Cytogenetic analysis of an exposed-referent study: perchloroethylene-exposed dry cleaners compared to unexposed laundry workers

Tucker, James D.; Sorensen, Karen; Ruder, Avima M.; McKernan, Lauralynn Taylor; Forrester, Christy; Butler, Mary Ann

doi:10.1186/1476-069x-10-16

Cited by 17 publications

(9 citation statements)

References 27 publications

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“…4 However, another study found no significant difference in chromosome translocation frequencies between the PERC-exposed dry cleaners and the laundry workers. 5…”

Section: Introductionmentioning

confidence: 99%

Primary DNA Damage in Dry Cleaners with Perchlorethylene Exposure

Azimi

Bahrami

Hachesu

et al. 2017

Int J Occup Environ Med

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“…4 However, another study found no significant difference in chromosome translocation frequencies between the PERC-exposed dry cleaners and the laundry workers. 5…”

Section: Introductionmentioning

confidence: 99%

Primary DNA Damage in Dry Cleaners with Perchlorethylene Exposure

Azimi

Bahrami

Hachesu

et al. 2017

Int J Occup Environ Med

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“…In a study of 18 dry cleaning workers exposed to tetrachloroethylene at TWA concentrations >3.8 ppm for at least 1 year, no significant effect on the frequency of chromosome translocations in peripheral blood lymphocytes was observed in comparison to 18 control laundry workers (Tucker et al 2011).…”

Section: Genotoxicitymentioning

confidence: 94%

Physicochemical properties

Brooke¹

2014

Essentials of Environmental Public Health Science

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Managing Hazardous Materials Incidents is a three-volume set of recommendations for on-scene (prehospital) and hospital medical management of patients exposed during a hazardous materials incident (see https://www.atsdr.cdc.gov/MHMI/index.asp). Volumes I and II are planning guides to assist first responders and hospital emergency department personnel in planning for incidents that involve hazardous materials. Volume III-Medical Management Guidelines for Acute Chemical Exposures-is a guide for health care professionals treating patients exposed to hazardous materials.Fact Sheets (ToxFAQs™) provide answers to frequently asked questions about toxic substances (see https://www.atsdr.cdc.gov/toxfaqs/Index.asp). Other Agencies and OrganizationsThe National Center for Environmental Health (NCEH) focuses on preventing or controlling disease, injury, and disability related to the interactions between people and their environment outside the workplace. Contact: NCEH,

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“…No statistically significant effects of PCE exposure on chromosomal aberrations or sister chromatid exchange were detected in the few relatively small cross-sectional studies evaluated (Ikeda et al, 1980;Seiji et al, 1990;Tucker et al, 2011). Experimental evidence suggests that both mouse and rat liver and kidney are sensitive to the binding of [ 14 C] PCE to DNA.…”

Section: Mechanisms Of Toxicitymentioning

confidence: 99%

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

Cichocki

Guyton

Guha

et al. 2016

The Journal of Pharmacology and Experimental Therapeutics

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Trichloroethylene (TCE) and perchloroethylene or tetrachloroethylene (PCE) are high-production volume chemicals with numerous industrial applications. As a consequence of their widespread use, these chemicals are ubiquitous environmental contaminants to which the general population is commonly exposed. It is widely assumed that TCE and PCE are toxicologically similar; both are simple olefins with three (TCE) or four (PCE) chlorines. Nonetheless, despite decades of research on the adverse health effects of TCE or PCE, few studies have directly compared these two toxicants. Although the metabolic pathways are qualitatively similar, quantitative differences in the flux and yield of metabolites exist. Recent human health assessments have uncovered some overlap in target organs that are affected by exposure to TCE or PCE, and divergent speciesand sex-specificity with regard to cancer and noncancer hazards. The objective of this minireview is to highlight key similarities, differences, and data gaps in target organ metabolism and mechanism of toxicity. The main anticipated outcome of this review is to encourage research to 1) directly compare the responses to TCE and PCE using more sensitive biochemical techniques and robust statistical comparisons; 2) more closely examine interindividual variability in the relationship between toxicokinetics and toxicodynamics for TCE and PCE; 3) elucidate the effect of coexposure to these two toxicants; and 4) explore new mechanisms for target organ toxicity associated with TCE and/or PCE exposure.

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Cytogenetic analysis of an exposed-referent study: perchloroethylene-exposed dry cleaners compared to unexposed laundry workers

Cited by 17 publications

References 27 publications

Primary DNA Damage in Dry Cleaners with Perchlorethylene Exposure

Primary DNA Damage in Dry Cleaners with Perchlorethylene Exposure

Physicochemical properties

Target Organ Metabolism, Toxicity, and Mechanisms of Trichloroethylene and Perchloroethylene: Key Similarities, Differences, and Data Gaps

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