Cytogenetic biomonitoring in oral mucosa cells following dental X-ray

Ribeiro, Daniel Araki

doi:10.1259/dmfr/14555883

Cited by 25 publications

(17 citation statements)

References 30 publications

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“…3 Theoretically, the biological effects of dental panoramic exposure can damage cells through oxidative reaction, including the formation of micronucleus. 4,5 A micronucleus is often employed as a biomarker of chromosomal damage that, in its early stages, contributes to carcinogenesis. 6 Research has confirmed the increase in micronucleus after conventional panoramic radiograph exposure which has a correlation with 8-oxo-dG expression as a marker of DNA adduct.…”

Section: Research Report Introductionmentioning

confidence: 99%

Biological changes after dental panoramic exposure: conventional versus digital

Shantiningsih

Diba

2018

Dent. J.

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Background: Dental digital radiography is more practical and requires fewer doses of radiation than conventional radiography. Because ionizing radiation has a biological effect on exposed tissue, concerns regarding its stochastic effect merit greater attention. In a previous study, it was found that biological changes and increases in the micronucleus occurred after conventional panoramic exposure to gingival crevicular fluid (GCF). Purpose: The purpose of this study is to investigate the difference in biological effects

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Section: Research Report Introductionmentioning

confidence: 99%

Biological changes after dental panoramic exposure: conventional versus digital

Shantiningsih

Diba

2018

Dent. J.

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“…Nowadays the lesions detection and disease diagnosis are based on clinical and paraclinic findings. In the past decades, x-rays have been used widely in dentistry (1). Dental radiology is being extensively used especially after the consolidation of the dental implant technique (2).Therefore radiographic findings play an important role.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Radiation Exposure of Head and Neck during Panoramic Radiography in Different Age Groups

Moudi¹

2014

SJCM

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Background and aim: Panoramic imaging is one of the most commonly used imaging techniques in dentistry.Being able to accurately assess the radiation dose patients receive during procedures is a crucial step in the management of dose. The main objective of this study was to evaluate the head and neck skin absorbed dose during panoramic radiography in different age groups with panoramic machine of Oral and Maxillofacial Radiology section of Babol school of dentistry. Materials and methods: 273 thermoluminescent dosemeters (TLDs) (100 LiF: Mg, Ti , harshaw, USA) were used.90 samples were selected from the patients who referred to the Oral and Maxillofacial Radiology section of Babol school of dentistry for panoramic radiography. .Samples divided in 3 age_ group: 4_ 10 years, 10_40 years and above 40 years . TLDs were calibrated in dosimetry laboratory, National Radiation Protection Department. Thermoluminescent signal was read out with a Harshaw 4500 (Harshaw, Bicron USA) reader. Mean and standard deviation was determined by SPSS10 software and ANOVA statistic analysis. Results: Mean ± SD of skin absorbed dose of head and neck for 90 patients was 0.47± 0.09mGy. Conclusions: Since Diagnostic Reference level (DRL) of panoramic imaging is unknown in Iran, there is no possibility to compare the current results with DRL. However, This study conclude that decrease of radiation dose seems to be achievable with lower exposure condition with the panoramic unit.

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“…These studies, however, all reported increases in other nuclear alterations (e.g. pyknosis, karyorrhexis and karyolysis) that are associated with increased cytotoxicity [63][64][65][66] . Recently, Preethi et al (2016) reported significant increases in the number of micronucleated cells in BMCs after dental radiography in paediatric patients 62 .…”

Section: Discussionmentioning

confidence: 95%

Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan

Belmans

Gilles

Vermeesen

et al. 2020

Sci Rep

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Assessing the possible biological effects of exposure to low doses of ionizing radiation (IR) is one of the prime challenges in radiation protection, especially in medical imaging. Today, radiobiological data on cone beam CT (CBCT) related biological effects are scarce. In children and adults, the induction of DNA double strand breaks (DSBs) in buccal mucosa cells and 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxo-dG) and antioxidant capacity in saliva samples after CBCT examination were examined. No DNA DSBs induction was observed in children nor adults. In children only, an increase in 8-oxo-dG levels was observed 30 minutes after CBCT. At the same time an increase in antioxidant capacity was observed in children, whereas a decrease was observed in adults. Our data indicate that children and adults react differently to IR doses associated with CBCT. Fully understanding these differences could lead to an optimal use of CBCT in different age categories as well as improved radiation protection guidelines. Uncertainties concerning low dose ionizing radiation exposure and medical imaging. Currently, a debate exists within the radiation protection community about which model best reflects the relation between the ionizing radiation (IR) dose and the additional health risk. Several models have been described thus far. These include: the linear non-threshold (LNT) model, the linear threshold model, the hormetic model and the hypersensitivity model 1. Currently, the linear non-threshold (LNT) model is used to estimate risks in radiation protection guidelines. Although the LNT model is supported by epidemiological evidence in the high dose range (>100 milliGray (mGy)), increasing evidence disproves it in the low dose range 2-5. One of the main critiques is the fact that the LNT model does not take into account biological defence mechanisms (e.g. DNA repair mechanisms) 6,7. In addition, a lot of uncertainties still exist about low doses (<100 mGy), mostly because of a lack of statistical power of the epidemiological data. Knowing which of these models supports the relation between exposure to low doses of IR and the involved risk best is of importance in medical imaging applications of IR. Such applications include computed tomography (CT) and, more recently, cone beam computed tomography (CBCT), which typically uses doses far below 100 mGy, (typically between 0.01-0.10 mGy) 8-11. Multiple controversial studies indicate that exposure of children to diagnostic radiology may lead to radiation-induced malignancies later in life. Retrospective studies observed that the use of CT scans in children could triple the risk of leukaemia and brain cancers 12-14. A 24% increase in cancer incidence was seen in an

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Cytogenetic biomonitoring in oral mucosa cells following dental X-ray

Cited by 25 publications

References 30 publications

Biological changes after dental panoramic exposure: conventional versus digital

Biological changes after dental panoramic exposure: conventional versus digital

Assessment of Radiation Exposure of Head and Neck during Panoramic Radiography in Different Age Groups

Quantification of DNA Double Strand Breaks and Oxidation Response in Children and Adults Undergoing Dental CBCT Scan

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