Cytogenetic effects induced by organophosphorus pesticides in mouse spermatocytes

Degraeve, N.; Chollet, Marie-Christine; Moutschen, J.

doi:10.1016/0378-4274(84)90090-0

Cited by 15 publications

(3 citation statements)

References 5 publications

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“…An in vitro cell transformation test was negative (OECD, 2002). Injection of 300 mg/kg TEP in male mice did not evoke chromosomal damage in sperm (Degraeve, Chollet, & Moutschen, 1984).…”

Section: Resultsmentioning

confidence: 91%

Solvent‐based paint and varnish removers: a focused toxicologic review of existing and alternative constituents

Durrani

Clapp

Harrison

et al. 2020

J of Applied Toxicology

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Paint and varnish removers constitute a major potential source of organic solvent exposure to contractors and home improvement enthusiasts. Unfortunately, the leading paint remover formulations have traditionally contained, as major ingredients, chemicals classified as probable human carcinogens (eg, methylene chloride) or reproductive toxicants (eg, N‐methylpyrrolidone). In addition, because of its unique toxicology (ie, hepatic conversion to carbon monoxide compounding generic solvent narcosis and arrythmogenesis), high volatility, and rigorous requirements for personal protective equipment, methylene chloride exposures from paint removers have been linked to numerous deaths involving both occupational and consumer usage. The aim of this review is to summarize the known toxicology of solvent‐based paint remover constituents (including those found in substitute formulations) in order to provide health risk information to regulators, chemical formulators, and end‐users of this class of products, and to highlight any data gaps that may exist.

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“…An in vitro cell transformation test was negative (OECD, 2002). Injection of 300 mg/kg TEP in male mice did not evoke chromosomal damage in sperm (Degraeve, Chollet, & Moutschen, 1984).…”

Section: Resultsmentioning

confidence: 91%

Solvent‐based paint and varnish removers: a focused toxicologic review of existing and alternative constituents

Durrani

Clapp

Harrison

et al. 2020

J of Applied Toxicology

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“…Malathion or its metabolite malaoxon was not mutagenic in several Salmonella strains (11)(12)(13), nor did it induce sex-linked recessive lethal mutations in Drosophila melanogaster (14). The findings of both in vitro and in vivo studies of cytogenetic changes in humans and other mammals have been inconsistent (15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33). In contrast, the US Environmental Protection Agency concluded in 2000 that there was ''suggestive evidence of carcinogenicity but not sufficient to assess human carcinogenic potential'' (34).…”

mentioning

confidence: 99%

Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study

Bonner

Coble

Blair

et al. 2007

American Journal of Epidemiology

122

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Malathion is the most common organophosphate insecticide applied in the United States, and while some studies suggest that it may be clastogenic, its carcinogenicity has not been demonstrated in rodents. However, malathion has been associated with non-Hodgkin's lymphoma in several epidemiologic studies. The authors investigated associations between malathion exposure and cancer among 19,717 pesticide applicators enrolled in the Agricultural Health Study between 1993 and 1997. Information on lifetime years and days per year of use and intensity of malathion exposure was obtained with self-administered questionnaires prior to the onset of any cancer. The average follow-up time was 7.5 years (1993-2002). Rate ratios and 95% confidence intervals were calculated using Poisson regression, adjusting for potential confounders. Overall, lifetime days of malathion use (top tertile of exposure, >39 days) was not associated with all cancers combined (rate ratio = 0.97, 95% confidence interval: 0.81, 1.15). The risk of non-Hodgkin's lymphoma was not associated with malathion use, although the number of cases was small. The risk of melanoma with more than 39 lifetime exposure-days was 0.39 (95% confidence interval: 0.14, 1.03). In summary, malathion exposure was not clearly associated with cancer at any of the sites examined. Although the rate ratios for melanoma were reduced, small numbers and lack of experimental evidence suggest that the observed reductions may have arisen by chance.

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“…In parallel with the decreased 7Sd count and increased percentage of 7Sd degeneration, a marked reduction was also observed in the sperm count. Earlier reports have revealed degenerative changes in the testicular histology of the experimental animals following treatment with organochlorine (Barlow & Sullivan, 1982;Working, Bus & Hamm, 1985) and organophosphorus (Saxena & Sarin, 1980;Degraeve, Chollet & Moutschen, 1984) compounds. It has been reported that LH, via testosterone production, and FSH are required to obtain quantitat¬ ively normal spermatogenesis in pubertal rats (Russell, Alger & Nequin, 1987).…”

Section: Discussionmentioning

confidence: 95%

Effect of aldrin on spermatogenesis, plasma gonadotrophins and testosterone, and testicular testosterone in the rat

Chatterjee

Ray²,

Ghosh³

et al. 1988

Journal of Endocrinology

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Quantitative evaluation of the different varieties of germ cells at stage VII of the seminiferous epithelium cycle, namely type-A spermatogonia (ASg), preleptotene spermatocytes (pLSc), mid-pachytene spermatocytes (mPSc) and step 7 spermatids (7Sd), along with radioimmunoassay of plasma gonadotrophins (FSH and LH), testosterone and testicular testosterone were performed in Wistar rats following treatment with aldrin (polycyclic chlorinated hydrocarbon insecticide) for approximately one (13 days) or two cycles (26 days) of the seminiferous epithelium. Extensive degeneration of all varieties of germ cells at stage VII, reduction in the sperm count and significant reductions in plasma concentrations of LH and testosterone were observed following aldrin treatment. The reduction in plasma concentrations of FSH was statistically significant only after treatment for two cycles. The inhibitory effect of aldrin on plasma gonadotrophins, testosterone levels, testicular testosterone content and numbers of 7Sd and ASg was maximum after treatment for two cycles. Administration of human chorionic gonadotrophin along with aldrin treatment for two cycles partially prevented the degeneration of germ cells and enhanced testosterone production. The results indicate that aldrin may have a direct inhibitory influence on gonadotrophin release, but the possibility of a direct action of the insecticide at the level of the testes is also discussed.

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Cytogenetic effects induced by organophosphorus pesticides in mouse spermatocytes

Cited by 15 publications

References 5 publications

Solvent‐based paint and varnish removers: a focused toxicologic review of existing and alternative constituents

Solvent‐based paint and varnish removers: a focused toxicologic review of existing and alternative constituents

Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study

Effect of aldrin on spermatogenesis, plasma gonadotrophins and testosterone, and testicular testosterone in the rat

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