Cytocompatibility and mechanical properties of novel porous 316L stainless steel

Kato, Komei; Yamamoto, Akiko; Ochiai, Shojiro; Wada, Masahiro; Daigo, Yuzo; Kita, Koichi; Omori, Kenichi

doi:10.1016/j.msec.2013.02.038

Cited by 38 publications

(19 citation statements)

References 39 publications

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“…Nevertheless, the samples density increased while porosity decreased when the SS316L composition was increased from 50 wt.% to 60 wt.%, which was agreed with the result found by the previous researcher [13]. The density of the samples with 50 wt% and 60 wt.% SS316L are 0.43 g/cm 3 and 0.60 g/cm 3 respectively. While the porosity percentage for the sample with 50 wt.% and 60 wt.%…”

Section: (B) (A)supporting

confidence: 91%

“…The slurry should not become neither too thick nor too thin. The density of the samples is in the range of 0.43 g/cm 3 to 0.60 g/cm 3 . The porosity percentage of the samples was found the range of 89.2% to 93.6%.…”

Section: Discussionmentioning

confidence: 99%

“…Amongst all, stainless steel 316L is the longest being applied in the biomedical implant which is since 1920's [1,2]. Stainless steel 316L are low cost, easy availability and processing, good workability, high fatigue life and fracture toughness [1,3,4]. However, the modulus of elasticity of stainless steel 316L is much higher compared to natural bone which is 193 GPa for stainless steel 316L and 0.1-20 GPa for natural bone.…”

Section: Introductionmentioning

confidence: 99%

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Fabrication of Porous Stainless Steel 316L for Biomedical Applications

2017

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Abstract. Porous metals are very attractive materials for biomedical application as the physical and mechanical properties of these materials can be tailored similarly to the natural bone. In this work, porous stainless steel 316L has been fabricated by foam replication method. This method offers a lot of advantages including of easy processing technique, very economic, does not involve the use of toxic chemical and capable of producing porous structure that almost similar to natural bone. The porous stainless steel 316L (SS316L) samples were prepared by varying the SS316L composition from 40 wt% to 60 wt%. Sintering process was carried out at 1250C in a vacuum furnace. The microstructure and pore size were observed and determined through Scanning Electron Microscope (SEM). Archimedes method was used to measure the samples density, while compression test was carried out to determine the compressive strength and elastic modulus. The average pore size for samples with 50 wt% and 60 wt% SS316L are 268µm and 299µm respectively. Samples with 40 wt% SS316L experienced the largest shrinkage which is 33% while the sample with 60 wt% SS316L experienced the smallest shrinkage which is 21%. The density and porosity of the porous SS316L with 50 wt% SS316L are 0.43g/cm3 and 93.6% respectively, and for porous SS316L with 60 wt% SS316L are 0.69 g/cm3 and 89.2% respectively. The modulus of elasticity and compressive strength for porous SS316L with 60 wt% SS316L are 0.46 GPa and 56 MPa respectively. All these properties are in the range of the natural bone properties. Besides, the cytotoxicity test showed that this porous SS316L does not have a cytotoxic potential for biomedical implant.

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Section: (B) (A)supporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Fabrication of Porous Stainless Steel 316L for Biomedical Applications

2017

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“…For porous bone substitutes, the optimal pore size for the attachment, differentiation, and growth of osteoblasts and vascularization has been found to range between 100 and 500 m [3]. Although metals like stainless steel, titanium, and titanium alloys are widely used in orthopaedic surgery because of their excellent mechanical properties [2][3][4], they, being nondegradable, remain in the body after tissue regeneration. Now, the presence of permanent implants or, to be more precise, the release of their metal ions can in the long run negatively affect the organism.…”

Section: Introductionmentioning

confidence: 99%

Fe and Fe-P Foam for Biodegradable Bone Replacement Material: Morphology, Corrosion Behaviour, and Mechanical Properties

Hrubovčáková

Kupková

Džupon

2016

Advances in Materials Science and Engineering

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Iron and iron-phosphorus open-cell foams were manufactured by a replica method based on a powder metallurgical approach to serve as a temporary biodegradable bone replacement material. Iron foams alloyed with phosphorus were prepared with the aim of enhancing the mechanical properties and manipulating the corrosion rate. Two different types of Fe-P foams containing 0.5 wt.% of P were prepared: Fe-P(I) foams from a phosphated carbonyl iron powder and Fe-P(II) foams from a mixture of carbonyl iron and commercial Fe3P. The microstructure of foams was analyzed using scanning electron microscopy. The mechanical properties and the corrosion behaviour were studied by compression tests and potentiodynamic polarization in Hank’s solution and a physiological saline solution. The results showed that the manufactured foams exhibited an open, interconnected, microstructure similar to that of a cancellous bone. The presence of phosphorus improved the mechanical properties of the foams and decreased the corrosion rate as compared to pure iron foams.

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“…Currently its most important applications are in manufacturing implants, such as femoral heads, hip stems, and bone screws3637. Such implants are significantly less expensive than those made of ceramics, polymers, composites, and alloys323839.…”

mentioning

confidence: 99%

Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications

Finšgar

Uzunalić

Stergar

et al. 2016

Sci Rep

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Corrosion resistance, biocompatibility, improved osteointegration, as well the prevention of inflammation and pain are the most desired characteristics of hip replacement implants. In this study we introduce a novel multi-layered coating on AISI 316LVM stainless steel that shows promise with regard to all mentioned characteristics. The coating is prepared from alternating layers of the biocompatible polysaccharide chitosan and the non-steroid anti-inflammatory drug (NSAID), diclofenac. Electrochemical methods were employed to characterize the corrosion behavior of coated and uncoated samples in physiological solution. It is shown that these coatings improve corrosion resistance. It was also found that these coatings release the incorporated drug in controlled, multi-mechanism manner. Adding additional layers on top of the as-prepared samples, has potential for further tailoring of the release profile and increasing the drug dose. Biocompatibility was proven on human-derived osteoblasts in several experiments. Only viable cells were found on the sample surface after incubation of the samples with the same cell line. This novel coating could prove important for prolongation of the application potential of steel-based hip replacements, which are these days often replaced by more expensive ceramic or other metal alloys.

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Cytocompatibility and mechanical properties of novel porous 316L stainless steel

Cited by 38 publications

References 39 publications

Fabrication of Porous Stainless Steel 316L for Biomedical Applications

Fabrication of Porous Stainless Steel 316L for Biomedical Applications

Fe and Fe-P Foam for Biodegradable Bone Replacement Material: Morphology, Corrosion Behaviour, and Mechanical Properties

Novel chitosan/diclofenac coatings on medical grade stainless steel for hip replacement applications

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