Cytocompatibility of Medical Biomaterials Containing Nickel by Osteoblasts: a Systematic Literature Review

Mikulewicz, Marcin; Chojnacka, Katarzyna

doi:10.1007/s12011-010-8798-7

Cited by 34 publications

(16 citation statements)

References 71 publications

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“…Fors et al 7) reported that there were high levels of metals bioaccumulated in the dental plaques. The bacterial biological biofilm could induce a vasodilatation of the gingival vasculature and accelerate the gingival blood flow, which thus may facilitate the absorption of metals into the bloodstream 3,26) .…”

Section: Discussionmentioning

confidence: 99%

“…However, the orthodontic devices would permanently interact with the chemical and physical stimulations of oral physiological environment, such as variable pH values, dietary intake, temperature, dental plaque, mechanical fatigue and so on [1][2][3][4][5][6][7][8][9][10] , thus a question arises about potential biosafety considerations for such a therapy.…”

Section: Introductionmentioning

confidence: 99%

“…Cytotoxicity assays in vitro media further revealed that the nickel ions released had potential cytotoxic and genotoxic effects on cells, which may concentrations 3,6,7,11,[22][23][24][25][26] .…”

Section: Introductionmentioning

confidence: 99%

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Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Guo

Liu

Zheng

et al. 2014

J. Hard Tissue Biology.

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Biocompatibility and resistance to biodeterioration of materials has been studied using various approaches, including the analysis of various markers of exposure, both in vitro and in vivo. The possible release of trace elements during orthodontic treatment and their potential toxicity to patients have been an increasing concern. The wide range of appliances routinely used during orthodontic treatment is typically made of alloys which may contain cobalt, chromium, iron, nickel, and titanium, of which the major concern is nickel. Nickel concentrations in humans undergoing orthodontic treatment have been assessed in many investigations, although few have specifically examined urine specimens. Urinary nickel concentrations can reflect systemic levels in whole organisms, and as a non-invasive means of study, urine analysis can easily achieve the compliance of participants and guardians. In addition, the predominant metabolic route of nickel is through the kidneys. Therefore, urinary samples are seen as a good indicator for monitoring trace metals released from orthodontic appliances. According to the literature, metal ions are released only in the initial stage of the treatment. Thus, the duration of our study was limited to the first 6 months of treatment. Since urinary nickel levels of adolescents in the initial period of fixed orthodontic treatment are being investigated and reported for the first time in this paper, the aim of our study is to quantitatively evaluate urinary nickel levels and further to summarize the dynamic metabolic regularity of systemic nickel for adolescents in the initial period of fixed orthodontic treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Guo

Liu

Zheng

et al. 2014

J. Hard Tissue Biology.

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“…Negative effect of dental alloys in the oral cavity is their capability to produce local or systematic changes that may be short term or long term or systematic. Interactions between the oral environment and dental alloys can also generate some discomforts like metallic taste, discoloration of teeth, galvanic currents, oral lesions, dermatitis hypersensitivity, dental implant rejection, and generating tumors and decay [5][6].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical and corrosion behavior of two chromium dental alloys in artificial bioenvironments

Banu¹,

Juganaru²,

Marcu

2017

MATEC Web Conf.

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Abstract. The purpose of this study is to compare the corrosion and tarnish behavior of NiCrMo and CoCrMo cast dental alloys in artificial bio environments. The cobalt chromium alloys are known and used in dentistry for many years, but its difficult machinability because of the strength and hardness, is an argument for scientists to study alternative materials with comparable biocompatibility. On the other hand, for dentistry devices beside corrosion behavior is important the aesthetic so, the used alloys have to preserve their shining and do not stain. The corrosion resistance has been evaluated using the Atomic mass spectroscopy method for ion release determination, the anodic polarization curves and the open circuit potential -time monitoring for corrosion behavior evaluation and optical microscopy for the structure analysis. The tarnish tendency of alloys was estimated using the method of cyclic immersion with frequency of 10 seconds for each minute during 72 hours in Na2S containing solution. The most important conclusion is that the alloys are comparable from corrosion and tarnish point of view, but we recommend to use the nickel base alloy only for orthodontic devices implanted for short periods of time, because of higher quantity of released ions.

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“…The potential release of harmful V and Al ions from Ti alloys used for biomedical applications has been reported and research has attempted to overcome their long-term health risks [13,14]. In regards to the biocompatibility of NiTi alloys for use in medical applications, the hypersensitivity caused by the release of Ni remains a concern [301][302][303].…”

Section: Introductionmentioning

confidence: 99%

Mechanical and microstructural characterisation in the processing of biomedical metallic fine tubes

Yao-wu¹

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Fine tube stents are used for maintaining localised flow in stenotic blood vessels. Elasticity and plasticity for expansion, rigidity for resisting bending under force and strength to prevent unexpected failure, are required properties of the tubes from which these stents are formed. Biomedical metastable β titanium alloys have been developed as implant materials for a large number of biomedical applications due to a combination of favourable characteristics, e.g. good biocompatibility, excellent toughness and corrosion resistance. A metastable β alloy, Ti-25Nb-3Mo-3Zr-2Sn, has been developed without toxic alloying elements, which is a promising candidate material for stent applications. Metallic materials used for stents are commonly not biodegradable and implanted in the vessel permanently, which may provoke in-stent restenosis and stent thrombosis. In order to remove the implanted materials after service, biodegradable materials, absorbed by the body slowly, are also a field of research interest. Magnesium alloys have been used in studies for biomedical stent applications as a new biodegradable material. Magnesium stents can reopen the blocked blood vessels temporarily before degrading in physiological environments. In addition to the biodegradable characteristics, their mechanical properties are reasonable. The Mg-3Al-1Zn (AZ31) alloy is the subject of some research on the processing of biomedical magnesium alloys as it is a commonly available commercial alloy. Consequently, the Ti-25Nb-3Mo-3Zr-2Sn alloy and the AZ31 magnesium alloy have been used in this thesis to investigate the evolution of mechanical properties and microstructure in the processing of fine tubes.The deformation mechanisms during cold deformation of metastable β titanium alloys are mainly associated with martensitic phase transformations and mechanical twinning. It has been reported that stress-induced phase transformations and {112}〈111〉, {332}〈113〉 twinning modes may be activated under different stress states in metastable β titanium alloys. They can exhibit varying elasticity, Young's modulus and strain hardening behaviour. Because the martensitic start temperature is below room temperature for most metastable β titanium alloys, the α″ martensitic transformation can easily occur under a small amount of external stress. Mechanical twins were reported to hinder slip and dislocation motion thereby increasing the strain hardening rate. The development of β and α″ texture during processing is another critical influence on the mechanical properties of fine tubes. Therefore, studies on the martensitic transformation, mechanical twins and texture evolution is of significance in order to understand the processing of β titanium fine tubes.ii Magnesium alloys deform through the formation of a large amount of mechanical twins due to the relatively low critical stress to activate twinning in comparison with 〈 + 〉 slip. There are typically two primary mechanical twinning modes for magnesium alloys, {101 ̅ 2} extension twins and {101 ̅ 1} cont...

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Cytocompatibility of Medical Biomaterials Containing Nickel by Osteoblasts: a Systematic Literature Review

Cited by 34 publications

References 71 publications

Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Urinary Nickel Ion Evaluation of Adolescents during the Initial Period of Orthodontic Fixed Treatment

Electrochemical and corrosion behavior of two chromium dental alloys in artificial bioenvironments

Mechanical and microstructural characterisation in the processing of biomedical metallic fine tubes

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