Cytodiagnosis of unusual metastases in parotid gland

Thomas, Shannon D.; Bhake, Arvind

doi:10.4103/jomfp.jomfp_267_20

Cited by 3 publications

(1 citation statement)

References 14 publications

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“…Head and neck tumors make up two-thirds of the metastases, while infraclavicular primary tumors are less likely to spread to the parotid. 12 These distant metastases derive from numerous primary sites, including about 30 cases of metastasis from breast carcinomas, [13][14][15][16][17][18][19][20] and are thought to reach the parotid through the thoracic duct or paraspinal venous plexus. 18 The other major salivary glands -submandibular and sublingual glands -are much less frequently affected by secondary tumors.…”

Section: Discussionmentioning

confidence: 99%

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Almeida¹,

Salgado²,

Ferraz³

et al. 2023

j.rpemd

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Metastatic spread to the salivary glands is rare, occurring primarily from head and neck tumors to the parotid gland. So far, only one sublingual gland metastasis has been reported in the literature. We herein report the second case of metastasis to this gland occurring in a woman in her 50s, previously diagnosed with HER2-positive metaplastic breast carcinoma (MpBC) with chondroid differentiation, with lymph node and diffuse organ metastases. The sublingual lesion presented as a tumefaction on the floor of the mouth, causing masticatory discomfort. Histologically it was formed by epithelial cells with high-grade cytomorphological features with a large central area of chondroid differentiation. The case was clinically and pathologically challenging, given the rarity of the primary MpBC and the improbable secondary location. Alternative primary salivary gland tumors with chondroid differentiation were considered, but ultimately the clinical integration was crucial in establishing the diagnosis of MpBC metastasis to the sublingual gland.

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Section: Discussionmentioning

confidence: 99%

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Almeida¹,

Salgado²,

Ferraz³

et al. 2023

j.rpemd

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Malignant melanoma diagnosed by fine‐needle aspiration in cases presenting with parotid mass

Turcan,

Yilmaz,

Acu

et al. 2024

Cytopathology

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BackgroundOne of the most common malignancies that metastasize to the parotid glands and associated lymph nodes is cutaneous melanoma. Although fine‐needle aspiration (FNA) is well established for diagnosing primary salivary gland tumours, there is limited literature on its role in diagnosing metastatic lesions.Aims and ObjectivesThis study aims to investigate the cytomorphological features of malignant melanoma diagnosed by FNA in cases presenting with a parotid mass.Materials and MethodsWe present the clinical and cytomorphological findings of four cases. Conventional FNA biopsy smears and cell blocks were performed using standard techniques and for the differential diagnosis, a panel of immunohistochemical markers was used.ResultsThe patients included three females and one male, aged 54 to 77. FNA biopsies revealed atypical cells with large, hyperchromatic, pleomorphic nuclei, some of which exhibited prominent nucleoli. Plasmacytoid and oncocytic morphologies were also observed. Numerous mitotic figures were noted. Immunohistochemical staining showed HMB‐45, S100 positivity in all cases. SOX10, MART‐1 and MITF positivity were also observed. Three of the four patients had no history or suspected lesions of melanoma at the time of FNA diagnosis. The absence of melanin pigment complicated the diagnosis, but immunostains confirmed malignant melanoma.ConclusionDiagnosing malignant melanoma by FNA can be challenging, especially when the melanoma is in an unusual site, cytological findings are ambiguous, and there is no history of cutaneous melanoma. Accurate diagnosis requires a high level of suspicion and the use of appropriate immunohistochemistry.

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Lung cancer metastasizing to salivary glands: Systematic review

Gupta,

Brar,

Shubha

et al. 2023

Journal of Cancer Research and Therapeutics

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S Metastasis to salivary glands from the secondary source outside the head and neck region is extremely rare and Carcinoma Lung is one of the rarest sources of distant spread to salivary glands. Owing to missed diagnosis and misdiagnosis, accurate identification of clinical and pathological aspects of these metastatic lesions remains a challenging task. Many studies regarding metastasis to the oral cavity have been already documented in the literature, but very little research work has been done to analyse the cases of lung cancer metastasis as the sole primary source, particularly to salivary glands. Thus this review was conducted to analyse the published cases of lung cancer metastasizing to salivary glands as the only primary source till date. An electronic search of the published literature was performed without publication year limitation in PubMed/ Medline, Scopus, Google Scholar, Web of Science, Science direct, Embase, and Research gate databases, using Mesh keywords like (Lung cancer’, OR ‘Lung carcinoma), AND (Metastasis OR Metastases), And (Salivary glands OR Parotid gland OR Submandibular gland OR Sublingual gland). We also searched all related journals manually. The reference list of all articles was also checked. Our research revealed 34 relevant papers between 1965-2022 with a total of 44 patients. The most prevalent diagnosed metastatic Lung cancer was Small cell lung cancer. Parotid was the most common gland involved in metastasis. 48% of patients died of metastasis with a mean survival time of 2.2 years. Salivary gland metastasis from Lung cancer is very rare and has a poor prognosis. More cases need to be published in order to raise awareness of these lesions and gain a better understanding of their characteristics.

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Cytodiagnosis of unusual metastases in parotid gland

Cited by 3 publications

References 14 publications

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Metastasis to the sublingual gland of metaplastic breast carcinoma – a case report

Malignant melanoma diagnosed by fine‐needle aspiration in cases presenting with parotid mass

Lung cancer metastasizing to salivary glands: Systematic review

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