieri , C. asiatica ) along with their potent bioactive components were evaluated for determining the inhibitory potential on CYP450 enzymes and its isozymes. Standardisation of Ayurvedic medicine with corresponding bioactive compounds and their inhibitory effect on CYP 450 has been reported extensively . The present investigations are in harmony with those reports to evaluate the possible interaction potential of some herbs used as food as well as medicine in Ayurveda.…”

Section: Resultssupporting

confidence: 66%

Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study

et al. 2016

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Section: Resultssupporting

confidence: 66%

Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study

et al. 2016

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“…Inhibition of such CYP isoform should be beneficial to therapy in view of the contribution of CYP1A2 in carcinogenesis of cholangiocarcinoma (Satomi and Nishino, ). ZO was the only plant among the four candidates with promising activities against cholangiocarcinoma that showed no significant inhibitory effect on the four investigated CYP isoforms, supporting the observation by other investigators (Pandit et al ., ). ZO, commonly known as ginger, is used worldwide as a spicy flavoring agent.…”

Section: Discussionmentioning

confidence: 97%

Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450

2015

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Malaria and cholangiocarcinoma remain important public health problems in tropical countries including Southeast Asian nations. Newly developed chemotherapeutic and plant-derived drugs are urgently required for the control of both diseases. The aim of the present study was to investigate the propensity to inhibit cytochrome P450-mediated hepatic metabolism (CYP1A2, CYP2C19, CYP2D6 and CYP3A4) of the crude ethanolic extract of eight Thai medicinal plants with promising activities against malaria and cholangiocarcinoma, using human liver microsomes in vitro. Piper chaba Linn. (PC) and Atractylodes lancea (thung.) DC. (AL) exhibited the most potent inhibitory activities on CYP1A2-mediated phenacetin O-deethylation with mean IC50 of 0.04 and 0.36 µg/mL, respectively. Plumbago indica Linn. (PI) and Dioscorea membranacea Pierre. (DM) potently inhibited CYP2C19-mediated omeprazole 5-hydroxylation (mean IC50 4.71 and 6.92 µg/mL, respectively). DM, Dracaena loureiri Gagnep. (DL) and PI showed the highest inhibitory activities on dextromethorphan O-demethylation (mean IC50 2.93-9.57 µg/mL). PC, DM, DL and PI exhibited the most potent inhibitory activities on CYP3A4-mediated nifedipine oxidation (mean IC50 1.54-6.43 µg/mL). Clinical relevance of the inhibitory potential of DM, PC and PI is of concern for the further development of these plants for the treatment of malaria and/or cholangiocarcinoma.

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“…Besides the alteration of their own activity after metabolism (Cech et al, 2006), NAA containing plants (like Echinacea spp., Heliopsis spp., Piper spp., Capsicum spp.) and isolated NAAs with a terminal alkyne group inhibit P450 enzymes Pandit et al, 2012;Rodeiro et al, 2009;Subehan et al, 2006;Usia et al, 2006) and hence can also influence the metabolism of other drugs. Nevertheless, in-vitro as well as in-vivo studies showed this herb-drug interaction is clinically not significant (Toselli et al, 2009).…”

Section: Pk/pd Interactionsmentioning

confidence: 99%

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

Boonen

Bronselaer

Nielandt

et al. 2012

Journal of Ethnopharmacology

137

109

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a b s t r a c tEthnopharmacological relevance: N-Alkylamides (NAAs) are a promising group of bioactive compounds, which are anticipated to act as important lead compounds for plant protection and biocidal products, functional food, cosmeceuticals and drugs in the next decennia. These molecules, currently found in more than 25 plant families and with a wide structural diversity, exert a variety of biologicalpharmacological effects and are of high ethnopharmacological importance. However, information is scattered in literature, with different, often unstandardized, pharmacological methodologies being used. Therefore, a comprehensive NAA database (acronym: Alkamid) was constructed to collect the available structural and functional NAA data, linked to their occurrence in plants (family, tribe, species, genus). Materials and methods: For loading information in the database, literature data was gathered over the period 1950-2010, by using several search engines. In order to represent the collected information about NAAs, the plants in which they occur and the functionalities for which they have been examined, a relational database is constructed and implemented on a MySQL back-end. Results: The database is supported by describing the NAA plant-, functional-and chemical-space. The chemical space includes a NAA classification, according to their fatty acid and amine structures. Conclusions: The Alkamid database (publicly available on the website http://alkamid.ugent.be/) is not only a central information point, but can also function as a useful tool to prioritize the NAA Q8 choice in the evaluation of their functionality, to perform data mining leading to quantitative structure-property relationships (QSPRs), functionality comparisons, clustering, plant biochemistry and taxonomic evaluations.

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Cytochrome P450 inhibitory potential of selected Indian spices — possible food drug interaction

Cited by 26 publications

References 13 publications

Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study

Safety assessment of selected medicinal food plants used in Ayurveda through CYP450 enzyme inhibition study

Inhibitory Activities of Thai Medicinal Plants with Promising Activities Against Malaria and Cholangiocarcinoma on Human Cytochrome P450

Alkamid database: Chemistry, occurrence and functionality of plant N-alkylamides

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