Cytogenetic and morphologic subgroups of myelodysplastic syndromes in relation to occupational and hobby exposures

Albin, María; Björk, Jonas; Welinder, Hans; Tinnerberg, Håkan; Mauritzson, Nils; Billström, Rolf; Strömberg, Ulf; Mikoczy, Zoli; Johansson, Bertil; Ahlgren, Tomas; Nilsson, Per‐Gunnar; Mitelman, Felix; Hagmar, Lars

doi:10.5271/sjweh.744

Cited by 10 publications

(3 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Environmental exposures have been shown to be more strongly associated with MDS characterized by abnormal cytogenetics[35-38], a phenomenon observed in the current study population (data not shown), thus, it is possible that these exposures may contribute to MDS etiology through induction of chromosomal abnormalities, telomere attrition, or both.…”

Section: Discussionmentioning

confidence: 70%

Telomere length in myelodysplastic syndromes

Rollison¹,

Epling-Burnette²,

Park³

et al. 2011

Leukemia & Lymphoma

View full text Add to dashboard Cite

The relationship between telomere length (TL) and predisposition to myelodysplastic syndromes (MDS) remains unclear. We compared peripheral blood leukocyte (PBL) TL among cases of histologically-confirmed MDS (n=65) who were treatment-naive with no prior cancer history to age-matched controls (n=63). Relative TL was measured in PBL and saliva by quantitative PCR and in CD15+ and CD19+ cells by Flow-FISH. Human telomerase reverse transcriptase gene (hTERT) mutations were assessed by PCR. After adjustment for age and sex, relative TLs were reduced in PBL (p=0.02), CD15+ (p=0.01), CD19+ (p=0.25) and saliva (p=0.13) in MDS cases versus controls, although only PBL and CD15+ results were statistically significant. Among MDS cases, CD15+ and CD19+ cell TLs positively correlated (p=0.03). PBL TL was reduced among those occupationally exposed to paints and pesticides, but was not associated with hTERT genotype. Future studies are needed to further investigate constitutional telomere attrition as a possible predisposing factor for MDS.

show abstract

Section: Discussionmentioning

confidence: 70%

Telomere length in myelodysplastic syndromes

Rollison¹,

Epling-Burnette²,

Park³

et al. 2011

Leukemia & Lymphoma

View full text Add to dashboard Cite

show abstract

“…34 Our findings that smokers who were also exposed to chemicals had the highest risk of MDS as compared to nonsmokers without chemical exposure suggest an interaction between these two factors that needs to be considered when determining overall risk.…”

Section: Discussionmentioning

confidence: 72%

“…10,18 Our data support the association between being exposed to pesticides, herbicides, or fertilizers and risk of MDS found in some [31][32][33] but not all previous studies. 8,34 This association was found among men but not women, possibly due to the limited number of women who reported exposure to agrochemicals. In contrast, Ciccone et al 18 Table 5 Characteristics by FAB type among cases reported a statistically significant association with exposure to pesticides only among women.…”

Section: Discussionmentioning

confidence: 92%