2011
DOI: 10.1016/j.bbapap.2010.06.022
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Cytochromes P450 are essential players in the vitamin D signaling system

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Cited by 243 publications
(241 citation statements)
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“…Firstly, in the liver to form 25OHD the main circulating form of vitamin D. The predominant enzyme involved in this 25-hydroxylation reaction has yet to be definitively identified but is likely to be the cytochrome P450, CYP2R1 (11) . Activation of 25OHD to the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH) 2 D) is then catalysed by the enzyme 25OHD-1a-hydroxylase (CYP27B1), which is located primarily in the proximal tubules of the kidney (11,12) . In classical vitamin D physiology, the 1,25(OH) 2 D produced by the kidneys acts in an endocrine fashion to help regulate mineral homoeostasis and bone metabolism (Fig.…”
Section: Vitamin D Physiology: Classical and Non-classical Actionsmentioning
confidence: 99%
“…Firstly, in the liver to form 25OHD the main circulating form of vitamin D. The predominant enzyme involved in this 25-hydroxylation reaction has yet to be definitively identified but is likely to be the cytochrome P450, CYP2R1 (11) . Activation of 25OHD to the hormonal form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH) 2 D) is then catalysed by the enzyme 25OHD-1a-hydroxylase (CYP27B1), which is located primarily in the proximal tubules of the kidney (11,12) . In classical vitamin D physiology, the 1,25(OH) 2 D produced by the kidneys acts in an endocrine fashion to help regulate mineral homoeostasis and bone metabolism (Fig.…”
Section: Vitamin D Physiology: Classical and Non-classical Actionsmentioning
confidence: 99%
“…Although the vitamin D receptor (VDR) (also an NR) itself was not differentially expressed, there was an overrepresentation of VDR target genes among the genes with increased expression in synovial tissues from arthritisprotected rats, suggesting increased VDR activity. Furthermore, genes implicated in the hydroxylation and synthesis of alternative vitamin D active metabolites such as Cyp27a1, Cyp2j3 and Cyp11a1 (6,7) were also expressed in increased levels in the tissues of the protected rats, suggesting that the increased expression of target genes could be related at least in part to increased local production of VDR agonists (5).…”
Section: Introductionmentioning
confidence: 99%
“…(27) . Several enzymes can accomplish this first hydroxylation of 25(OH)D, but CYP2R1 seems to be the key one (28,29) . Interestingly, Cyp2r1…”
Section: Uptake Of Vitamin Dmentioning
confidence: 99%