Cytochrome P450s regulates aloperine-induced pathological changes in mouse liver and kidney

Qiu, Mingning; Liu, Jie; Feng, Pengfei; Su, Yongxia; Guo, Rong; Shi, Fangyun; Wang, Shuai; Zhao, Bin

doi:10.1016/j.rvsc.2020.06.005

Cited by 8 publications

(4 citation statements)

References 24 publications

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“…Aloperine is a tricyclic quinoline alkaloid isolated from Sophora vulgaris (Qiu et al, 2020;Wang et al, 2020). As discovered by Fu et al, aloperine protected against the colitis induced by DSS in the experimental mice; to be specific, aloperine administered orally at 40 mg/kg BW efficiently enhanced the DSS-mediated colitis severity, reduced the T cell ratio, and upregulated the Foxp3 levels in mesenteric lymph nodes and spleen.…”

Section: Alkaloidsmentioning

confidence: 95%

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

et al. 2021

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Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation resulting from various factors. Crohn’s disease (CD) and ulcerative colitis (UC) have been identified as the two major types of IBD. Currently, most of the drugs for IBD used commonly in the clinic have adverse reactions, and only a few drugs present long-lasting treatment effects. Moreover, issues of drug resistance and disease recurrence are frequent and difficult to resolve. Together, these issues cause difficulties in treating patients with IBD. Therefore, the development of novel therapeutic agents for the prevention and treatment of IBD is of significance. In this context, research on natural compounds exhibiting anti-inflammatory activity could be a novel approach to developing effective therapeutic strategies for IBD. Phytochemicals such as astragalus polysaccharide (APS), quercetin, limonin, ginsenoside Rd, luteolin, kaempferol, and icariin are reported to be effective in IBD treatment. In brief, natural compounds with anti-inflammatory activities are considered important candidate drugs for IBD treatment. The present review discusses the potential of certain natural compounds and their synthetic derivatives in the prevention and treatment of IBD.

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Section: Alkaloidsmentioning

confidence: 95%

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

et al. 2021

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“…A recent study by Qiu M et al pointed out that intraperitoneal (i.p.) aloperine administration induces damage in liver and kidney at the dosage of 16 mg/kg, manifested by cytoplasm vacuolization and swelling respectively (Qiu et al, 2020a). However, after withdrawing aloperine, mice would partially recover at 1 week and fully recover at 4 weeks, which indicates that the kidney and liver injury induced by high dose i.p injection of aloperine is reversible.…”

Section: Discussionmentioning

confidence: 98%

A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms

Zhou

Sun

et al. 2020

Front. Pharmacol.

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Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is appreciated for its anti-dysentry effect, a property that is commonly observed in other Sophora Genus phytomedicines. Following the rationale of reductionism, subsequent biochemical analyses attribute such anti-dysentry effect to the bactericidal activity of aloperine. From then on, the multiple roles of aloperine are gradually revealed. Accumulating evidence suggests that aloperine possesses multiple pharmacological activities and holds a promising potential in clinical conditions including skin hyper-sensitivity, tumor and inflammatory disorders etc.; however, the current knowledge on aloperine is interspersed and needs to be summarized. To facilitate further investigation, herein, we conclude the key pharmacological functions of aloperine, and most importantly, the underlying cellular and molecular mechanisms are clarified in detail to explain the functional mode of aloperine.

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“…However, in the SA group, inflammatory cells occasionally infiltrated the liver, and the number of swollen hepatocytes was reduced; only a few hepatocytes exhibited eosinophilia with deep nuclear staining, which indicated that 0.1% SA could effectively alleviate inflammatory damage in the liver. Surprisingly, after BALB/c mice were injected with 4, 8 or 16 mg/kg of aloperine for 4 weeks, Qiu et al [44] found that the cytoplasm of hepatocytes in the high-dose group was vacuolated, the epithelial cells of renal tubules were swollen, and the expression and activity of CYP450 changed; however, all the cells recovered to some extent after 1 week without the use of aloperine, and all the cells recovered completely after 4 weeks. These findings showed that aloperine has a reversible toxic effect on mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of Sophora alopecuroides in a High-Concentrate Diet on the Liver Immunity and Antioxidant Function of Lambs According to Transcriptome Analysis

An,

Wang,

Gao

et al. 2024

Animals

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The purpose of this study was to determine the effects of Sophora alopecuroides (SA) on liver function, liver inflammatory factor levels, antioxidant indexes and transcriptome in sheep. Twenty-four 3-month-old healthy Dumont hybrid lambs weighing 25.73 ± 2.17 kg were randomly divided into three groups: C1 (the control group), fed a concentrate-to-forage ratio of 50:50; H2 (the high-concentration group), fed a concentrate-to-forage ratio of 70:30; and S3 (the SA group), fed a concentrate-to-forage ratio of 70:30 + 0.1% SA. The results showed that the rumen pH values of the C1 and S3 groups were significant or significantly higher than that of the H2 group (p < 0.05 or p < 0.01). The serum ALT, AST and LDH activities and the LPS and LBP concentrations in the sheep serum and liver in the H2 group were significantly or extremely significantly higher than those in the C1 and S3 groups (p < 0.01), and the IL-10 content and SOD, GPX-PX and T-AOC activities showed the opposite trend (p < 0.05 or p < 0.01). KEGG enrichment analysis showed that the differentially expressed genes were significantly enriched in the ECM–receptor interaction and focal adhesion pathways, which are closely related to immune and antioxidant functions (p-adjust < 0.1). In summary, SA could improve the immune and antioxidant functions of lamb livers under high-concentrate conditions and regulate the mechanism of damage on sheep livers, which is caused by high-concentrate diets and through the expression of related genes in the ECM/FAs pathway.

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Cytochrome P450s regulates aloperine-induced pathological changes in mouse liver and kidney

Cited by 8 publications

References 24 publications

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

Natural Anti-Inflammatory Compounds as Drug Candidates for Inflammatory Bowel Disease

A Review on Recent Advances in Aloperine Research: Pharmacological Activities and Underlying Biological Mechanisms

Effects of Sophora alopecuroides in a High-Concentrate Diet on the Liver Immunity and Antioxidant Function of Lambs According to Transcriptome Analysis

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