Cytogenetic findings in pediatric radiation-induced atypical meningioma after treatment of medulloblastoma: case report and review of the literature

Brassesco, María Sol; Valera, Elvis Terci; Neder, Luciano; Pezuk, Julia Alejandra; Oliveira, Ricardo Santos de; Scrideli, Carlos Alberto; Tone, Luíz Gonzaga

doi:10.1007/s11060-012-0982-5

Cited by 13 publications

(5 citation statements)

References 27 publications

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“…1d–g , Supplementary Data 3 ). Previous reports of single cases or small series have implicated 1p in RIMs 20 – 23 , and a cytogenetic analysis of six cases has implicated 1p13 as a region involved in these tumors 21 . Overall, 16/18 cases showed dual loss of chromosomes 1p and 22q, suggesting that co-occurrence of 1p and 22q loss radiation-induced meningioma is a near-universal feature (89%, p < 0.05, Fisher’s exact test) of radiation-induced meningioma.…”

Section: Resultsmentioning

confidence: 93%

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

et al. 2017

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Cranial radiotherapy improves survival of the most common childhood cancers, including brain tumors and leukemia. Unfortunately, long-term survivors are faced with consequences of secondary neoplasia, including radiation-induced meningiomas (RIMs). We characterized 31 RIMs with exome/NF2 intronic sequencing, RNA sequencing and methylation profiling, and found NF2 gene rearrangements in 12/31 of RIMs, an observation previously unreported in sporadic meningioma (SM). Additionally, known recurrent mutations characteristic of SM, including AKT1, KLF4, TRAF7 and SMO, were not observed in RIMs. Combined losses of chromosomes 1p and 22q were common in RIMs (16/18 cases) and overall, chromosomal aberrations were more complex than that observed in SM. Patterns of DNA methylation profiling supported similar cell of origin between RIMs and SMs. The findings indicate that the mutational landscape of RIMs is distinct from SMs, and have significant therapeutic implications for survivors of childhood cranial radiation and the elucidation of the molecular pathogenesis of meningiomas.

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Section: Resultsmentioning

confidence: 93%

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

et al. 2017

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“…The two tumor types can occur simultaneously, or a glioma can appear after the treatment of a meningioma [ 5 , 8 - 10 ]. However, meningioma very rarely occurs concurrently with recurrent glioma following surgical excision of the original glioma from the lateral ventricle, and such coincidences are usually related to radiotherapy [ 11 - 13 ]. The meningioma in a collision tumor reported here not only occurred after the excision of an astrocytoma without radiotherapy but was also located in the middle of the astrocytoma.…”

Section: Introductionmentioning

confidence: 99%

An intraventricular meningioma and recurrent astrocytoma collision tumor: a case report and literature review

Zhang

Guo

et al. 2015

World J Surg Onc

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BackgroundIntracranial meningioma and glioma collision tumors are relatively uncommon and are even more rarely located within the ventricles.Case presentationHere, we report a case of a patient with an intraventricular meningioma and astrocytoma collision tumor. A 39-year-old man previously underwent excision of an astrocytoma in the triangle area of the lateral ventricle and exhibited good post-surgery recovery. The astrocytoma recurred in situ six years after the surgery, and the case was complicated by a malignant meningioma. The patient recovered well after surgery to treat the recurrence and was administered radiotherapy after discharge. In addition to reporting on this case, we conducted a literature review of collision tumors; based on this review, we propose several hypotheses regarding the formation of collision tumors.ConclusionsWe conclude that a possible cause of the collision tumor formation between the intracranial meningioma and the astrocytoma was the recurrence of an astrocytoma-induced malignancy of the arachnoid cells in the choroid plexus.

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“…Criteria of the radiation-induced tumors are well reported in the literature. To be considered a radiation-induced lesion, the tumor must fulfill the following criteria: 1) it must occur in the field of radiation; 2) tumor should be absent prior to irradiation as ensured in the first MRI performed at the initial diagnosis, prior to surgery and radiotherapy; 3) there must be a delay of several years from the time of treatment to its appearance (after high-dose radiotherapy for medulloblastoma, RIMs have been described after latency periods ranging from 5 to 27 years, with an average latency period of 17.8 years); 4) the induced lesion must differ histologically from the original tumor that was irradiated; and 5) the patient does not have a genetic disease (such as neurofibromatosis type II or others) or a condition predisposing to secondary malignancy (3) . In our case, all requirements were met.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Induced Benign Meningioma after Radiotherapy for Medulloblastoma: Case report and brief review of the literature

Gündüz

Abdallah²,

Emel

et al. 2018

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Medulloblastoma is one of the most common primary malignant brain tumors of central nervous system in children. The recommended treatment of this malignant neoplasm is aggressive surgery, followed by craniospinal radiotherapy (RTP) with/without chemotherapy. Radiation-induced meningioma is the most common brain neoplasm known to be caused by ionizing radiation. This report presents a patient who had undergonde an operation 25 years ago because of a cerebral mass lesion. The patient had experienced unsteady gait associated with nausea and vomiting 25 years ago. Cranial CT demonstrated a large, solid and contrast-enhanced midline vermian mass. Through midline suboccipital craniectomy mass was removed totally which was histopathologically diagnosed as desmoplastic medulloblastoma. The patient was given postoperative adjuvant RTP. The patient tolerated RTP well and she had been called for yearly controls for 25.5 years. The patient who had not any complaint at routine controls for 25.5 years had been brought to our hospital with headache, unsteady gait, nausea and vomiting. MRI demonstrated an isointense mass in the right cerebellopontine angle that consisted of two compartments; the medial compartment did not show contrast enhancement and the lateral compartment that was associated with dura showed moderate, and homogenous contrast enhancement The patient had been managed surgically using right suboccipital craniectomy followed by total resection of the lateral compartment and biopsy of the medial compartment was obtained which was thought to be radiation-induced fibrotic tissue. The mass was diagnosed histopathologically as fibroblastic meningioma WHO Grade I and the biopsy of medial compartment showed to be arachnoidal fibrosis. The patient was well and had no recurrence öat postoperative 30 months. Keywords: Radiation-induced meningioma, medulloblastoma in children, late effect of radiation therapy J Nervous Sys Surgery 2016;6(1-2):61-66 Posterior Fossa Medülloblastomun Tedavisinde Kullanılan Kraniyal Radyasyon Geç Komplikasyonu olan Serebellopontin Köşenin Menenjiomu: olgu Sunumu ve Literatür TaramasıMedülloblastom çocukluk çağında primer merkezi sinir sistem tümörlerinin en sık rastlanan malign beyin tümörlerinden biridir. Bu malign tümörün tedavisinde agresif cerrahi sonrasında kraniyospinal radyoterapi (RTP) ve/veya kemoterapi önerilmektedir. Radyasyonla ilişkili menenjiom, iyonize radyasyonun sonucu olarak en sık rastlanan beyin tümörüdür. Bu makalede, beyin kitlesi nedeniyle 25 yıl önce ameliyat geçiren hasta sunulmuştur. Yirmi beş yıl önce dengesiz yürüyüşle birlikte bulantı ve kusması vardı. Kraniyal BT'sinde büyük, sert, kontrast tutan orta hat vermiyan kitle izlenmiştir. Orta suboksipital kraniyektomi yapılarak histopatolojik olarak desmoplastik medülloblastom tanısı konulan kitle total olarak çıkartılmıştır. Hastaya ek olarak postoperatif RTP verildi. Hasta RTP'yi iyi tolere edilip 25,5 yıldır yıllık kontrollere çağırıldı. Bu rutin kontrollerde yakınması olmayan hasta 25,5 yılın sonunda baş ağrısı, den...

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Cytogenetic findings in pediatric radiation-induced atypical meningioma after treatment of medulloblastoma: case report and review of the literature

Cited by 13 publications

References 27 publications

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

Therapeutic radiation for childhood cancer drives structural aberrations of NF2 in meningiomas

An intraventricular meningioma and recurrent astrocytoma collision tumor: a case report and literature review

Radiation-Induced Benign Meningioma after Radiotherapy for Medulloblastoma: Case report and brief review of the literature

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