Cytocompatibility of Ti–xZr alloys as dental implant materials

Ou, Pinghua; Hao, Cong; Liu, Jue; He, Rengui; Wang, Baoqi; Ruan, Jianming

doi:10.1007/s10856-021-06522-w

Cited by 22 publications

(17 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, a novel dental implant material, the Ti-45Zr alloy which has good biomechanical properties and excellent cytocompatibility [2], was studied in animal implantation experiments. Toxic and side effects, immune responses, and bone integration were systematically studied to provide the theoretical basis for Ti-45Zr alloy clinical application.…”

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Bone Response in vivo of Ti-45Zr Alloy as Dental Implant Material

Wang

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

BackgroundTi-Zr alloys have gain more attention as a new metallic biomaterial. using as implants both for orthopedics and dentistry. More recently, our group found promising results for Ti-45Zr alloy, while presenting a low elastic modulusand, a pronounced excellent mechanic character and excellent cell compatibility in vitro. However, the biocompatibility and the potential to promote osteogenesis remains unclear.Methods In this study, the biocompatibility, osteointegration ability, and immune response effects of Ti-45Zr alloy were systematicly investigated in vivo. The biocompatibility of Ti-45Zr alloy was evaluated by hemolysis test and in vivo implantation test in New Zealand white rabbits. The bone integration ability of Ti-45Zr alloy with tissue interface was also investigated by hard tissue section staining and biomechanical experiments. At the same time, the effects of Ti-45Zr alloy on the immune response of Sprague Dawley rats were studied through serum biochemical detection and immunohistochemistry (IHC) staining of hard tissue sections. Interleukin-6 (IL-6) and Interleukin-10 (IL-10) was detected by ELISA. ResultsResults showed that the alloy had good blood compatibility and no body side effects. After implantation in vivo, The serum concentrations of anti-inflammatory and proinflammatory factors reached the highest values at the 9th day, and the inflammation level around the implant hole returned well with the prolongation of the implantation time. On the 14th day, new bone formation was observed around the three materials. The Ti-45Zr alloy was conducive to the polarisation balance of the macrophages.ConclusionThe Ti-45Zr alloy showed exccelent biocompatibility and good osteointegration ability, and it is beneficial to the polarization balance of macrophages.It confirmed that the Ti-45Zr alloy can be used as a dental implant material.

show abstract

Section: Introductionmentioning

confidence: 99%

WITHDRAWN: Bone Response in vivo of Ti-45Zr Alloy as Dental Implant Material

Wang

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…121,122 In a recent study, titanium alloyed with zirconium (Zr) has shown excellent biocompatibility and osteoconductive activity compared to pure titanium. 123 TI-6Al-4V in an untreated and bulk state has been shown to be biocompatible with fibroblasts. However, TI-6Al-4V may release vanadium and aluminum ions, which may be cytotoxic compared to pure titanium.…”

Section: Wettabilitymentioning

confidence: 99%

“…This was further corroborated by reactive oxygen species (ROS) tests and inflammatory responses where the alloy significantly increased ROS generation in HGF and facilitated the up-regulation of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8). Titanium, however, has been generally shown to be cytocompatible due to its inertness and superior corrosion resistance. , In a recent study, titanium alloyed with zirconium (Zr) has shown excellent biocompatibility and osteoconductive activity compared to pure titanium . TI-6Al-4V in an untreated and bulk state has been shown to be biocompatible with fibroblasts.…”

Section: Implant Characteristicsmentioning

confidence: 99%

Preventing Peri-implantitis: The Quest for a Next Generation of Titanium Dental Implants

Hasan

Bright

Hayles

et al. 2022

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Titanium and its alloys are frequently the biomaterial of choice for dental implant applications. Although titanium dental implants have been utilized for decades, there are yet unresolved issues pertaining to implant failure. Dental implant failure can arise either through wear and fatigue of the implant itself or peri-implant disease and subsequent host inflammation. In the present report, we provide a comprehensive review of titanium and its alloys in the context of dental implant material, and how surface properties influence the rate of bacterial colonization and peri-implant disease. Details are provided on the various periodontal pathogens implicated in peri-implantitis, their adhesive behavior, and how this relationship is governed by the implant surface properties. Issues of osteointegration and immunomodulation are also discussed in relation to titanium dental implants. Some impediments in the commercial translation for a novel titanium-based dental implant from “bench to bedside” are discussed. Numerous in vitro studies on novel materials, processing techniques, and methodologies performed on dental implants have been highlighted. The present report review that comprehensively compares the in vitro, in vivo, and clinical studies of titanium and its alloys for dental implants.

show abstract

“…The hardness of the Ti-Zr alloys increased with increasing Zr content and ranged from 266 HV (Ti-10Zr) to 350 HV (Ti-40Zr) (Ho et al, 2008). Ti-45Zr has the optimum strength/elastic modulus ratio and osteogenic activity, which would be advantageous for reducing the fracture risk of implant materials (Ou et al, 2021). Due to these properties, Ti-Zr alloys are suitable for making narrow dental implants (NDIs), which are an alternative treatment when there is insufficient bone for regular implants (Gonzalez-Valls et al, 2021).…”

Section: Ti-zr-cu Alloysmentioning

confidence: 99%

Biological properties of Cu-bearing and Ag-bearing titanium-based alloys and their surface modifications: A review of antibacterial aspect

Yan

et al. 2022

Front. Mater.

View full text Add to dashboard Cite

The use of titanium dental implants to replace missing teeth represents an important field of daily dental practice worldwide, which is highly reliable for long-term survival and success rates. However, titanium dental implants still have intrinsic problems that cannot meet the clinical requirements. Improving the performance of implants is an increasingly important area of dental research to reduce infection rates. Improved properties can be achieved by two main methods: 1) the overall change in the materials by changing the elemental composition and 2) surface modifications. This review provides an overview of various titanium-based alloys that have been employed to achieve a higher survival rate of implantation by adding elements or modifying the surface, with a special focus on their antibacterial applications. Recent developments in titanium-based alloys containing various antibacterial agents have been described in detail, including Cu-bearing, Ag-bearing, and Zr-bearing Ti alloys. Moreover, the applications of bioactive coatings and 3D printing materials with antibacterial properties are reviewed. This review aims to highlight the antibacterial challenges associated with titanium-based alloys to promote the further development and clinical application of antibacterial alloys.

show abstract

Cytocompatibility of Ti–xZr alloys as dental implant materials

Cited by 22 publications

References 48 publications

WITHDRAWN: Bone Response in vivo of Ti-45Zr Alloy as Dental Implant Material

WITHDRAWN: Bone Response in vivo of Ti-45Zr Alloy as Dental Implant Material

Preventing Peri-implantitis: The Quest for a Next Generation of Titanium Dental Implants

Biological properties of Cu-bearing and Ag-bearing titanium-based alloys and their surface modifications: A review of antibacterial aspect

Contact Info

Product

Resources

About