Cytochrome P450IA1 polymorphisms along with PM10 exposure contribute to the risk of birth weight reduction

Suh, Young Ju; Kim, Byungmi; Park, Bo Hyun; Park, Hyesook; Kim, Young Ju; Kim, Ho; Hong, Yun Chul; Ha, Eun Hee

doi:10.1016/j.reprotox.2007.07.001

Cited by 10 publications

(9 citation statements)

References 38 publications

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“…[112][113][114][115] Adverse impacts on prenatal or neonatal development, e.g., restricted intrauterine growth, preterm delivery, low birth weight, congenital heart defects, and infant mortality, 5,116,117 have been associated with PM exposure during specific pregnancy trimesters. 118,119 Hence, investigations into birth outcomes targeting trimester specific effects can even utilize <1 year of data if the population of pregnant women residing in the area is large enough. [120][121][122] Long-term studies relating chronic exposure to cardiovascular disease have also benefited from only 2 to 3 years of data, and several have obtained statistically significant results using only a single year.…”

Section: Science Investigationmentioning

confidence: 99%

Advances in multiangle satellite remote sensing of speciated airborne particulate matter and association with adverse health effects: from MISR to MAIA

Diner

Boland

Bräuer

et al. 2018

J. Appl. Rem. Sens.

102

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Inhalation of airborne particulate matter (PM) is associated with a variety of adverse health outcomes. However, the relative toxicity of specific PM types-mixtures of particles of varying sizes, shapes, and chemical compositions-is not well understood. A major impediment has been the sparse distribution of surface sensors, especially those measuring speciated PM. Aerosol remote sensing from Earth orbit offers the opportunity to improve our understanding of the health risks associated with different particle types and sources. The Multi-angle Imaging SpectroRadiometer (MISR) instrument aboard NASA's Terra satellite has demonstrated the value of near-simultaneous observations of backscattered sunlight from multiple view angles for remote sensing of aerosol abundances and particle properties over land. The Multi-Angle Imager for Aerosols (MAIA) instrument, currently in development, improves on MISR's sensitivity to airborne particle composition by incorporating polarimetry and expanded spectral range. Spatiotemporal regression relationships generated using collocated surface monitor and chemical transport model data will be used to convert fractional aerosol optical depths retrieved from MAIA observations to near-surface PM 10 , PM 2.5 , and speciated PM 2.5. Health scientists on the MAIA team will use the resulting exposure estimates over globally distributed target areas to investigate the association of particle species with population

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Section: Science Investigationmentioning

confidence: 99%

Advances in multiangle satellite remote sensing of speciated airborne particulate matter and association with adverse health effects: from MISR to MAIA

Diner

Boland

Bräuer

et al. 2018

J. Appl. Rem. Sens.

102

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“…Individuals carrying the CYP1A1*2A allele are predisposed to higher DNA adduct levels and an increased percent of aberrant cells when exposed to environmental tobacco smoke (ETS) (144). Likewise, in an Asian population, the presence of the MspI polymorphism correlated with reduced birth weight following high PM10 exposure (155), oral cancer risk associated with tobacco smoking and chronic obstructive pulmonary disease (156).…”

Section: Genetic Polymorphismsmentioning

confidence: 99%

“…Additionally, the variant CYP1A1*2B or 2C (A2455G), which has an amino acid substitution of Ile462 to Val in exon 7, has been associated with higher 1-OHP (9,12,13), 2-NT (9), DNA damage (13) and PAH-DNA adducts (157) in high PAH or tobacco smoking populations, as well as reduced birth weight in pregnant women exposed to high PM10 levels (155). The interaction of smoking or (14), as well as with higher DNA adduct levels in human lung tissue (161) from PAH-exposed individuals.…”

Section: Genetic Polymorphismsmentioning

confidence: 99%

Molecular biomarkers to assess health risks due to environmental contaminants exposure

Poblete-Naredo

Albores

2016

biomedica

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<p>Los biomarcadores, o bioindicadores, son herramientas métricas que, al compararse con los valores de referencia, permiten evaluar los riesgos y generar información objetiva que ayude a las autoridades a planificar estrategias efectivas, solucionar problemas de salud o ambientales y utilizar los recursos asignados de manera eficiente.<br />La evaluación de riesgos en salud es un ejercicio multidisciplinario y la biología molecular contribuye enormemente a estos estudios, dado que el genoma, el transcriptoma, el proteoma y el metaboloma pueden verse afectados por xenobióticos, lo que causa cambios cuya medición resulta útil en la adopción de decisiones. Dichos cambios pueden variar por la carga genética de cada individuo y su distribución polimorfa en las poblaciones expuestas se convierte en un factor esencial para una adecuada interpretación de resultados.<br />Por lo tanto, el objetivo del presente artículo fue hacer una revisión de los diferentes biomarcadores moleculares aplicables a la evaluación de riesgos para la salud provenientes de los contaminantes ambientales.</p>

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“…The reason for this may be differential genetic susceptibility. Maternal genetic polymorphisms were found to modify the associations between birth weight and tobacco smoke [13-23] and birth weight and outdoor air pollution exposures [22, 24]; several studies even found independent gene effects on birth outcomes [25-27]. Two isoforms of the Glutathione S-transferase super gene family, GSTM1 and GSTT1, have been proposed as candidate genes for susceptibility to inhaled oxidants from air pollutants.…”

Section: Introductionmentioning

confidence: 99%

Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns

Thompson¹,

Yousefi²,

Peñaloza³

et al. 2014

Reproductive Toxicology

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Low birth weight is associated with exposure to air pollution during pregnancy. The purpose of this study was to evaluate whether null polymorphisms of Glutathione S-transferases (GSTs), specifically GSTM1 and GSTT1 genes in infants or mothers, modifies the association between high exposures to household air pollution (HAP) from cooking fires and birth weight. Pregnant women in rural Guatemala were randomized to receive a chimney stove or continue to use open fires for cooking. Newborns were measured within 48 hours of birth. 132 mother-infant pairs provided infant genotypes (n=130) and/or maternal genotypes (n=116). Maternal null GSTM1 was associated with a 144 gram (95% CI: -291, 1) and combined maternal/infant null GSTT1 was associated with a 155 gram (95% CI -303, -8) decrease in birth weight. Although there was a trend toward higher birth weights with increasing number of expressed GST genes, the effect modification by chimney stove use was not demonstrated.

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Cytochrome P450IA1 polymorphisms along with PM10 exposure contribute to the risk of birth weight reduction

Cited by 10 publications

References 38 publications

Advances in multiangle satellite remote sensing of speciated airborne particulate matter and association with adverse health effects: from MISR to MAIA

Advances in multiangle satellite remote sensing of speciated airborne particulate matter and association with adverse health effects: from MISR to MAIA

Molecular biomarkers to assess health risks due to environmental contaminants exposure

Genetic modification of the effect of maternal household air pollution exposure on birth weight in Guatemalan newborns

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