Cytogenetic findings in invasive breast carcinomas with prognostically favourable histology: A less complex karyotypic pattern?

Adeyinka, Adewale; Mertens, Fredrik; Idvall, Ingrid; Bondeson, Lennart; Ingvar, Christian; Heim, Sverre; Mitelman, Felix; Pandis, Nikos

doi:10.1002/(sici)1097-0215(19980821)79:4<361::aid-ijc9>3.0.co;2-t

Cited by 20 publications

(8 citation statements)

References 23 publications

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“…2,3,5,41 Cytogenetic data from a small number of cases demonstrates recurrent abnormalities including trisomy 18, der (1;16), del(3) (p13), and del(6)(q21), and in some cases a near triploid karyotype. 42 Medullary carcinomas both in the sporadic and familial setting tend to have p53 overexpression and BRCA1 mutation or inactivation. 2,3,5 Future studies may reveal immunohistochemical, gene expression profile, or molecular markers which are specific for medullary carcinoma, and can be applied to FNAC material.…”

Section: Resultsmentioning

confidence: 99%

Fine‐needle aspiration cytology of medullary breast carcinoma: Report of two cases and review of the literature with emphasis on differential diagnosis

Racz

Pommier

Troxell

2007

Diagnostic Cytopathology

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Medullary carcinoma is a rare variant of breast carcinoma with a relatively good clinical prognosis as strictly defined. Characteristic features on fine-needle aspiration cytology (FNAC) allow medullary carcinoma to be considered in the cytologic differential diagnosis. We present two FNAC cases with such features, including high cellularity with clusters and single intact malignant cells, bizarre stripped nuclei with prominent nucleoli in a lymphoplasmacytic background, and illustrate one case in liquid-based preparation. Surgical excision revealed that one patient had medullary carcinoma, while the second patient had high-grade infiltrating ductal carcinoma. Breast FNAC samples with syncytial fragments, bizarre nuclei with prominent nucleoli, and a chronic inflammatory infiltrate should raise the possibility of medullary carcinoma. However, the differential diagnosis also includes high-grade ductal carcinoma, lymphoma, or metastasis to breast or intramammary lymph nodes; thus, histopathologic analysis is required for definitive diagnosis.

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Section: Resultsmentioning

confidence: 99%

Fine‐needle aspiration cytology of medullary breast carcinoma: Report of two cases and review of the literature with emphasis on differential diagnosis

Racz

Pommier

Troxell

2007

Diagnostic Cytopathology

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“…changes Adeyinka et al, 1998). Medullary carcinomas, on the other hand, appeared to have karyotypes as complex as those found in the more common ductal carcinomas.…”

Section: Karyotypic-histopathologic Correlationsmentioning

confidence: 88%

Cytogenetic clues to breast carcinogenesis

Teixeira

Pandis

Heim

2001

Genes Chromosomes & Cancer

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The somatic mutation theory of cancer maintains that tumorigenesis is driven by genetic alterations, many of which are visible cytogenetically. We have examined breast cancer by chromosome banding analysis after short-term culturing of tumor cells and here review our findings in 322 karyotypically abnormal samples obtained since 1992 from 256 patients. The screening capabilities of this technique enabled us to identify several cytogenetic subgroups of breast cancer, to study the intratumor heterogeneity of breast carcinomas, and to compare primary tumors with their metastases. Using chromosome abnormalities as clonality markers, we could determine on an individual basis when multiple, ipsilateral or bilateral breast, tumors were independent de novo carcinomas and when they resulted from the spreading of a single malignant clone within one breast or from one breast to the other. The distribution of chromosomal breakpoints and genomic gains and losses is clearly nonrandom in breast cancer, something that can guide further investigations using molecular methods. Based on the total dataset, we propose a multipathway model of mammary carcinogenesis that takes into consideration the genetic heterogeneity revealed by the karyotypic findings and review the karyotypic-pathologic correlations and the possible clinical applications of the cytogenetic knowledge.

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“…Our study comprised 157 primary breast carcinomas with clonal chromosome aberrations, and for which information was available about axillary lymph node status. The 157 tumours included 41 unpublished and 116 previously published primary breast carcinoma cases (Adeyinka et al ., 1997, 1998, 1999; Pandis et al ., 1994, 1996, 1998) that were cytogenetically analysed at the Department of Clinical Genetics, University Hospital, Lund, Sweden.…”

Section: Methodsmentioning

confidence: 99%

Different patterns of chromosomal imbalances in metastasising and non-metastasising primary breast carcinomas

et al. 1999

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In an attempt to identify chromosomal abnormalities that may be associated with a metastatic phenotype, we investigated the pattern of chromosomal gains and losses in 66 node‐positive and 63 node‐negative primary breast carcinomas. For both subgroups of tumours, losses were more common than gains and the losses were most often the result of structural aberrations. The exceptions were the long arm of chromosome 1, and chromosomes 7, 8, 12, 18 and 20, which were more often gained than lost. Node‐negative tumours were preferentially characterised by loss of 6q10–21 and loss of 16q, whereas loss of chromosome 18 was significant for node‐positive tumours. Other aberrations that tended to be associated with one of the phenotypes, though not statistically significant, were gain of chromosome 18 and loss of chromosome 10 in node‐negative tumours, and gain of chromosome 14 and loss of 12p in node‐positive tumours. Our data show that there are differences among the genetic lesions present in node‐negative and node‐positive breast tumours. Int. J. Cancer (Pred. Oncol.) 84:370–375, 1999. © 1999 Wiley‐Liss, Inc.

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Cytogenetic findings in invasive breast carcinomas with prognostically favourable histology: A less complex karyotypic pattern?

Cited by 20 publications

References 23 publications

Fine‐needle aspiration cytology of medullary breast carcinoma: Report of two cases and review of the literature with emphasis on differential diagnosis

Fine‐needle aspiration cytology of medullary breast carcinoma: Report of two cases and review of the literature with emphasis on differential diagnosis

Cytogenetic clues to breast carcinogenesis

Different patterns of chromosomal imbalances in metastasising and non-metastasising primary breast carcinomas

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