Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway

Ehleben, Wilhelm; Bölling, B.; Merten, E.; Porwol, T.; Strohmaier, Anja-Rose; Acker, H.

doi:10.1016/s0034-5687(98)00078-4

Cited by 48 publications

(16 citation statements)

References 27 publications

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“…21,22 Several authors suggested that oxygen-dependent reactive oxygen species production may be involved in the down-regulation of HIF-1 activity. [32][33][34] If this is confirmed, the increase in EPO levels by NAC treatment may also involve the scavenging of reactive oxygen species and may be associated with an increased expression of other proteins under control of HIF-1 such as the vascular endothelial growth factor. These points require further investigation.…”

Section: Discussionmentioning

confidence: 95%

Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity

Hildebrandt

Alexander

Bärtsch

et al. 2002

Blood

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Section: Discussionmentioning

confidence: 95%

Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity

Hildebrandt

Alexander

Bärtsch

et al. 2002

Blood

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“…21,41 Here, however, renal-specific NADPH oxidase (NOX4) expression was induced by hypoxia, especially in SOD3 knock-out mice, which should increase ⅐ O 2 Ϫ generation and accelerate HIF-1␣ degradation. On the other hand, ⅐ O 2 Ϫ generation and H 2 O 2 release by mitochondria are required for HIF-1␣ induction and transcription of target genes in some hypoxic cells, 42,43 while other work proposes that hypoxia decreases ROS production and discounts mitochondrial ROS in HIF-1␣ stability.…”

Section: Discussionmentioning

confidence: 99%

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

Suliman

Ali

Piantadosi

2004

Blood

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“…The significance of cellular redox status in hypoxic gene expression has been suggested by recent studies (27)(28)(29)(30). Based on these studies, two hypotheses have been formulated.…”

Section: Discussionmentioning

confidence: 99%

“…Status-Cellular redox status has been shown to affect gene expression under conditions of oxygen deficiency (27)(28)(29)(30). To test whether it played an essential role in IAP-2 induction under hypoxia, we adjusted the redox status of the cells pharmacologically, using two classes of reagents.…”

Section: Hypoxic Expression Of Iap-2 Does Not Depend On Changes Of Cementioning

confidence: 99%

Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia

Dong

Venkatachalam

Wang

et al. 2001

Journal of Biological Chemistry

141

121

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Hypoxia is a key determinant of tissue pathology during tumor development and organ ischemia. However, little is known regarding hypoxic regulation of genes that are directly involved in cell death or death resistance. Here we report the striking induction by severe hypoxia of the anti-apoptotic protein IAP-2. Hypoxic cells with IAP-2 up-regulation became resistant to apoptosis. IAP-2 was induced by hypoxia per se rather than by the secondary effects of hypoxia, including ATP depletion and cell injury. The inductive response did not relate to alterations of cellular redox status or arrest of mitochondrial respiration. On the other hand, IAP-2 induction was attenuated by actinomycin D, suggesting a role for gene transcription. In vitro nuclear run-on assays demonstrated specific increases in IAP-2 transcriptional activity after hypoxia exposure. HIF-1, the primary transcription factor that is responsible for multiple gene activation under hypoxia, does not have a role in IAP-2 expression. HIF-1 and IAP-2 were induced by different degrees of hypoxia; severe hypoxia or anoxia was required for IAP-2 induction. Moreover, cobalt chloride and desferrioxamine activated HIF-1 but not IAP-2. Finally, IAP-2 was induced by severe hypoxia in mouse embryonic stem cells that were deficient of HIF-1. Thus, this study not only provides the first demonstration of hypoxic regulation of an anti-apoptotic gene but also suggests the participation of novel hypoxia-responsive transcription mechanisms.

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Cytochromes and oxygen radicals as putative members of the oxygen sensing pathway

Cited by 48 publications

References 27 publications

Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity

Effect of N-acetyl-cysteine on the hypoxic ventilatory response and erythropoietin production: linkage between plasma thiol redox state and O2 chemosensitivity

Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia

Up-regulation of Apoptosis Inhibitory Protein IAP-2 by Hypoxia

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