Cytogenetic damage in bidi smokers

Yadav, J. S.; Thakur, Sachin

doi:10.1080/14622200050011367

Cited by 22 publications

(6 citation statements)

References 40 publications

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“…[11–13] Increases in the frequencies SAs have been reported with exposure to cigarette smoke,[910] bidi smoke,[14] and hookah smoke. [15] The present report confirms these findings.…”

Section: Discussionsupporting

confidence: 91%

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Smoking-induced satellite associations in a rural population of south India: An in vitro study

Uma

Ranganadin

Raj

et al. 2011

Int J App Basic Med Res

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Background:Genotoxic carcinogens in cigarette smoke interact with DNA, causing cytotoxicity. Cytogenetic damage therefore seems to be an excellent biomarker for determining the effect of exposure to chromosome-damaging agents in cigarette smoke.Purpose:To study the utility of measurement of frequency of satellite associations (SA) as a biomarker for chromosomal damage using cytogenetic assay in peripheral blood lymphocytes.Materials and Methods:This study was conducted on 30 smokers and 30 nonsmokers drawn from a rural population of South India. Smokers were divided into three groups of ten each based on their smoking index (SI) (group I: SI < 150, group II: SI 150–300, and group III: SI > 300) and the frequency of SAs was studied.Results:The frequency of SAs was significantly greater in smokers than in nonsmokers and the frequency of SAs among the smokers was also seen to increase with increase in SI.Conclusion:The results of this study indicate that the genotoxic effect of cigarette smoke on chromosomes increases with smoking intensity. These findings can be used to support smoking cessation interventions.

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“…[11–13] Increases in the frequencies SAs have been reported with exposure to cigarette smoke,[910] bidi smoke,[14] and hookah smoke. [15] The present report confirms these findings.…”

Section: Discussionsupporting

confidence: 91%

“…[11–13] Chromosomal damage has also been reported in bidi and hookah smokers. [1415] The addition of antioxidants to the diet of the smokers was found to minimize the genotoxicity of the mutagenic agents present in tobacco smoke. [16]…”

Section: Introductionmentioning

confidence: 99%

Smoking-induced satellite associations in a rural population of south India: An in vitro study

Uma

Ranganadin

Raj

et al. 2011

Int J App Basic Med Res

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“…Perhaps most alarming is the national survey data that reveal that adolescent smokers are more likely to report ATP use than nonsmokers (Bombard, Rock, Pederson, & Asman, 2008). Not only do ATPs pose significant health risks when used alone (Baker et al, 2000; Raad et al, 2011; Yadav & Thakur, 2000), the combined use of cigarettes and ATPs may exacerbate further the risk of morbidity and mortality (Chao et al, 2002; Ferrence & Stephens, 2000). …”

Section: Introductionmentioning

confidence: 99%

Trends in alternative tobacco use among light, moderate, and heavy smokers in adolescence, 1999–2009

Nasim¹,

Khader²,

Blank³

et al. 2012

Addictive Behaviors

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Objective To examine trends in alternative tobacco product (ATP) use (smokeless tobacco, cigars, and bidis/cloves) among a national sample of adolescent cigarette smokers (light, moderate, and heavy) during 1999–2009. Method A secondary analysis of data from the 1999–2009 National Youth Tobacco Survey was performed to investigate the tobacco behaviors of 6th through 12th graders enrolled in public and private schools in the United States. Long-term trends in ATP use were analyzed using logistic regression – controlling for sex, grade, and race/ethnicity – and simultaneously assessing linear and higher order time effects and their interaction with cigarette smoking status. Results During 1999–2009, increases in smokeless tobacco use and decreases in bidis/cloves use were observed across all smoking groups. For cigars, declines were observed for heavy and moderate smokers, but levels returned to baseline levels in 2009. Cigar use among light smokers was less variable. Rates of any ATP were highest among heavy smokers and lowest among light smokers. Conclusion Trends in cigarette and SLT use increased dramatically in the past decade, and this increase is evident across all cigarette smoker types. Implications for tobacco surveillance, prevention and cessation programs, and tobacco control policies are discussed.

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“…Similar findings were also reported by Mahimkar and Bhisey[2] who found a significant increase in CA in bidi tobacco processors due to occupational exposure. Yadav and Thakur[13] worked on the genotoxic effects of bidi smoking and found a significant increase in the CA% as compared to that in the nonsmokers. Increase in CA% of smokers was also found by a Nordic study group.…”

Section: Discussionmentioning

confidence: 99%

Tobacco Dust induced genotoxicity as an occupational hazard in workers of bidi making cottage industry of central India

Khanna¹,

Gautam²,

Gokhale³

et al. 2014

Toxicol Int

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Context:To explore genotoxicity in bidi rollers occupationally exposed to bidi tobacco dust.Aims:To assess the extent of genotoxicity of tobacco dust to bidi rollers of Jabalpur, Madhya Pradesh, India and cytotoxicity of bidi tobacco extract.Settings and Design:Blood samples from 31 bidi rollers and 30 controls taken after written informed consent were analyzed for chromosome aberrations (CA) and comet assay.Materials and Methods:Genotoxicity was studied by CA in cultured peripheral blood lymphocytes of bidi rollers and the deoxyribonucleic acid (DNA) damage studies were done by comet assay of their blood. The toxicity of bidi tobacco extract to normal human lymphocytes was studied by MMT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay as drop in viability.Statistical Analysis Used:Student's t-test and DMRT.Results:There is a general trend of increase in CA% of both in exposed and control groups with age, but in every group the bidi rollers have a significantly higher CA% than the controls. The CA % is also directly related to exposure. The comet assay findings reveal that the mean comet length and tail length increases with exposure time. The toxicity of bidi tobacco extract (TE) to normal human lymphocytes was tested in vitro by 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay at 2 h of incubation. The trend of drop in viability with increasing concentrations of TE was clearly evident from the data from four donors in spite of their individual differences in viability.Conclusions:The results obtained in this investigation indicate that bidi rollers seem to be facing the occupational hazard of genotoxicity due to handling bidi tobacco and inhalation of tobacco dust. They should be advised to work under well-ventilated conditions.

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Cytogenetic damage in bidi smokers

Cited by 22 publications

References 40 publications

Smoking-induced satellite associations in a rural population of south India: An in vitro study

Smoking-induced satellite associations in a rural population of south India: An in vitro study

Trends in alternative tobacco use among light, moderate, and heavy smokers in adolescence, 1999–2009

Tobacco Dust induced genotoxicity as an occupational hazard in workers of bidi making cottage industry of central India

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