Cytogenetic findings in chronic myeloid leukemia (CML); evaluation of karyotype, blast morphology, and survival in the acute phase

Bernstein, R; Morcom, G.; Pinto, M. R.; Mendelow, B.; Dukes, I. A. F.; Penfold, G.; Bezwoda, W. R.

doi:10.1016/0165-4608(80)90077-1

Cited by 49 publications

(14 citation statements)

References 28 publications

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“…Our data on the type and frequency of chromosome abnormalities in 106 cases of CML appeared to be somewhat different from those reported by the FIWCL (1978) and some other authors who studied relatively large numbers of CML cases (Lawler et al, 1976;Engel et al, 1977;Seabright and Pearson, 1978;Pasquali et al, 1979;Stoll and Oberling, 1979;Bernstein et al, 1980;Hagemeijer et al, 1980;Kohno and Sandberg, 1980;Sadamori et al, 1980;Fleischman et al, 1981;Potter et al, 1981 ;Oshimura et aI., 1982).…”

Section: Discussioncontrasting

confidence: 90%

“…Limiting the data on 20 cases which were studied in both CP and BP, the incidence was estimated to be 15~ (3/20) in CP, and 65~ (13/20) in BP. These values do not seem to be much deviating from those reported from other laboratories, where the incidence varied from less than 10~ (Bernstein et al, 1980) to 20-30~ in CP (Hayata et al, 1975;Lawler et al, 1976;Sonta and Sandberg, 1978;Kohno and Sandberg, 1980), and from 60~ (Pasquali et al, 1979) to more than 85~ in BP (Sonta and Sandberg, 1978;Stoll and Oberling, 1979;Bernstein et al, 1980).…”

Section: Discussionsupporting

confidence: 42%

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Chromosome banding studies in 106 cases of chronic myelogenous leukemia

et al. 1982

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SummaryChromosome banding studies performed on 106 cases of CML in Sapporo revealed that 101 (95.3~) were Phi-positive, and 5 (4.7~) Phi-negative, the latter including a case of juvenile type CML. Of the 101 Phi-positive patients, 98 showed the standard type Ph ~ translocation, t(9;22)(q34;qll), while the remaining 3 had a complex Ph 1 translocation as represented by t(4;9;22), t(9;14;22), or t(9;10;15;19;22). There were 28 patients who showed otl~ler chromosome changes in addition to the Ph ~ translocation. Trisomy 8, duplication of Ph ~, isochromosome 17q, and trisomy 19 were most frequently involved in the additional changes, and 2 or more of them often participated in the major routes of karyotypic evolution. Other additional changes observed were 6 translocations, 4 partial deletions, 2 partial trisomies for lq, trisomies 6, 7, 12, 15, and 21, a monosomy 5, a partial duplication of no. 9, a missing Y, and so on.The present cytogenetic findings were evaluated with respect to some of the clinical and therapeutic parameters.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussionsupporting

confidence: 42%

Chromosome banding studies in 106 cases of chronic myelogenous leukemia

et al. 1982

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“…Second, it has been debated whether additional changes found during chronic phase constitute a dismal prognostic sign, announcing transformation. On one hand, as has been repeatedly highlighted, the emergence of new clones does not necessarily lead to disease progression and some clones appear only transiently [23,42,43]. On the other hand, the appearance of new ACA or increment of the clone with additional abnormalities has been shown to be generally associated with clinical deterioration [28,37,44].…”

Section: Chronic Phasementioning

confidence: 91%

“…However, the prognostic impact of ACA has turned out to be difficult to assess. First, although most studies have reported that lack of ACA during blastic phase give rise to a better prognosis [32, 33, 37-41], some investigators have not found any prognostic differences between CML blastic phase cases with and without secondary changes [23,30]. Second, it has been debated whether additional changes found during chronic phase constitute a dismal prognostic sign, announcing transformation.…”

Section: Chronic Phasementioning

confidence: 99%

“…In 60-80% of the cases, ACA precede or accompany blastic phase [14,15,[23][24][25][26][27][28][29][30][31][32][33], thus there is undoubtedly a strong association between secondary changes and transformation. Furthermore, early studies of splenic CML transformations give rise to strong support for the clinical importance of additional changes, showing that the secondary aberrations appeared in the spleen before bone marrow [34][35][36].…”

Section: Chronic Phasementioning

confidence: 99%

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BCR/ABL1 Extra Fusions in Patients with Chronic Myeloid Leukaemia (CML)

Vargas¹

2011

Myeloid Leukemia - Basic Mechanisms of Leukemogenesis

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Sequential karyotype study on Ph-positive chronic myelocytic leukemia. Significance of additional chromosomal abnormalities during disease evolution

Krulik¹,

Smadja²,

Gramont³

et al. 1987

Cancer

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Twenty-eight patients with Ph-positive chronic myelocytic leukemia (CML), who all died of the disease, had cytogenetic studies throughout the progression of the disease: at diagnosis, during chronic phase (CP), accelerated phase (AP), and blastic transformation (BT). The aim of this sequential study was to appreciate the frequency and the significance of additional chromosomal abnormalities (ACA) during CML evolution, especially in the CP. In our series ACA were rare (five of 28 patients) and simple (four of five) in CP. They were much more frequent and complex in AP (11 of 16) and in BT (22 of 24) with complex abnormalities (13 of 24). In CP, ACA predictive value for metamorphosis was poor: only three of 13 patients had ACA within 1 year before BT, and only two of 11 within 1 year before AP. ACA were mainly observed during the last period before BT: ten of 17 patients studied within 6 months prior BT had ACA, but by then two of three were in AP. ACA, especially when complex, appear to be a hallmark of CML metamorphosis.

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Cytogenetic findings in chronic myeloid leukemia (CML); evaluation of karyotype, blast morphology, and survival in the acute phase

Cited by 49 publications

References 28 publications

Chromosome banding studies in 106 cases of chronic myelogenous leukemia

Chromosome banding studies in 106 cases of chronic myelogenous leukemia

BCR/ABL1 Extra Fusions in Patients with Chronic Myeloid Leukaemia (CML)

Sequential karyotype study on Ph-positive chronic myelocytic leukemia. Significance of additional chromosomal abnormalities during disease evolution

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