Cytodiagnosis of congenital mesoblastic nephroma: A case report

Abstract

Mesoblastic nephroma (MN) is the most common renal tumor diagnosed in infancy. A case of congenital MN was diagnosed in a 6-month old child by fine-needle aspiration cytology. The smears were cellular and consisted of plump spindle cells arranged in clusters along with scattered naked nuclei in the background. Blastemal, epithelial, or glomeruloid structures were not seen. Considering the age and the cytomorphology, a diagnosis of cellular variant of MN was offered which was confirmed on histopathology. Unlike Wilms tumor, preoperative chemotherapy is not required for MN. Hence cytologic diagnosis is important.

Cytological diagnosis of mesoblastic nephroma: A report of three cases with summary of prior published cases

“…Accurate preoperative cytological diagnosis of CMN is important to avoid chemotherapy in neonates and infants. Newborn/female 11 3 9 3 8 cm Mesenchymal neoplasia Cellular CMN Gupta et al 8 1 year/female 14.5 3 10.5 3 8.5 cm CMN Cellular CMN Kulkarni et al 9 6 month/female 9 3 5 3 4.…”

“…3 There are only a handful of case reports available subsequently which describe the FNAC findings of CMN. A summary of prior published cases are given in Table I [3][4][5][6][7][8][9] . Most of the typical CMN cases being cohesive, show low cellularity on aspirates.…”

An Approach to Renal Masses in Pediatrics

“…7,104 Based on histopathologic appearances, congenital mesoblastic nephroma is subtyped into classic (24%), cellular (66%), and mixed (10%) types. 103,105,[107][108][109] The classic form is morphologically identical to infantile fibromatosis of the renal sinus 109 with fusiform…”