Cytogenetic Effect of the Chloroacetanilide Herbicide Alachlor in Somatic and Germ Cells of the Mouse

Abstract

SummaryThe cytogenetic effect of the herbicide alachlor was determined in cultured mouse spleen cells in vitro and in mouse somatic and germ cells in vivo. A dose dependent increase of chromosomal aberrations was observed in cultured mouse spleen cells after treatment with the concentrations 10 Ϫ7-10 Ϫ4 M alachlor/ml medium. The results of the present study reveal the genotoxicity of alachlor in the different mouse cells analyzed. This has to be taken in consideration when using this herbicide in agriculture.

Improving pollutants environmental risk assessment using a multi model toxicity determination with in vitro, bacterial, animal and plant model systems: The case of the herbicide alachlor

“…Among the risks of human exposure, diminished sperm quality (affecting sperm concentration and morphology (Grizard et al, 2007)), and the increased incidence of cancer, such as colorectal cancer and leukemia (Lee, 2004) or laryngeal cancer and myeloid leukemia (Lerro et al, 2018). In animals models, namely Wistar rats, alachlor induced nasal (Burman et al, 2003), thyroid and stomach cancers (Acquavella et al, 2004), as well as chromosomal aberrations in bone marrow (Amer et al, 2007). Alachlor is an in vitro clastogen (mutagen agent) in human blood lymphocytes (Ladeira and Smajdova, 2017) and in Chinese hamster ovary cells (Lin et al, 1987).…”