Cytogenetic and immunophenotypic evidence of independent clonal origins of concomitant chronic lymphocytic leukaemia and acute myeloid leukaemia

Souza, Maria Helena Ornellas de; Fernandez, Teresa de Souza; Diamond, Hilda Rachel; Maioli, Maria Christina Paixão; Bacha, Paulo Cesar Pitanga; Lucena, Stella Beatriz De

doi:10.1034/j.1600-0609.2001.066004281.x

Cited by 12 publications

(9 citation statements)

References 10 publications

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“…Использование гистологического, иммунофенотипического (ИФТ) и цитогенетического методов исследования позволяет дифференцировать гематологические опухоли. В то же время только цитогенетическая диагностика предоставляет возможность подтверждать независимое происхождение опухолевых клонов [17][18][19][20][21].…”

Section: Introductionunclassified

“…До сегодняшнего дня патогенез синхронно протекающих опухолей до конца не изучен и остается откры тым вопрос об их независимом происхождении. Цитогенетическое исследование позволяет выявлять неродственные клоны с хромосомными нарушениями и подтверждать независимое происхождение 2 опухолевых заболеваний [17][18][19][20][21]. Однако в литературе представлено небольшое количество клинических случаев синхронного течения ХЛЛ и МДС / ОМЛ, в которых выполненное цитогенетическое исследование позволило выявить различные хромосомные нарушения в опухолевых клонах.…”

Section: Introductionunclassified

“…Нами были проанализированы опубликованные в литературе 14 клинических случаев синхронного течения ХЛЛ и МДС / ОМЛ, в 11 из которых представлены результаты цитогенетического исследования [17,19,[24][25][26][27][28][29][30][31][32]. В 3 случаях при СЦИ выявлены различные хромосомные аберрации в 2 опухолевых клонах ХЛЛ и МДС / ОМЛ: в 1 -трисомия 12 и делеция длинного плеча хромосомы 5; в 1 -трисомия 12 в сочетании с делецией del(14)(q21) и трисомия 84; в 1 -комплексные нарушения кариотипа в обоих клонах клеток [17][18][19]. Следует отметить, что в проанализированных работах при СЦИ для стимулирования В-лимфоцитов использовались стандартные В-клеточные и Т-клеточные митогены: LPS, TPA, Pokeweed (PWM) и фитогемагглютинин.…”

Section: Introductionunclassified

“…Использование комбинации зондов позволило подтвердить различие 2 неродственных клонов, выявленных при СЦИ: делеция 5q и частичная трисомия 12 определялись в разных клетках; оба хромосомных нарушения ни в одной клетке не обнаруживались. В мировой литературе представлен только 1 случай выявления ХЛЛ и МДС с трисомией 12 и делецией 5q [19].…”

Section: Introductionunclassified

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Features of cytogenetic diagnosis of simultaneous chronic lymphocytic leukemia and myelodysplastic syndrome: clinical case report

et al. 2019

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In chronic lymphocytic leukemia, the risk of second tumors including hematological malignancies, with which the use of purine nucleosides and alkylating agents in treatment of chronic lymphocytic leukemia is most often associated, is significantly increased. Concurrent detection of this disease and various hematological tumors is a rare occurrence in hematological practice. Use of cytogenetic method or analysis allows to differentiate between 2 tumors and confirm differences in genetic abnormalities in different clones and on different levels of cell differentiation. This article presents a clinical case of simultaneous chronic lymphocytic leukemia and myelodysplastic syndrome with 2 clones with different cytogenetic abnormalities: partial trisomy of chromosome 12 and deletion of the long arm of chromosome 5 formed at different levels of cell differentiation.

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Features of cytogenetic diagnosis of simultaneous chronic lymphocytic leukemia and myelodysplastic syndrome: clinical case report

et al. 2019

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“…Polycythemia vera is a Philadelphia-negative myeloproliferative disease associated with JAK2 mutation characterized by erythrocytosis; patients are treated by phlebotomy and/or cytotoxic drugs (9). Myeloproliferative neoplasms are associated with lymphoproliferative disease following the administration of cytotoxic drugs or exposure to radiation, but are rarely observed prior to therapy (10,11).…”

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confidence: 99%

Coexistence of follicular lymphoma and an unclassifiable myeloproliferative neoplasm in a treatment-naïve patient: A case report

et al. 2015

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Abstract.Myeloproliferative neoplasms are associated with lymphoproliferative diseases following the administration of cytotoxic drugs or exposure to radiation, but are rare prior to therapy. The present study reports the case of a 61-year-old female with a history of transient ischemic attack. The patient, who presented with a palpable mass in the epitrochlear area of the left arm, was simultaneously diagnosed with follicular lymphoma and an unclassifiable myeloproliferative neoplasm. Excisional lymph node biopsy revealed stage I follicular lymphoma (grade 1). Laboratory findings demonstrated leukocytosis, erythrocytosis, thrombocytosis and decreased erythropoietin. Biopsy of the bone marrow revealed hypercellularity, with predominance of erythroid cells, and large polylobated megakaryocytes with increased mitotic figures, but no evidence of lymphomatous infiltration. The janus kinase 2 V617F mutation was also detected in the cells derived from the bone marrow specimen. Following local excision of the lymph node in the left epitrochlear area, radiation was delivered to the involved field, at a dose of 24 Gy in 12 fractions. The patient was started on hydroxyurea (1 g twice per day, orally) 2 weeks subsequent to radiotherapy, and was administered 500 mg twice per day as maintenance therapy. At the six-month follow-up, the white blood cell count, hemoglobin levels and platelet count had reduced, and the patient was in a healthy condition. A computed tomography scan of the neck, chest and abdomen indicated no abnormalities. To the best of our knowledge, the present study is the first case report of follicular lymphoma coexisting with an unclassifiable myeloproliferative neoplasm in a previously healthy patient. Molecular and genetic studies are required to further evaluate this infrequent disease association.

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Development of acute myeloid leukemia in patients with untreated chronic lymphocytic leukemia

et al. 2017

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The development of acute myeloid leukemia (AML) in patients with untreated chronic lymphocytic leukemia (CLL) is rare. We experienced a 65-year-old man who developed AML with aberrant CD7 expression and monoallelic CEBPA mutation during watchful waiting for CLL. He failed to achieve complete response (CR) by standard induction therapy for AML. We retrospectively reviewed 27 patients who developed AML with untreated CLL published between 1973 and 2016. The median age at diagnosis of AML was 68 years, and the median duration between the diagnoses of AML and CLL was 4.2 years. Diagnosis of AML and CLL was made simultaneously in 16 patients. The CR rate of AML was 42.9%, and the median survival was only 1.5 months after the diagnosis of AML. Patients who achieved CR tended to survive longer than those who did not. Our results demonstrated that the development of AML in patients with untreated CLL was associated with a poor response to chemotherapy and an extremely poor prognosis.

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Cytogenetic and immunophenotypic evidence of independent clonal origins of concomitant chronic lymphocytic leukaemia and acute myeloid leukaemia

Cited by 12 publications

References 10 publications

Features of cytogenetic diagnosis of simultaneous chronic lymphocytic leukemia and myelodysplastic syndrome: clinical case report

Features of cytogenetic diagnosis of simultaneous chronic lymphocytic leukemia and myelodysplastic syndrome: clinical case report

Coexistence of follicular lymphoma and an unclassifiable myeloproliferative neoplasm in a treatment-naïve patient: A case report

Development of acute myeloid leukemia in patients with untreated chronic lymphocytic leukemia

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