Cytochrome P450s: Blueprints for Potential Applications in Plants

Abstract

Cytochrome P450s belong to a particular class of enzymes (Oxygenases) which are extensively distributed in all classes of organisms that attract the interest of scientists worldwide. It has been proved multi-functioned super gene family that sophisticates the biosynthesis of several endogenous molecules and metabolism of discrete pharmacologically important oxymolecules such as Antibiotics, essential secondary metabolites, fatty acid conjugates, signaling molecules, lipid degradation, hormones and many more. In this article, we briefly overviewed the heterogeneous role of the superfamily of Cytochrome P450 based on recent advances in molecular biology and genetic engineering. The inevitable role of Cytochrome P450s proteins in the biosynthesis of secondary metabolites likewise Hormones, Flavonoids, signaling molecules and other important pigments in plants such as anthocyanin, terpenoids and their pharmacological significance are specifically focused. We have predicted the distinctive metabolic networks and molecular characteristics of Safflower genome based on extensive transcriptome analysis from various developmental stages of floral tissues. The presence of repeated sequences, high copy number coding and noncoding RNA sequences and high expression level in the petals provide a gateway to enable the development of all-inclusive gene networks for economic and clinical features of Cytochrome P450 family. The implementation of metabolic engineering in floral pigments and alteration in their biosynthetic pathways can be exploited for a comprehensive understanding of several other pathways which invites new avenues for novel therapeutic blueprints and drug development.

Identification of stable quantitative trait loci for grain yield in rice

“…The SNP markers associated with the linkage blocks M1.37719614 (qGYP1.2), M12.4534450 (qHGW12.1), M1.38398157 (qPH1), M4.28368337 (qPH4), and M7.25991230 (qPH7) would be indicated for the development and validation of (Naveed et al, 2018). The SNP marker M2.34471005 (qPH2) is located between the genes LOC_Os02g56310 (phosphoenolpyruvate carboxylase kinase 2) and LOC_Os02g56320 (starch synthase 4).…”

Spatial Genomic Resource Reveals Molecular Insights into Key Bioactive-Metabolite Biosynthesis in Endangered Angelica glauca Edgew

“…The CYPs and UGTs, which are a specific class of oxidoreductases and transferases, have been proven to be multifunctional candidates that regulate the biosynthesis and diversification of secondary metabolites [ 29 , 30 ]. In total, 602 transcripts encoding 44 CYP families were identified in A. glauca , with abundances of CYP71, CYP72, CYP76, CYP704, and CYP81.…”

Effects of Light on the Fruiting Body Color and Differentially Expressed Genes in Flammulina velutipes

“…It has been reported that the expression of CYP in blue-light-irradiated L. edodes increases with fruiting body development and shows consistently high expression at all growth stages [ 13 ]. The role of CYPs in pigment biosynthesis in plants is well known [ 53 , 54 , 55 ], but the relationship between CYPs and fruiting body color in basidiomycetes is still unclear. The biological clock controls many metabolic processes in various organisms, including microorganisms, plants, and animals.…”