Cytocompatibility, interactions, and uptake of polyethyleneimine‐coated boron nitride nanotubes by living cells: Confirmation of their potential for biomedical applications

Ciofani, Gianni; Raffa, Vittoria; Menciassi, Arianna; Cuschieri, Alfred

doi:10.1002/bit.21952

Cited by 222 publications

(176 citation statements)

References 35 publications

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“…Research results show that poly ethylene imine modified BNNTs does not produce great influence [9] on neuroblastoma survival, metabolism and cell regeneration. Their subsequent studies showed that the BNNTs modified by poly lysine had good cell compatibility with glioblastoma and fibroblast cells.…”

Section: Introductionmentioning

confidence: 99%

Review On The Application Of Boron Nitride Nanotubes

Wang¹,

Chen²,

Li³

2016

Proceedings of the 2016 5th International Conference on Environment, Materials, Chemistry and Power Electronics

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Abstract. Boron nitride nanotubes (BNNTs) is a kind of material which have similar structure with carbon nanotubes (CNTs), but have more excellent performance, through experiments and research, scientists have a more thorough understanding of the preparation methods and properties of BNNTs, at the same time, they also explored the application value of BNNTs. This article summarized and introduced the application of BNNTs from the composite additives, hydrogen storage materials, biomedical materials and environmental purification material, and prospected the future development of BNNTs..

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Section: Introductionmentioning

confidence: 99%

Review On The Application Of Boron Nitride Nanotubes

Wang¹,

Chen²,

Li³

2016

Proceedings of the 2016 5th International Conference on Environment, Materials, Chemistry and Power Electronics

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“…Moreover, Ciofani et al [7,8] conducted a wide study of the biocompatibility of nanotubes of boron nitride (BNNTs) and their biomedical applications, and the Golberg and Bando group recently reported the transport of a drug that helps decrease cancer using nanosheets of BN with high solubility in water [9]. From the physical-chemical point of view, nanosheets of boron nitride with hexagonal symmetry (hBNNs) are comprised of one mesh of atoms of B and N ordered and alternated in a hexagonal array similar to graphene with sp 2 hybridization; from its gap value of 5.92 eV, hBNN is classified as a semiconductor [10].…”

Section: Introductionmentioning

confidence: 99%

Non-covalent functionalization of hexagonal boron nitride nanosheets with guanine

et al. 2015

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Density functional theory (DFT) calculations were performed to analyze changes in the structural and electronic properties generated by the interaction of a single nucleobase group (guanine) with the surface of boron nitride nanosheets with hexagonal symmetry (hBNNs). Nanosheets in two contexts were tested: pristine sheets and with point defects (doped with carbon atoms). The criterion of energy minimum was used to find the ground state of the nine possible isomers generated by the hBNNs-guanine interaction. The phenomenon of physisorption is known to occur at values less than 1.0 eV; the adsorption energy results revealed that the preferential geometry was a parallel arrangement between the two partners, with van der Waals-type bonds generated for the hBNNs doped with two carbon atoms. This was the only energetically stable configuration, thus revealing a vibrational mode rather than imaginaries. Furthermore, the hBNNs/C-guanine system has a low value for work function, and therefore could be used in health applications such drug transport and delivery. The increased polarity values suggest that these nanosheets could be solubilized in common solvents used in experimental processes.

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“…[13][14][15][16] Therefore, it is considered promising for biomedical applications, such as drug delivery. [17][18][19][20][21][22][23] Recently, applications of BN nanospheres (BNNS) as carriers for DNA or chemotherapy drugs have only begun to emerge. [24][25][26][27][28] Moreover, BNNS are composed of a substantial number of boron atoms, which can serve as boron carriers…”

Section: Introductionmentioning

confidence: 99%

pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery

Feng

Zhang²,

Chen³

et al. 2018

IJN

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Background Anticancer drug-delivery systems (DDSs) capable of responding to the physiological stimuli and efficiently releasing drugs inside tumor cells are highly desirable for effective cancer therapy. Herein, pH-responsive, charge-reversal poly(allylamine hydrochlorid)−citraconic anhydride (PAH-cit) functionalized boron nitride nanospheres (BNNS) were fabricated and used as a carrier for the delivery and controlled release of doxorubicin (DOX) into cancer cells. Methods BNNS was synthesized through a chemical vapor deposition method and then functionalized with synthesized charge-reversal PAH-cit polymer. DOX@PAH-cit–BNNS complexes were prepared via step-by-step electrostatic interactions and were fully characterized. The cellular uptake of DOX@PAH-cit–BNNS complexes and DOX release inside cancer cells were visualized by confocal laser scanning microscopy. The in vitro anticancer activity of DOX@ PAH-cit–BNNS was examined using CCK-8 and live/dead viability/cytotoxicity assay. Results The PAH-cit–BNNS complexes were nontoxic to normal and cancer cells up to a concentration of 100 µg/mL. DOX was loaded on PAH-cit–BNNS complexes with high efficiency. In a neutral environment, the DOX@PAH-cit–BNNS was stable, whereas the loaded DOX was effectively released from these complexes at low pH condition due to amide hydrolysis of PAH-cit. Enhanced cellular uptake of DOX@PAH-cit–BNNS complexes and DOX release in the nucleus of cancer cells were revealed by confocal microscopy. Additionally, the effective delivery and release of DOX into the nucleus of cancer cells led to high therapeutic efficiency. Conclusion Our findings indicated that the newly developed PAH-cit–BNNS complexes are promising as an efficient pH-responsive DDS for cancer therapy.

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Cytocompatibility, interactions, and uptake of polyethyleneimine‐coated boron nitride nanotubes by living cells: Confirmation of their potential for biomedical applications

Cited by 222 publications

References 35 publications

Review On The Application Of Boron Nitride Nanotubes

Review On The Application Of Boron Nitride Nanotubes

Non-covalent functionalization of hexagonal boron nitride nanosheets with guanine

pH-responsive charge-reversal polymer-functionalized boron nitride nanospheres for intracellular doxorubicin delivery

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