Cytogenetic Clonal Evolution in Patients with Chronic Myeloid Leukemia

Recurrent Monosomies Confirmed by Interphase FISH in Three Chronic Myeloid Leukemia Cases

“…We have published our results on clonal chromosome abnormalities other than the Ph chromosome in Ph+ and Ph- cells of CML patients who were followed in our center a few years ago [ 2 , 3 ]. Monosomies were the most frequently observed chromosome abnormalities in these reports.…”

Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib

“…As previously described, patients were diagnosed with CML-AP based on the standard definition (i.e., hematologic criteria 4 or clonal evolution); patients with progression of a prior CML-AP diagnosis after achieving a hematologic response were also eligible 4 . Clonal evolution included additional chromosomal abnormalities besides the Ph chromosome (e.g., +8, +19, iso17q) 8 . After 2 years, patients who experienced-specific AEs (e.g., any-grade recurring fluid retention, including pleural and/or pericardial effusion, or any-grade gastrointestinal bleed despite dose reduction by one level) were allowed to switch from BID to QD dosing, but data were analyzed based on the initial randomization arm.…”